Abstract:
AIMS:Hyperthermia is a characteristic functional effect of sleep deprivation (SD). We hypothesize here that prostaglandin E2 (PGE2) could be involved in hyperthermia induced by sleep deprivation. MAIN METHODS:To address this issue we examined the effects of a selective cyclo-oxygenase-2 inhibitor (COX-2) agent on hyperthermia induced by SD in rats. We also investigated binding to PGE2 receptors in hypothalamic brain areas of sleep-deprived rats using in vitro autoradiography. Male Wistar rats were deprived of sleep for 96 h using the platform technique. Sleep deprived and control groups received saline or Celecoxib (20, 30 and 40 mg/kg; p.o.) daily during the SD period. Colonic temperature was measured daily. KEY FINDINGS:Results indicated that core temperature of sleep-deprived rats that receiving saline increased from the first to the fourth day of SD compared to baseline and to the respective control group. However, the hyperthermia induced by SD was not blocked by COX-2 inhibitor at any dose. [(3)H]PGE2 binding did not differ significantly among the groups in any of a number of hypothalamic areas examined. SIGNIFICANCE:Although SD rats showed no response to the COX-2 inhibitor and no alterations in [(3)H]PGE2 binding, the possibility remains that other prostaglandin system and/or receptor subtypes may be altered by SD.
journal_name
Life Scijournal_title
Life sciencesauthors
Palma BD,Nobrega JN,Gomes VL,Esumi LA,Seabra ML,Tufik S,Hipolide DCdoi
10.1016/j.lfs.2008.12.009subject
Has Abstractpub_date
2009-02-27 00:00:00pages
278-81issue
9-10eissn
0024-3205issn
1879-0631pii
S0024-3205(08)00502-Xjournal_volume
84pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The aims of this study were to determine whether endothelin-1 (ET-1), a positive inotropic agent, altered the production of cyclic AMP (cAMP) in adult feline cardiac myocytes and to characterize the effect with respect to G-protein-coupling and calcium regulation of adenylyl cyclase. ET-1 inhibited basal and/or stimul...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02264-3
更新日期:1996-01-01 00:00:00
abstract::Clonidine, when administered for prolonged period showed no tolerance to its analgesic activity. Prior exposure to clonidine attenuated the tolerance development to morphine-induced analgesia and the supersensitivity to acetylcholine (ACh) in ileum during chronic morphine treatment. Further, acute administration of lo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90021-8
更新日期:1983-09-19 00:00:00
abstract:AIMS:Induction of heme oxygenase-1 (HO-1) has been widely accepted to be neuro-protective. This study aimed to examine whether hemin (a HO-1 inducer) attenuates neuronal damage in the hippocampus induced by orthotopic autologous liver transplantation (OALT) in adult rats. MAIN METHODS:Rats were randomly allocated into...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.05.021
更新日期:2015-08-15 00:00:00
abstract:AIMS:The aim of this study was to investigate the molecular mechanism underlying preterm white matter injury (WMI) via the identification and functional analysis of differentially expressed long non-coding RNAs (lncRNAs) and mRNAs. MAIN METHODS:A neonatal rat model of preterm WMI was established by ligating the common...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117815
更新日期:2020-08-15 00:00:00
abstract::Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.10.044
更新日期:2018-12-01 00:00:00
abstract::Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117994
更新日期:2020-09-15 00:00:00
abstract::The mechanism of spontaneous coronary contractions was investigated in the rabbit. Arteries with intact endothelium did not spontaneously contract. However, spontaneous coronary contractions were generated after the removal of the endothelium. NG-nitro-L-arginine methyl ester and methylene blue, the inhibitors of the ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00492-7
更新日期:1994-01-01 00:00:00
abstract::The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylact...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.02.025
更新日期:2006-07-04 00:00:00
abstract::Prenatal exposure to low concentrations of carbon monoxide (CO, 75 and 150 ppm from day 0 to day 20 of gestation), resulting in maternal blood HbCO concentrations equivalent to those maintained by human cigarette smokers, leads to subtle myelin alterations in the sciatic nerve of male rat offspring. The rapid growth s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00761-x
更新日期:2000-08-25 00:00:00
abstract:AIMS:Cerebral atrophy resulting from neurodegeneration is highly prevalent in individuals with diabetes; however, the underlying mechanisms for diabetic neurodegeneration are not fully understood. Here we hypothesized that hyperglycemia induces molecular signaling that favors induction of proliferation in post mitotic,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.05.019
更新日期:2018-07-15 00:00:00
abstract::Bu-Zhong-Yi-Qi-Tang (BZYQT), a Chinese herbal medicine, inhibited the proliferation of human hepatoma cell lines (Hep3B, HepG2 and HA22T) dose-dependently. The IC50s of BZYQT on the proliferation of Hep3B, HepG2 and HA22T were 432.5+/-31.8 microg/ml, 455.4+/-24.2 microg/ml, and 2284.3+/-77.2 microg/ml respectively on ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01226-7
更新日期:2001-08-17 00:00:00
abstract::LncRNA small nucleolar RNA host gene 3 (Snhg3) has been involved in cell proliferation and migration in malignant cells. However, its role in regulating functions of non-malignant cells has been hardly reported. Here, we found Snhg3 expression was sharply induced in primary brain microvascular endothelial cells (BMVEC...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116929
更新日期:2019-11-15 00:00:00
abstract:AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.02.035
更新日期:2019-03-15 00:00:00
abstract::To analyze the effects of diabetes mellitus on the vascular responsiveness to nitric oxide and thromboxane receptor stimulation, 2 mm long segments of basilar, coronary, renal and tail arteries from male and female, control (normoglycemic) and streptozotocin-induced diabetic rats, were prepared for isometric tension r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02444-x
更新日期:2003-02-14 00:00:00
