Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress.

abstract：:The effect of oral administration of Clostridium butyricum Miyairi on the formation and dissolution of gallstones was examined in a mouse model of cholesterol cholelithiasis, in comparison with that of chenodeoxycholic acid (CDCA). A diet containing cholesterol and sodium cholate was used as a lithogenic diet. The fee...

journal_title：Life sciences

authors： Takeda Y,Itoh H,Kobashi K

更新日期：1983-01-31 00:00:00

abstract：:The effects of pyrroloquinoline quinone (PQQ) and PQQ-oxazole (PQQ-glycine adduct) on DNA synthesis were examined using cultured human fibroblasts. Confluent fibroblasts were cultured in serum-free Dulbecco's modified Eagle's media, and various concentrations of PQQ and PQQ-oxazole were added to the media. After incub...

journal_title：Life sciences

authors： Naito Y,Kumazawa T,Kino I,Suzuki O

更新日期：1993-01-01 00:00:00

abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...

journal_title：Life sciences

authors： Atarashi K,Matsuoka H,Takagi M,Sugimoto T

更新日期：1989-01-01 00:00:00

abstract：AIMS:The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rat...

journal_title：Life sciences

authors： Grover GJ,Koetzner L,Wicks J,Gahler RJ,Lyon MR,Reimer RA,Wood S

更新日期：2011-02-28 00:00:00

abstract：:Hyperlipidemia and the glomerular accumulation of atherogenic lipoproteins (low density lipoprotein, LDL; and its oxidatively-modified variants, ox-LDL) are commonly associated with the development of glomerular mesangial proliferative diseases. However, cellular signaling mechanisms by which atherogenic lipoproteins ...

journal_title：Life sciences

authors： Kamanna VS,Bassa BV,Ganji SH

更新日期：2008-10-24 00:00:00

abstract：AIM:Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildaglip...

journal_title：Life sciences

authors： Nath M,Bhattacharjee K,Choudhury Y

更新日期：2021-02-01 00:00:00

abstract：:Tardive dyskinesia (TD) is a serious side-effect of neuroleptic treatment. In order to describe and analyse more thoroughly the rat model of TD, the behavior of the rats during cage testing was studied after acute and during long-term haloperidol (HAL) treatment. Rats were injected with HAL i.p. in an acute experiment...

journal_title：Life sciences

authors： Andreassen OA,Jørgensen HA

更新日期：1995-01-01 00:00:00

abstract：:We observed a significant increase in plasma atrial natriuretic factor (ANF) in antiorthostatic hypokinetic suspension (AOH) rats after 2 h of suspension when the experiment was made during day. Plasma ANF was investigated in relation to renal glomerular ANF receptors during AOH at night. The aim of this study was 1) ...

journal_title：Life sciences

authors： Gauquelin G,Schiffrin EL,Garcia R,Entresangles M,Cantin M,Gharib C

更新日期：1988-01-01 00:00:00

abstract：:The use of neuroleptic drugs to treat schizophrenia is almost invariably associated with extrapyramidal movement disorders. One of these disorders, tardive dyskinesia (TD), can persist long after neuroleptic withdrawal suggesting that permanent neurological damage is produced. However, there appears to be no convincin...

journal_title：Life sciences

authors： Eyles DW,Pond SM,Van der Schyf CJ,Halliday GM

更新日期：2000-02-25 00:00:00

abstract：:The ability of selective mu- ([D-Ala2, NHPhe4, Gly-ol]enkephalin: DAMGO), delta1- ([D-Pen2, Pen5]enkephalin: DPDPE) and delta2- ([D-Ala2]deltorphin II: DELT II) opioid receptor agonists to activate G-proteins in the midbrain and forebrain of mice and rats was examined by monitoring the binding of guanosine-5'-O-(3-[35...

journal_title：Life sciences

authors： Tsuji M,Narita M,Mizoguchi H,Narita M,Ohsawa M,Kamei J,Nagase H,Takeda H,Matsumiya T,Tseng LF

