Abstract:
AIMS:C-reactive protein (CRP) is an inflammatory cytokine that has been shown to be an independent predictor of future atherothrombotic events. Hyperactivity of endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by the endothelium, is linked with cardiovascular disease development and progression. ET-1 is sensitive to inflammatory stimuli, though the influence of CRP on ET-1 system activity is unknown. We tested the hypothesis that ET-1-mediated vasoconstrictor tone is enhanced in adults with elevated plasma CRP concentrations. MATERIALS AND METHODS:Sixty non-obese adults (43-70years) were studied: 20 with hsCRP<1.0mg/L (low CRP; 0.5±0.1mg/L); 20 with hsCRP 1.0-3.0mg/L (moderate CRP; 2.0±0.1mg/L); and 20 with hsCRP>3.0mg/L (high CRP; 6.3±0.5mg/L). Forearm blood flow (FBF; plethysmography) was determined in response to intra-arterial infusions of ET-1 (5pmol/min for 20min) and selective ETA receptor blockade (BQ-123, 100nmol/min for 60min). KEY FINDINGS:In response to ET-1, FBF decreased ~10% in the low (-10.0±2.3%), moderate (-10.7±4.0%), and high (-6.6±5.2%) CRP groups, with no significant differences between groups. Additionally, all groups demonstrated a marginal, though significant (~10%), vasodilator response to BQ-123; however, there were no differences in the FBF response to BQ-123 across CRP groups. There were no significant correlations between plasma CRP concentrations and peak FBF response to either ET-1 or BQ-123. SIGNIFICANCE:These results indicate that ET-1 system activity is not influenced by elevations in CRP. Enhanced ET-1 system activity may not be involved in the increased cardiovascular disease risk associated with elevations in plasma CRP concentrations.
journal_name
Life Scijournal_title
Life sciencesauthors
Dow CA,Templeton DL,Lincenberg GM,Greiner JJ,Stauffer BL,DeSouza CAdoi
10.1016/j.lfs.2015.12.030subject
Has Abstractpub_date
2016-08-15 00:00:00pages
66-70eissn
0024-3205issn
1879-0631pii
S0024-3205(15)30123-5journal_volume
159pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Oleuropein (Ole) is the main bioactive phenolic compound present in olive leaves, fruits and olive oil. This molecule has been shown to exert beneficial effects on several human pathological conditions. In particular, recent preclinical and observational studies have provided evidence that Ole exhibits chemo-preventiv...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118694
更新日期:2021-01-01 00:00:00
abstract::It has been previously shown that treatment of newborn rats with the polyamines putrescine, spermidine and spermine can rescue sympathetic neurons from naturally occurring cell death and from induced death after axotomy or immunosympathectomy. The present study demonstrates that polyamine treatment can also prevent th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90409-8
更新日期:1989-01-01 00:00:00
abstract::Extracts of Hypericum perforatum (St. John's wort) have antidepressant properties in depressed patients and exert antidepressant-like action in laboratory animals. The phloroglucinol derivative hyperforin has become a topic of interest, as this Hypericum component is a potent inhibitor of monoamines reuptake. The mole...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00295-9
更新日期:2003-06-13 00:00:00
abstract::Based on the finding of decreased mitochondrial complex I activity in the substantia nigra of patients with Parkinson's disease, we propose that the consequent reduction of ATP synthesis and increased generation of reactive oxygen species may be a possible cause of nigrostriatal cell death. Since sulfhydryl groups are...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(98)00472-x
更新日期:1999-01-01 00:00:00
abstract::The effects of aging on contractile response to angiotensin II and tachyphylaxis to it were investigated using aortic strips from rats aged 1.5, 4 and 22 months. Whether the endothelium was present or not, the contractile response to angiotensin II was greater and tachyphylaxis to it was less in 1.5-month-old rats tha...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90549-7
更新日期:1990-01-01 00:00:00
abstract::Prolidase deficiency seems to be a rather rare metabolic disorder. However, many new cases can be detected because screening is easy to perform and enzymatic confirmation allows the differentiation from other iminodipeptidurias . Clinical symptoms are briefly reviewed, while biological considerations and prolidase pro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90363-1
更新日期:1984-05-21 00:00:00
abstract::Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progressi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118509
更新日期:2020-12-01 00:00:00
abstract::Food allergies have become increasingly prevalent during the past few decades. Diarrhea is one of the most frequent intestinal symptoms caused by food allergens and is characterized by imbalanced ion exchange and water transfer; however, the underlying mechanism of allergic diarrhea remains unclear. Water transfer acr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.04.036
更新日期:2007-06-20 00:00:00
abstract::Active Hexose Correlated Compound (AHCC), an extract derived from fungi of Basidiomycetes family has been shown to act as a biological response modifier in various disorders. In our present study, ferric nitrilotriacetate (Fe-NTA), which generates hydroxyl radicals in vivo, was given intraperitoneally to rats and AHCC...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.06.038
更新日期:2003-12-19 00:00:00
abstract:AIMS:The study aimed to investigate whether IL-23 is amplified in monocyte subsets of MP pneumonia and to determine its relevant pathway. MATERIALS AND METHODS:We firstly analyze the IL-23p19 expression in monocyte subgroups in MP pneumonia patients and healthy controls subjects by using flow cytometry. Then, we also ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118149