abstract::The effect of 32 mM ascorbate on the time courses of phosphocreatine (PCr), inorganic phosphate (Pi), adenosine triphosphate (ATP) and intracellular pH in rat skeletal muscle during ischemia and reperfusion was investigated in vivo using 31P nuclear magnetic resonance (NMR) spectroscopy. Ascorbate was administered int...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00904-x
更新日期:1995-01-01 00:00:00
abstract:AIMS:Elevated levels of epidermal growth factor (EGF) receptor are observed on several human tumors, e.g. cervical carcinoma and mamma carcinomas. The natural ligand EGF is an alternative to established antibodies and tyrosine kinase inhibitors for targeting EGF receptor-overexpressing tumor cells for therapy. Conjugat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.11.012
更新日期:2011-01-31 00:00:00
abstract:AIM:There is a specific frequency of extremely low-frequency electromagnetic field (ELF-EMF) that promotes neuronal differentiation. Although several mechanisms are known to regulate ELF-EMF-induced neuronal differentiation, a key factor that mediates neurogenic potentials by the ELF-EMF is largely unknown. Also, the p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.02.022
更新日期:2014-04-25 00:00:00
abstract::To investigate the changes in the FSH receptor and the activin receptor during sexual maturation in rat testes, we examined the mRNA levels of the receptors by Northern blot analysis. With a full length rat activin receptor cRNA probe in this study, Northern blot analysis revealed two activin receptor mRNAs (6Kb and 3...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90575-n
更新日期:1993-01-01 00:00:00
abstract::The rate of oxidation of sparteine by the 9000 x g supernatant fraction of a human liver was measured in the presence of various drugs which exert cardiovascular effects. Hexamethonium, ouabain, caffeine and isoproterenol had no effect on this rate, while alprenolol, metoprolol, oxprenolol, propranolol, timolol, pindo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90332-1
更新日期:1984-01-02 00:00:00
abstract::Propentofylline (PPF) is a xanthine derivative with pharmacological effects that are distinct from those of classic methylxanthines. It depresses the activation of microglial cells and astrocytes, which is associated with neuronal damage during neural inflammation and hypoxia. Our previous studies showed that PPF impr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.02.028
更新日期:2016-03-01 00:00:00
abstract:AIMS:Centella asiatica has been used to treat kidney diseases in Chinese traditional medicine. Asiaticoside (an extraction of C. asiatica) exerts a variety of pharmacological effects including immunomodulatory and anti-inflammatory functions. However, the mechanism of asiaticoside in the treatment of renal diseases rem...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.07.010
更新日期:2013-09-03 00:00:00
abstract::There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lympho...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90607-q
更新日期:1992-01-01 00:00:00
abstract::The recently discovered highly specific delta opioid antagonist H-Tyr-Tic-Phe-Phe-OH (TIPP) was radiolabelled by catalytic tritiation of its precursor [Tyr (3', 5'-I2)1]TIPP. The tritiated ligand labelled rat brain membrane binding sites with a Kd value of 0.64 nM and a Bmax of 82 fmol/mg protein. Binding competition ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90649-n
更新日期:1993-01-01 00:00:00
abstract::Dialyzed aqueous extracts of plant pollen are widely used in the clinical practice of allergy for diagnostic and therapeutic purposes. The present investigation shows that such allergenic extracts are capable of consuming complement in every human serum, independent of the clinical condition. Complement is engaged by ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00101-x
更新日期:1997-01-01 00:00:00
abstract::Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding sites on rat brain synaptosomes, with a potency intermediate to other benzodiazepines (BDZs), and Hill coefficients near 1 in different brain regions. Incubation at 37 degrees C reduced prem...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90646-5
更新日期:1984-07-23 00:00:00
abstract::Two male adult rhesus monkeys were used and caged individually. The room was temperature-controlled having a light-dark period of 12/12 hours. The animals were rapidly immobilized and immediately anesthetized with ketamine i. m. (10 mg/kg of body weight). They were bled four times at 15, 30, 45 and 60 mins after the k...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90247-9
更新日期:1991-01-01 00:00:00
abstract::Diabetic retinopathy, a common secondary complication of diabetes mellitus, involves extensive damage to the retinal microvasculature. Retina, being a susceptible target, is highly prone to hyperglycemia-induced molecular damages. PPAR receptor, chiefly gamma subtype, mediates numerous responses related to glucose met...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.03.054
更新日期:2016-05-15 00:00:00
abstract::Initial acute behavioral studies in mice indicated that phencyclidine (PCP) produced marked motor impairment as measured by the inverted screen technique with an ED50 value of 4.1 muMole/kg (i.v.). Phenylcyclohexene (PC) was considerably less active with an ED50 value of 325 muMole/kg (i.v.). PCP was also shown to be ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90708-1
更新日期:1982-08-23 00:00:00
abstract::Treatment of primary cultured chondrocytes from rabbit articular cartilage with interleukin-1 (IL-1)alpha and plasminogen induced the production of pro-matrix metalloproteinase 1 (proMMP-1/interstitial collagenase), proMMP-3 (stromelysin 1) and proMMP-9 (gelatinase B), as well as their active forms. Human urinary tryp...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00261-6
更新日期:1998-01-01 00:00:00
abstract::Defects in the mitochondrial genome have been associated with Parkinson's and Alzheimer's disease, and apoptosis can be triggered by the presence of energetically compromised mitochondria. Thus, in this study we have examined whether the divalent cations Cu2+ and Mn2+ could influence mitochondrial function in vitro. M...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)00948-1
更新日期:2001-02-23 00:00:00