更新日期：1999-01-01 00:00:00

abstract：AIMS:Hyperthermia is a characteristic functional effect of sleep deprivation (SD). We hypothesize here that prostaglandin E2 (PGE2) could be involved in hyperthermia induced by sleep deprivation. MAIN METHODS:To address this issue we examined the effects of a selective cyclo-oxygenase-2 inhibitor (COX-2) agent on hype...

journal_title：Life sciences

authors： Palma BD,Nobrega JN,Gomes VL,Esumi LA,Seabra ML,Tufik S,Hipolide DC

更新日期：2009-02-27 00:00:00

abstract：:The effects of the d- and l-isomers of pentazocine were compared to that of racemic pentazocine on contractions of the mouse isolated vas deferens. L-pentazocine inhibited electrically evoked contractions of the mouse vas deferens (MVD) in a dose-dependent manner (ID50 0.37 +/- 0.04 microM). In contrast, d-pentazocine...

journal_title：Life sciences

authors： Kinouchi K,Fukumitsu K,Takezawa J,Maeda S,Enomoto H,Kakuhari J,Yoshiya I,Inoki R

更新日期：1986-07-14 00:00:00

abstract：AIMS:This study was performed to examine whether hypertension affects the sympathetic transmission to resistance vessels of pithed rats via inhibitory presynaptic cannabinoid CB1 receptors and whether endocannabinoids are involved in this response. MATERIALS AND METHODS:We compared uninephrectomised rats rendered hype...

journal_title：Life sciences

authors： Toczek M,Schlicker E,Grzęda E,Malinowska B

更新日期：2015-10-01 00:00:00

abstract：:The biosynthesis of digitalis-like compounds (DLC) was determined in bovine and rat adrenal homogenates, as well as in primary rat adrenal cells, by following changes in the concentration of DLC using three independent sensitive bioassays: inhibition of [3H]-ouabain binding to red blood cells and competitive ouabain a...

journal_title：Life sciences

authors： Lichtstein D,Steinitz M,Gati I,Samuelov S,Deutsch J,Orly J

更新日期：1998-01-01 00:00:00

abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...

journal_title：Life sciences

authors： Ubeda A,Díaz-Enriquez M,Martínez-Pascual MA,Parreño A

更新日期：1997-01-01 00:00:00

abstract：:The effects of exposure to ionizing radiation on the nociceptive thresholds of CF-1 mice were examined. Significant increases in thermal response latencies, indicative of analgesia were observed after exposure to either high or low doses of radiation. However, the onset of analgesia occurred significantly more rapidly...

journal_title：Life sciences

authors： Teskey GC,Kavaliers M

更新日期：1984-10-08 00:00:00

abstract：AIMS:With the improvement of the survival rates in children acute lymphoblastic leukemia (ALL), some children ALL survivors show impaired cognitive function. Methotrexate (MTX), an essential component in ALL treatment, has been reported to be related to neurologic sequelae and to increased oxidative stress through its ...

journal_title：Life sciences

authors： Chen YC,Sheen JM,Hsu MH,Hsiao CC,Wang SC,Huang LT

更新日期：2020-02-01 00:00:00

abstract：:Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...

journal_title：Life sciences

authors： Filloux F,Richards TJ,Huff GF,Wamsley JK

更新日期：1991-01-01 00:00:00

abstract：:Bovine brain phospholipid liposomes (BC-PL) reduce plasma prolactin (PRL) levels in humans after acute administration and counteract the metoclopramide- and sulpiride-induced hyperprolactinaemia. However, BC-PL, like nomifensine, a dopamine (DA) reuptake inhibitor and therefore an indirect dopaminergic compound, does ...

journal_title：Life sciences

authors： Falaschi P,Rocco A,D'Urso R,Jellamo R,Toffano I,Frajese G

更新日期：1982-07-05 00:00:00

abstract：:Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressu...