更新日期:2020-10-01 00:00:00
abstract::We provide direct evidence that verapamil inhibits active digoxin secretion in renal tubular cells (LLC-PK1), and that verapamil increases cellular accumulation of digoxin. These findings suggest that verapamil inhibits the digoxin active secretory transport at the apical membranes, supporting the theory that P-glycop...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90667-r
更新日期:1993-01-01 00:00:00
abstract:AIMS:Multiple sclerosis (MS) whose pathogenesis is still unclear is a chronic progressive disease in the central nervous system. Gut microbiota can directly or indirectly affect the immune system through the brain gut axis to engage in the occurrence and development of the disease. MATERIALS AND METHODS:C57BL/6 mice w...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117747
更新日期:2020-07-15 00:00:00
abstract::Utilizing a nine amino-acid (Asp-Glu-Leu-Tyr-Pro-Leu-Glu-Val-Glu) non-enkephalin containing fragment of Peptide F from the pro-enkephalin molecule, a radioimmunoassay was developed. Extraction of bovine, rat, and guinea pig adrenomedullary preparations demonstrated this fragment to be present and apparently partially ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90232-6
更新日期:1982-10-18 00:00:00
abstract::Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. MCP-1 is found in macrophage-rich areas of atherosclerotic lesions. Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.06.019
更新日期:2007-07-26 00:00:00
abstract::The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00093-3
更新日期:1995-03-10 00:00:00
abstract::Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diab...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2017.10.025
更新日期:2018-01-15 00:00:00
abstract::Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2015.01.006
更新日期:2015-04-01 00:00:00
abstract::Psychostimulants including amphetamine and cocaine induce locomotion and stereotypy and suppress eating. Although the capacity of cocaine to alter locomotion is usually viewed as related to dopamine neurotransmission, recent studies suggest that norepinephrine, acting through alpha1-adrenergic receptors (alpha1-ARs) c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.08.004
更新日期:2007-09-08 00:00:00
abstract::Inhaled antimuscarinics, often called anticholinergics in clinical medicine, are established as first line bronchodilators in COPD. Tiotropium has been developed as a new generation antimuscarinic following ipratropium. Tiotropium is a specific, highly potent antimuscarinic, demonstrating very slow dissociation from m...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(98)00588-8
更新日期:1999-01-01 00:00:00
abstract::We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabeti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00231-7
更新日期:1996-01-01 00:00:00
abstract:AIMS:Several lines of evidence support the hypothesis that the oxidation of low density lipoprotein (LDL) may play a crucial role in the initiation and progression of atherosclerosis. Various studies have shown a positive effect of antioxidant compounds on oxidative modification of LDL and atherogenesis. In view of thi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.10.005
更新日期:2008-12-19 00:00:00
abstract::Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of tumor-associated proteins. Recent studies have found that KPNA2 is overexpressed in various cancers, which is associated with poor prognosis. In addition...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2019.117140
更新日期:2020-01-15 00:00:00
abstract::The binding characteristics of the sigma-1 selective benzomorphan [3H]-(+)-pentazocine were determined in human cerebellar membranes. Saturation binding analysis revealed two affinity sites with a KDH of 1.4 +/- 0.7 nM and a KDL of 33.6 +/- 11.9 nM. Kinetic studies performed at 25 degrees C demonstrated reversible bin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00322-x
更新日期:1994-01-01 00:00:00
abstract::The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.06.017
更新日期:2003-11-07 00:00:00
abstract::The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.05.043
更新日期:2016-07-15 00:00:00
abstract::We produced thiamine-deficient (TD) mice by TD diet treatment. The growth curve of mice on TD feeding was sharply increased until on the 10th day and subsequently the body weight gradually decreased. The mortality rate in mice was about 67% on the 30th day after the start of TD feeding. We performed the forced swimmin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01206-1
更新日期:2001-07-27 00:00:00
abstract::We investigated the mechanism underlying the priming effect of TNF-alpha on fMLP-stimulated superoxide production in human neutrophils. TNF-alpha enhanced fMLP-stimulated superoxide production in a concentration-dependent manner. TNF-alpha also induced sphingomyelin (SM) hydrolysis and increased the formation of its m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00587-1
更新日期:2000-01-01 00:00:00
abstract::NF-kappaB that plays an important role in iNOS expression is one of the targets of various potential anti-inflammatory agents including resveratrol. Resveratrol contains a structural similarity with estrogen, and there has been speculation about resveratrol as estrogen agonist. In this study, the mechanism and structu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01971-9
更新日期:2002-09-13 00:00:00
abstract::Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00128-s
更新日期:1995-01-01 00:00:00
abstract::Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS) - selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for ten months. Chronic ethanol exposure produced significant increases of dopamine and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90115-8
更新日期:1985-01-28 00:00:00