当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury.

Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury.

Abstract：

:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75 mg/kg: (T2) and 9.75 mg/kg: (T3)] 6 days/week for 4 weeks. At the end of this period, all the animals, except the normal untreated rats that served as the control group, were administered isoproterenol (ISO) 85 mg/kg, S.C., for two consecutive days to induce in vivo myocardial injury. After 48 hours rats were anaesthetized with anaesthetic ether, then sacrificed and the hearts were harvested for biochemical and histological studies. A significant rise in myocardial thiobarbituric acid reactive substances (TBARS) and loss of reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (suggestive of increased oxidative stress) occurred in the hearts subjected to in vivo myocardial ischemic reperfusion injury. The 6.75 mg/kg TAAE treatment group (baseline) shows a significant increase in myocardial TBARS as well as endogenous antioxidants (GSH, SOD, and catalase), but not in the other treatment groups. In in vivo ischemic reperfusion injury of the TAAE treated rats there was a significant decrease in TBARS in all the groups. In 6.75 mg/kg treatment group, a significant rise in the levels of GSH, SOD and catalase were observed, and it shows better recovery profile than the other groups subjected to in vivo ischemic reperfusion injury. In histological studies, all the groups, except the isoproterenol treated group, showed preserved myocardium. The present study demonstrates that the 6.75 mg/kg TAAE augments endogenous antioxidant compounds of the rat heart and also prevents the myocardium from isoproterenol induced myocardial ischemic reperfusion injury.

journal_name

Life Sci

journal_title

Life sciences

authors

Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

doi

10.1016/s0024-3205(03)00671-4

subject

Has Abstract

pub_date

2003-10-10 00:00:00

pages

2727-39

issue

21

eissn

0024-3205

issn

1879-0631

pii

S0024320503006714

journal_volume

73

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • New insights on possible vaccine development against SARS-CoV-2.

    abstract：:In December 2019, a novel virus, namely COVID-19 caused by SARS-CoV-2, developed from Wuhan, (Hubei territory of China) used its viral spike glycoprotein receptor-binding domain (RBD) for the entrance into a host cell by binding with ACE-2 receptor and cause acute respiratory distress syndrome (ARDS). Data revealed th...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.118421

    authors： Chaudhry SN,Hazafa A,Mumtaz M,Kalsoom U,Abbas S,Kainaat A,Bilal S,Zafar N,Siddique A,Zafar A

    更新日期：2020-11-01 00:00:00

  • Modification of the effects of 7-OH-DPAT, a dopamine D3-receptor agonist, on morphine-induced hyperlocomotion by diabetes.

    abstract：:We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00363-3

    authors： Kamei J,Saitoh A

    更新日期：1996-01-01 00:00:00

  • Sodium nitroprusside activates p38 mitogen activated protein kinase through a cGMP/PKG independent mechanism.

    abstract：:The objective of this study was to understand the mechanism of action of nitric oxide (NO) in the heart by determining whether nitric oxide (NO) released from sodium nitroprusside (SNP) induces p38 mitogen activated protein kinase (p38 MAPK) phosphorylation and whether this is mediated through a cyclic GMP (cGMP)/prot...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.06.022

    authors： Rabkin SW,Klassen SS,Tsang MY

    更新日期：2007-08-02 00:00:00

  • The fos proto-oncogene protein:regulation by morphine in the rat hypothalamus.

    abstract：:Mechanisms by which opiates alter neuronal functions, including neuroendocrine functions, are not well defined. We have previously demonstrated that morphine rapidly and transiently increases expression of the proto-oncogene c-fos in the rat caudate-putamen. This regulation of the c-fos gene by morphine may represent ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90233-h

    authors： Chang SL,Harlan RE

    更新日期：1990-01-01 00:00:00

  • Alterations of plasma opioid activity in human diabetics.

    abstract：:Plasma opioid levels were determined in 9 obese non-diabetic subjects, their 8 age matched controls, and in 29 diabetic patients; 10 maintained on diet alone, 6 on an oral hypoglycemic agent (chlorpropamide) and 13 treated with insulin. Five age matched controls for the diabetic groups were also studied for comparison...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90364-3

    authors： Awoke S,Voyles NR,Bhathena SJ,Tanenberg RJ,Recant L

    更新日期：1984-05-21 00:00:00

  • Antihepatoma activity of Physalis angulata and P. peruviana extracts and their effects on apoptosis in human Hep G2 cells.

    abstract：:Physalis angulata and P. peruviana are herbs widely used in folk medicine. In this study, the aqueous and ethanol extracts prepared from the whole plant of these species were evaluated for their antihepatoma activity. Using XTT assay, three human hepatoma cells, namely Hep G2, Hep 3B and PLC/PRF/5 were tested. The res...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.09.058

    authors： Wu SJ,Ng LT,Chen CH,Lin DL,Wang SS,Lin CC

    更新日期：2004-03-05 00:00:00

  • Intestinal epithelial cells and musculature contain different muscarinic binding sites.