journal_title：Life sciences

authors： Ames JR,Ryan MD,Kovacic P

更新日期：1987-10-19 00:00:00

abstract：:To determine the mechanism of anoxic vasoconstriction, precontracted rat aortic rings were exposed to 95% N2, which caused additional contraction. Reoxygenation (95% O2) resulted in initial relaxation followed by contraction. Indomethacin did not affect anoxic contraction or reoxygenation-mediated events, but NG-monom...

journal_title：Life sciences

authors： Mehta JL,Lawson DL,Yang BC,Haught WH,Hintze T

更新日期：1991-01-01 00:00:00

abstract：:The bradykinin-induced sensitization of cutaneous nociceptors to heat was previously shown to be abolished by cyclooxygenase blockade suggesting that endogenous prostaglandins exerted a heat-sensitizing action. The present study aimed at investigating the effects of exogenous prostaglandin E(2) (PGE(2)) and I(2) (PGI(...

journal_title：Life sciences

authors： Derow A,Izydorczyk I,Kuhn A,Reeh PW,Petho G

更新日期：2007-12-14 00:00:00

abstract：:The modulation of Ca2+ release by synthetic bee venom melittin was examined in equine and human terminal cisternae-containing fractions. Melittin (0.1 microM) decreased the threshold of Ca(2+)-induced Ca2+ release by 20% in equine muscle and by 36% in human muscle. If terminal cisternae fractions were first preloaded ...

journal_title：Life sciences

authors： Fletcher JE,Tripolitis L,Beech J

更新日期：1992-01-01 00:00:00

abstract：:Tobacco smoke (TS) is a potent source of oxidants and oxidative stress is an important mechanism by which TS exerts its toxicity in the lung. We have shown that TS induces heat shock (HS)/stress protein (HSP) synthesis in human monocytes. Pulmonary surfactant (PS) whose major physiological function is to confer mechan...

journal_title：Life sciences

authors： Pinot F,Bachelet M,François D,Polla BS,Walti H

更新日期：1999-01-01 00:00:00

abstract：:The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy. Clomipramine and citalopram, at a concentration of 100 nM, decreased the peak values of 5-HT-induced [Ca2+]i changes. V...

journal_title：Life sciences

authors： Yamaji T,Kagaya A,Uchitomi Y,Yokota N,Yamawaki S

更新日期：1997-01-01 00:00:00

abstract：:Thalidomide (Thd) was given in two trials (total daily dose: 5 or 8 mg Thd/kg body weight, respectively) for five and three days to a healthy male volunteer, and various receptors were analyzed on white blood cells before, during and after (up to 30 days) the treatment period. There were neither marked deviations in t...

journal_title：Life sciences

authors： Neubert R,Nogueira AC,Neubert D

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To explore the effect of urantide on atherosclerotic myocardial injury by antagonizing the urotensin II/urotensin II receptor (UII/UT) system and regulating the mitogen-activated protein kinase (MAPK) signalling pathway. METHODS:Atherosclerosis (AS) was established in rats by administering a high-fat diet an...

journal_title：Life sciences

authors： Zhao J,Miao G,Wang T,Li J,Xie L

更新日期：2020-12-01 00:00:00

abstract：:Sweat glands are innervated by sympathetic neurons which undergo a change in transmitter phenotype from noradrenergic to cholinergic during development. As soon as the glands begin to differentiate, M3 muscarinic receptor mRNA and binding sites are detectable. Receptor expression appears in the absence of innervation ...

journal_title：Life sciences

authors： Landis SC

更新日期：1999-01-01 00:00:00

abstract：:This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on langua...

journal_title：Life sciences

authors： Normando VMF PhD,Dias ÁRN Me,da Silva ALSE Lic,da Silva Pinto D PhD,de Souza Santos MC PhD,Rodrigues CL Lic,de Oliveira EM PhD,de Souza Filho LEC Me,de Brito Vieira W Esp,Andriolo RB PhD,Sousa RCM PhD,Falcão LFM PhD,Quaresma JAS

更新日期：2020-09-01 00:00:00

abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...

journal_title：Life sciences

authors： Rehavi M,Weiss H,Nissenkorn I,Rubinstein R,Cohen S

更新日期：1987-05-04 00:00:00