Abstract:
:Bufalin, which is one of prominent components of Chinese toad venom, was found to decrease the rate of cell proliferation of mouse melanoma clone B16-F10 cells and a concomitant stimulation of expression of its melanotic phenotype. The effect of bufalin on melanogenesis included stimulation of tyrosinase activity and increase of cellular melanin content. These effects became apparent after 48 hr exposure to 10(-4) M bufalin and increased thereafter. Other cardiotonic steroids, such as cinobufagin and ouabain, at the concentration of 10(-4) M for 6 days, also showed the stimulatory effect on melanin synthesis of B16-F10 cells, but not digitoxigenin.
journal_name
Life Scijournal_title
Life sciencesauthors
Zhang L,Yoshida T,Kuroiwa Ydoi
10.1016/0024-3205(92)90213-9subject
Has Abstractpub_date
1992-01-01 00:00:00pages
17-24issue
1eissn
0024-3205issn
1879-0631pii
0024-3205(92)90213-9journal_volume
51pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Angiotensin (AII) and atrial natriuretic peptide (ANP) exert opposite effects on phosphorylation of a 17.6 kDa nuclear protein from bovine adrenal glomerulosa cells. The protein was separated by sodium dodecyl sulfate electrophoresis and blotted onto polyvinylidene difluoride, and the N-terminal sequence was obtained....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90465-4
更新日期:1990-01-01 00:00:00
abstract::The concentrations of the trace amines, m-tyramine, p-tyramine, phenylethylamine and tryptamine, were measured in the striatum of the brain and in the kidney of adult rats treated with alpha-monofluoromethyldopa (MFMD), an inhibitor of aromatic amino acid decarboxylase. While MFMD decreased the levels of all four amin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90371-7
更新日期:1987-02-09 00:00:00
abstract::The mouse neuroblastoma x rat glioma hybrid NG108-15 was previously shown to express delta opioid receptors. Because neuroblastoma cells display different phenotypes and cloned cell lines are heterogenous, we studied the characteristics and distribution of human 125I-beta-endorphin (125I-beta E) binding sites in cultu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90306-a
更新日期:1992-01-01 00:00:00
abstract::The ability of selective mu- ([D-Ala2, NHPhe4, Gly-ol]enkephalin: DAMGO), delta1- ([D-Pen2, Pen5]enkephalin: DPDPE) and delta2- ([D-Ala2]deltorphin II: DELT II) opioid receptor agonists to activate G-proteins in the midbrain and forebrain of mice and rats was examined by monitoring the binding of guanosine-5'-O-(3-[35...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00422-1
更新日期:1999-01-01 00:00:00
abstract::The present study examines the signal transduction mechanism that is involved in the growth of vascular smooth muscle cells exposed to 4-hydroxynonenal (HNE) in vitro. This aldehyde component of oxidized low-density lipoprotein has been identified in atherosclerotic lesion. Exposure to HNE caused ERK, JNK, and p38 MAP...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01166-3
更新日期:2001-06-29 00:00:00
abstract::Food allergies have become increasingly prevalent during the past few decades. Diarrhea is one of the most frequent intestinal symptoms caused by food allergens and is characterized by imbalanced ion exchange and water transfer; however, the underlying mechanism of allergic diarrhea remains unclear. Water transfer acr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.04.036
更新日期:2007-06-20 00:00:00
abstract:AIMS:C-reactive protein (CRP) is an inflammatory cytokine that has been shown to be an independent predictor of future atherothrombotic events. Hyperactivity of endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by the endothelium, is linked with cardiovascular disease development and progression. ET-1 is s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.12.030
更新日期:2016-08-15 00:00:00
abstract::While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte ass...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90677-5
更新日期:1984-05-07 00:00:00
abstract::miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.117865
更新日期:2020-09-01 00:00:00
abstract::In order to examine possible selectivity of amine uptake by synaptic vesicles, the ATP-stimulated accumulation of 3H-5-hydroxytryptamine (5HT) by synaptic vesicles from rat whole brain was examined in a medium comprised largely of membrane-impermeant anions (d-tartrate). Such media have previously been shown to stabil...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90174-8
更新日期:1986-03-31 00:00:00
abstract::Resting pituitary levels of beta-endorphin-(beta-EP-IR), ACTH-(ACTH-IR), and alpha-MSH-(alpha-MSH-IR)-like immunoreactive material were found to differ among 16 inbred mouse strains. Hormone levels correlated genetically with severity of withdrawal from ethanol, which also differed among the strains. Ethanol dependenc...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90672-0
更新日期:1983-11-07 00:00:00
abstract:AIMS:Hyperhomocysteinemia (Hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. Epigenetic mechanisms play an important role in the pathogenesis of atherosclerosis induced by Hhcy. However, the exact mechanism is still undefined. Lesional apoptotic cells and necrotic core forma...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.02.003
更新日期:2017-03-15 00:00:00
abstract::Momordin II, a ribosome-inactivating protein from Momordica charantia seeds, was purified by a procedure involving a series of chromatographies on S-Sepharose, Sephadex G-50, CM-Sepharose, and Red Sepharose columns. Highly purified momordin II inhibited cell-free protein synthesis, released adenine from rat liver ribo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00389-6
更新日期:1999-01-01 00:00:00
abstract::The validity of a photoelectric method for continuous cerebral blood volume (CBV) measurement was tested and modified for the rat's brain. A new way of introducing a miniature light source between the two hemispheres and fixing a light sensitive silicone blue cell to the outer surface of the parietal bone was develope...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90163-3
