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Peptide F (pro-enkephalin fragment): radioimmunoassay, and stress-induced changes in adrenal.

Abstract：

:Utilizing a nine amino-acid (Asp-Glu-Leu-Tyr-Pro-Leu-Glu-Val-Glu) non-enkephalin containing fragment of Peptide F from the pro-enkephalin molecule, a radioimmunoassay was developed. Extraction of bovine, rat, and guinea pig adrenomedullary preparations demonstrated this fragment to be present and apparently partially conserved across species. In rats, acute inescapable foot-shock stress led to a significant decrease of the immunoreactive material in the adrenal medulla. Chronic daily stress for two weeks resulted in an inability of the adrenals to alter F levels upon subsequent stress. The existence of F-like immunoreactivity and its alteration by environmental manipulation, suggest that it may play a unique physiological role.

journal_name

Life Sci

journal_title

Life sciences

authors

Alessi N,Taylor L,Akil H

doi

10.1016/0024-3205(82)90232-6

subject

Has Abstract

pub_date

1982-10-18 00:00:00

pages

1875-8

issue

16-17

eissn

0024-3205

issn

1879-0631

pii

0024-3205(82)90232-6

journal_volume

31

pub_type

杂志文章

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