Abstract:
:The use of neuroleptic drugs to treat schizophrenia is almost invariably associated with extrapyramidal movement disorders. One of these disorders, tardive dyskinesia (TD), can persist long after neuroleptic withdrawal suggesting that permanent neurological damage is produced. However, there appears to be no convincing pathology of TD and its pathogenesis remains unknown. Findings that neuroleptics interfere with normal mitochondrial function and produce mitochondrial ultrastructural changes in the basal ganglia of patients and animals suggest that mitochondrial dysfunction plays a role in TD. We have established a model for persistent TD in baboons that appears to involve compromised mitochondrial function. In this study, we evaluated two animals treated for 41 weeks with a derivative of haloperidol and two treated with vehicle only. Treatment was then withdrawn and the animals observed for a further 17-18 weeks. Treated animals developed abnormal orofacial signs that were consistent with TD. These symptoms persisted during the drug-free period. The animals were euthanased, the brains perfused-fixed then post-fixed in 4% paraformaldehyde and the caudate and putamen prepared for electron microscopy. Regardless of whether mitochondria were located in neural soma, excitatory terminals, glia or in non-somal neuropil there was no consistent difference either in size or number between treated and control animals. Thus, even if mitochondria in striatal neurons undergo ultrastructural alterations during neuroleptic therapy, these changes do not persist after drug withdrawal.
journal_name
Life Scijournal_title
Life sciencesauthors
Eyles DW,Pond SM,Van der Schyf CJ,Halliday GMdoi
10.1016/s0024-3205(00)00442-2subject
Has Abstractpub_date
2000-02-25 00:00:00pages
1345-50issue
14eissn
0024-3205issn
1879-0631pii
S0024320500004422journal_volume
66pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::A novel beta-carboline with benzodiazepine-like properties has recently been synthesized. We compared the effect of the i.v. administration of this drug, ZK 93423, with diazepam on the activity of nigral pars reticulata neurons which are known to be very sensitive to the inhibitory effect produced by GABA-mimetics and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90333-x
更新日期:1987-04-06 00:00:00
abstract::A 21 amino acid peptide containing the prepropendothelin sequence from amino acids 110 to 130 and two intrachain disulfide bonds was synthesized and tested for biological activity in the following endothelin assays: 1.) a competition binding assay using [125I]ET-1 and dog heart membranes, 2.) three RIA's using 125I-ET...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90308-e
更新日期:1990-01-01 00:00:00
abstract::The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(99)00282-9
更新日期:1999-01-01 00:00:00
abstract::In primary cultured bovine adrenal chromaffin cells (BACC), pituitary adenylate cyclase activating polypeptide 1-38 (PACAP) produced a dose related increase in tyrosine hydroxylase (TH) Vmax when measured 48 hours after the beginning of the treatment; a significant increase was observed with 0.5 nM and the maximal ind...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00614-8
更新日期:1994-01-01 00:00:00
abstract::10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90466-g
更新日期:1993-01-01 00:00:00
abstract:AIMS:Fcγ receptor I (FcγRI/CD64) that is restrictedly expressed on monocytes and macrophages, acts as the single high-affinity receptor of immunoglobulin G (IgG) in human. The expression of FcγRI is positively correlated with immune inflammation. The primary aim of this study was to explore the effects of FcγRI express...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.06.015
更新日期:2018-08-15 00:00:00
abstract::The subcellular distribution of Gamma-aminobutyric acid (GABA) was studied in the rat oviduct. The highest content of GABA was found in the soluble fraction. The effect of chemical stimulation of the endogenous GABA efflux from the rat oviduct was examined. High K+ concentrations could not induce elevation of the GABA...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90079-i
更新日期:1993-01-01 00:00:00
abstract:AIMS:it has been suggested that Chromium (Cr), one of the essential minerals, can be beneficial to type 2 diabetic patients because it lowers blood glucose levels by improving various steps in insulin action. A few studies reported that Cr might also have some beneficial effects in people with type 1 diabetes mellitus ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.08.001
更新日期:2010-09-25 00:00:00
abstract:AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.04.018
更新日期:2015-08-15 00:00:00
abstract::The effects of 14-day physical exercise or iloprost treatment (0.5-2 ng/Kg/min) on endogenous nitric oxide production and neutrophil adhesion were evaluated in 20 patients with peripheral arterial occlusive disease (Fontaine Stage II). Peripheral venous blood samples and 4-h urine samples were collected before, immedi...
