Abstract：
:Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performance liquid chromatography with ultraviolet detection. Qualitative analysis revealed the presence of naltrexone in tissues from neonates, but not in rats of 2 and 10 days, that were transplacentally exposed to drug. These results confirm earlier reports showing that naltrexone, maternally administered, passes through the placenta and enters the fetus. Moreover, the data suggest that the somatic and neurobiological acceleration observed in offspring exposed to naltrexone during gestation is not due to opioid receptor blockade during the postnatal period.
journal_name
Life Scijournal_title
Life sciencesauthors
Zagon IS,Hurst WJ,McLaughlin PJdoi
10.1016/s0024-3205(97)01090-4subject
Has Abstractpub_date
1998-01-01 00:00:00pages
221-8issue
3eissn
0024-3205issn
1879-0631pii
S0024320597010904journal_volume
62pub_type
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