更新日期:1986-11-03 00:00:00
abstract::Resveratrol, a polyphenolic substance found in grape skin, is proposed to account in part for the protective effect of red wine in the cardiovascular system. The aim of the present study is to investigate the action and possible mechanisms of resveratrol-produced regulation of plasma glucose in normal and diabetic rat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.02.002
更新日期:2007-04-10 00:00:00
abstract::Mitochondria are known to develop a series of abnormalities as a result of ischemia. The inability of mitochondria to resume normal function following reperfusion has been implicated as an important factor in irreversible cell damage. However, the mechanism of mitochondrial injury after ischemic brain insult is poorly...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90627-7
更新日期:1985-07-08 00:00:00
abstract::Gastric mucosal lipid peroxide levels, based on the amounts of thiobarbituric acid reacting substances, increased soon after oral application of absolute ethanol. On the other hand, gastric mucosal nonprotein sulfhydryl levels slightly but significantly decreased. Administration of 20% ethanol, a mild irritant which c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90216-x
更新日期:1986-06-09 00:00:00
abstract::Animal studies suggest nicotine and cannabinoids may significantly enhance the therapeutic value of neuroleptics in motor disorders. This was recently demonstrated in humans by the finding that chewing nicotine gum produced striking relief from tics and other symptoms of Tourette syndrome not controlled by neuroleptic...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(89)90444-x
更新日期:1989-01-01 00:00:00
abstract::The effects of aging on contractile response to angiotensin II and tachyphylaxis to it were investigated using aortic strips from rats aged 1.5, 4 and 22 months. Whether the endothelium was present or not, the contractile response to angiotensin II was greater and tachyphylaxis to it was less in 1.5-month-old rats tha...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90549-7
更新日期:1990-01-01 00:00:00
abstract::In fish liver catecholamines bind to beta-adrenoceptors (AR) and increase glucose release via cAMP augmentation. Alpha1-AR have recently been shown to mediate IP3 and Ca2+ elevation in catfish and eel hepatocytes, although their coupling to a physiological response has remained doubtful. We have perifused isolated cat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00216-7
更新日期:1999-01-01 00:00:00
abstract::Peptide nucleic acids (PNAs) are uncharged DNA analogs that hybridize to complementary sequences with high affinity and stability. We previously showed that PNAs, after intraperitoneal injection into rats, are effective antisense compounds in vivo. The present study was designed to test whether PNAs also have antigene...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01647-8
更新日期:2002-06-07 00:00:00
abstract::Dopamine inhibited basal, TRH-, IBMX- and A23187-stimulated prolactin secretion from rat anterior pituitary cells. However, dopamine did not inhibit prolactin secretion stimulated by elevated K+ concentrations. These data are interpreted in terms of dopaminergic inhibition of both cyclic AMP production and Ca2+ influx...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90338-2
更新日期:1984-08-13 00:00:00
abstract:AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.12.014
更新日期:2011-02-14 00:00:00
abstract:AIMS:Studies indicate that the pattern of shear stress determines the direction of endothelial progenitor cells (EPCs) differentiation. However, the mechanism remains largely unknown. Herein, we try to identify the role of oscillatory shear stress (OSS) in the transdifferentiation of EPCs into mesenchymal cells and the...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117728
更新日期:2020-07-15 00:00:00
abstract:AIMS:Acetylcholine is synthesized in more or less all mammalian cells. However, little is known about the subcellular location of acetylcholine synthesis. Therefore, in the present experiments the subcellular location of the synthesizing enzyme choline acetyltransferase (ChAT) was investigated by anti-ChAT immunogold e...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.05.012
更新日期:2012-11-27 00:00:00
abstract::Phencyclidine hydrochloride (PCP) was tested for its ability to alter a variety of immune effector and regulatory functions in vitro. B6C3F1 murine splenic lymphocytes or elicited peritoneal macrophages were cultured in vitro with medium only or medium containing 10(-10)-10(-4) M PCP. Macrophages cultured with or with...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90584-p
更新日期:1993-01-01 00:00:00
abstract::To investigate whether endogenous opioid peptides mediate time-dependent changes in ventilatory control during prolonged hypoxia, we studied four adult goats at rest during 14 days at simulated high altitude in a hypobaric chamber (PB approximately 450 Torr). Arterial PCO2 fell during the first several hours of hypoxi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90260-8
更新日期:1987-02-16 00:00:00
abstract:AIMS:Obesity is a complex health disorder and a trigger to many diseases like Diabetes mellitus (DM) and breast cancer (BrCa), both leading causes of morbidity and mortality worldwide. Also evidence demonstrates that abnormal glucose metabolism termed 'the Warburg effect' in cancer cell is closely associated with malig...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.03.016
更新日期:2019-04-15 00:00:00
abstract::Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Japan and Taiwan. Studies have shown the hypoglycemic effects of Chlorella in alloxan-induced and Streptozocin (STZ)-induced diabetic animals. However, the mechanisms by which Chlorella treatment affects blood glucose homeostasis have ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.06.050
更新日期:2006-02-09 00:00:00
abstract:AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117555
更新日期:2020-08-01 00:00:00