journal_title:Life sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0024-3205(99)00550-0
更新日期:1999-01-01 00:00:00
abstract::This study was designed to evaluate the synergistic cytotoxicity of herb prescription, Palgin, in adriamycin-treated cancer cells. The combination of Palgin and adriamycin synergistically augmented the cytotoxicity of Chang and HL-60 cells, but not in Hep3B and Alexander cells. The cytotoxicity of two drugs was reveal...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02039-8
更新日期:2002-10-04 00:00:00
abstract::Inert gas narcosis is a neurological syndrome appearing when humans or animals are exposed to hyperbaric inert gases (nitrogen, argon) composed by motor and cognitive impairments. Inert gas narcosis induces a decrease of the dopamine release at the striatum level, structure involved in the regulation of the extrapyram...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00183-8
更新日期:2003-05-02 00:00:00
abstract::Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) we...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90139-0
更新日期:1985-09-30 00:00:00
abstract::To investigate the changes in the FSH receptor and the activin receptor during sexual maturation in rat testes, we examined the mRNA levels of the receptors by Northern blot analysis. With a full length rat activin receptor cRNA probe in this study, Northern blot analysis revealed two activin receptor mRNAs (6Kb and 3...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90575-n
更新日期:1993-01-01 00:00:00
abstract::Three neurodegenerative diseases, Huntington's disease (HD), Kennedy's disease (hereditary spinobulbar muscular atrophy, SBMA), and type 1 spinocerebellar ataxia (SCA-1) have been found to share a common genetic defect: an unstable region of repeated CAG trinucleotides which are thought to be translated into a polyglu...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(94)90012-4
更新日期:1994-01-01 00:00:00
abstract::Although lipid peroxidation of biological samples may be assessed by different chemical and physical methods, those based on the measurement of malondialdehyde formed from the breakdown of endoperoxides during the last stages of the oxidation of a polyunsaturated fatty acid, appear as the most widely used. Among the v...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(91)90550-u
更新日期:1991-01-01 00:00:00
abstract:AIMS:Resveratrol (Res) which is a polyphenolic phytoalexin, has various biological properties. In the present study, we investigated whether Res extracted from Polygonum cuspidatum can reduce oxidative damage and cognitive impairment in senescence-accelerated mouse (SAM). MAIN METHODS:Senescence-accelerated mice were ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.08.033
更新日期:2012-10-29 00:00:00
abstract::We studied the effects of cAMP on cytokine (interferon-gamma plus tumor necrosis factor-alpha)-induced stimulation of tetrahydrobiopterin (BH4) synthesis in human umbilical vein endothelial cells (HUVEC). The cytokine mixture caused a marked increase in the biosynthesis and release of BH4 by HUVEC. Dibutyryl-cAMP prod...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01503-5
更新日期:2002-03-22 00:00:00
abstract:AIMS:Several experimental studies have demonstrated that removal of the spleen accelerates liver regeneration after partial hepatectomy. While the mechanism of splenectomy promotes liver regeneration by the improvement of the formation of tight junction and the establishment of hepatocyte polarity is still unknown. MA...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.11.032
更新日期:2018-01-01 00:00:00
abstract::Oxymorphazone (at doses of 50-200 mg/kg) was found to be a relatively weak antinociceptive drug in intact frog (Rana esculenta) when acetic acid was used as pain stimulus. Frogs remained analgesic for at least 48 hrs following oxymorphazone (200 mg/kg) administration. The ligand increased the latency of wiping reflex ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90302-0
更新日期:1989-01-01 00:00:00
abstract::Cystic fibrosis (CF) remains a major problem in human genetics and cell pathophysiology. It is a single gene trait caused by a mutation on the long arm of chromosome 7. Among its expressions are abnormal regulation of chloride channels and/or microobstructions in exocrine tissues. Here, evidence is presented that mito...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(89)90389-5
更新日期:1989-01-01 00:00:00
abstract::A set of synaptic proteins have been shown to be essential for the life cycle and exocytosis of synaptic vesicles at the nerve terminal. Recently, these proteins have also been identified in certain endocrine cells. Here we analysed the presence and location of some of these synaptic proteins in anterior pituitary cel...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01156-9
更新日期:1998-01-01 00:00:00
abstract::Rat aortic smooth muscle homogenates and membrane preparations contain a phospholipase C which hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2). We discovered that guanyl-5'yl-imidodiphosphate (Gpp(NH)p) activated the hydrolysis of exogenous PIP2 but not of phosphatidylinositol (PI) in rat aortic membranes. Furt...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90417-6
更新日期:1987-08-03 00:00:00
abstract::This study is aimed to investigate the effect of the prolonged intake of conspicuous amounts of licorice (LE), or its natural constituent glycyrrhizin (G) on murine liver CYP-catalyzed drug metabolism. For this purpose the modulation of the regio- and stereo-selective hydroxylation of testosterone, together with the u...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01154-5
更新日期:1998-01-01 00:00:00
abstract::Of primary interest for every enzyme is the identification of its physiological substrates. However, the vast structural diversity of endogenous metabolites, coupled with the overlapping activities of numerous enzymes, makes it difficult to deduce the identity of natural substrates for a given enzyme based on in vitro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.05.019
更新日期:2005-08-19 00:00:00
abstract::The effects of nicotine on normal physiological function are of increasing concern. Preliminary to studies on the effects of prenatal exposure to nicotine, we examined methods of administering nicotine to rats. Drinking water containing nicotine was not palatable to rats and was an unsatisfactory method in our hands, ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90020-8
更新日期:1987-04-27 00:00:00
abstract::The compound (+)-MR200 [(+)-methyl (1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate] is a sigma ligand with increased affinity and selectivity compared to the structurally related ligand haloperidol. From the results of a previous study on the modulation of a systemically ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.10.005
更新日期:2006-04-18 00:00:00
abstract::Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performanc...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01090-4
更新日期:1998-01-01 00:00:00
abstract::Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90463-5
更新日期:1982-02-01 00:00:00
abstract:AIMS:Skeletal muscle diseases have become to be the most common complication in patients with type 2 diabetic mellitus (T2DM). However, the effective therapies against skeletal muscle diseases are not yet available. Sulforaphane (SFN) is an organic isothiocyanate found in cruciferous plants. Our aim was to explore whet...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117823
更新日期:2020-08-15 00:00:00