Abstract：
:Platelet functions are becoming the useful tool for delineating the etiology of pregnancy induced hypertension. Electronmicroscopic studies, efflux and content of 5-HT in platelets and platelet aggregation responses towards various aggregating agents have been measured in 25 normotensive pregnant subjects and 31 PIH subjects. Marked decrease changes have been noted in aggregation parameters with transformation from discoid to "spiny sphere" of platelets with long pseudopods along with prolonged time for spontaneous aggregation by platelets in PIH. Serotonin release from platelets was decreased and reserpine-induced release-reaction showed enhanced kinetics in PIH. Platelet serotonin content was raised and was inversely related to platelet count with severity of syndrome. Hence, a check and balance for platelet activation and aggregation in PIH might be crucial in the development of PIH.
journal_name
Life Scijournal_title
Life sciencesauthors
Gujrati VR,Goyal A,Gaur SP,Singh N,Shanker K,Chandravatidoi
10.1016/0024-3205(94)00735-7subject
Has Abstractpub_date
1994-01-01 00:00:00pages
327-35issue
4eissn
0024-3205issn
1879-0631pii
0024-3205(94)00735-7journal_volume
55pub_type
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