    abstract：:Muscarinic receptors on epithelial cells mediate intestinal secretion, while those in intestinal smooth muscle mediate motility. Experiments were carried out to determine whether the muscarinic receptors mediating each of these two functions in intestinal tissue might be associated with differences in the way agonist ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90444-8

    authors： Tien XY,Wahawisan R,Wallace LJ,Gaginella TS

    更新日期：1985-05-20 00:00:00

  • Effect of fish oil and vitamin E on ethanol-induced changes in membrane ATPases.

    abstract：:We evaluated whether fish oil or vitamin E administration affected ethanol-induced changes in membrane ATPases. Male Wistar rats (225-250 g) were fed, through a gastric tube a liquid diet containing fish oil (25% of calories) and ethanol for one month. Another group of animals was given supplemental vitamin E (300 u/k...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00545-1

    authors： Nanji AA,Sadrzadeh SM

    更新日期：1994-01-01 00:00:00

  • Expression of ER-α and ER-β during peri-implantation period in uterus is essential for implantation and decidualization in golden hamster.

    abstract：AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.12.002

    authors： Kumar R,Yadav A,Pakrasi PL

    更新日期：2017-02-01 00:00:00

  • Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis.

    abstract：AIMS:Naturally-derived farnesol has been reported for its chemopreventive and chemotherapeutic efficacy in various cancers. However, the mechanism of action of farnesol is still to be elucidated. The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2009.05.008

    authors： Chaudhary SC,Alam MS,Siddiqui MS,Athar M

    更新日期：2009-07-31 00:00:00

  • Interaction of tocopherols and phenolic compounds with membrane lipid components: evaluation of their antioxidant activity in a liposomal model system.

    abstract：:This paper describes the use of complex liposomes as real membrane models to evaluate the potential benefits of several antioxidants in relation to lipid peroxidation. The xanthine oxidase/Fe(3+)-ADP-EDTA and the Fe(2+)/H2O2 systems have been used to generate hydroxyl radicals and the water soluble azo-compound 2,2'-a...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(03)00120-6

    authors： Gutiérrez ME,García AF,Africa de Madariaga M,Sagrista ML,Casadó FJ,Mora M

    更新日期：2003-04-11 00:00:00

  • CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats.

    abstract：:Diazepam (0.4-4 mg/kg i.p.) reduced the spontaneous tonic activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus muscle of spastic mutant Han-Wistar rats in a dose-dependent manner. The muscle relaxant effect of diazepam was antagonized by the benzodiazepine antagonists Ro 15-1788 (5 mg/kg i.p.), ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90160-7

    authors： Schwarz M,Turski L,Sontag KH

    更新日期：1984-10-01 00:00:00

  • Effects of losartan, a nonpeptide angiotensin II receptor antagonist, on cardiac hypertrophy and the tissue angiotensin II content in spontaneously hypertensive rats.

    abstract：:Losartan, a recently developed nonpeptide angiotensin II (Ang II) receptor antagonist, was administered orally to 10-week-old spontaneously hypertensive rats (SHR) for 2 weeks. Cardiac weight and tissue Ang II, as well as plasma renin activity (PRA) and Ang II, were determined. Treatment with Losartan (10 mg/kg per da...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90589-h

    authors： Mizuno K,Tani M,Hashimoto S,Niimura S,Sanada H,Watanabe H,Ohtsuki M,Fukuchi S

    更新日期：1992-01-01 00:00:00

  • Effects of (-)-epigallocatechin-3-gallate in Ca2+ -permeable non-selective cation channels and voltage-operated Ca2+ channels in vascular smooth muscle cells.

    abstract：:The effects of (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of tea, on Ca(2+)-permeable non-selective cation currents (NSCC) and voltage-operated Ca(2+) channels (VOCC) have been investigated in cultured rat aortic smooth muscle cells using the whole-cell voltage-clamp technique. Under the Cs(+)/t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.04.005

    authors： Campos-Toimil M,Orallo F

    更新日期：2007-05-16 00:00:00

  • Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats.

    abstract：AIMS:Inducible nitric oxide synthase (iNOS) pathway has been in the limelight since its discovery as a key mediator in the process of liver fibrogenesis. Therefore, the objective of the current study was to elucidate the in vivo molecular mechanism underlying the hepatic preventive relevance of eugenol (EUG) and telmis...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.11.031

    authors： Fathy M,Khalifa EMMA,Fawzy MA

    更新日期：2019-01-01 00:00:00

  • Pharmacological activity and toxicity of phencyclidine (PCP) and phenylcyclohexene (PC), a pyrolysis product.

    abstract：:Initial acute behavioral studies in mice indicated that phencyclidine (PCP) produced marked motor impairment as measured by the inverted screen technique with an ED50 value of 4.1 muMole/kg (i.v.). Phenylcyclohexene (PC) was considerably less active with an ED50 value of 325 muMole/kg (i.v.). PCP was also shown to be ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90708-1

    authors： Holsapple MP,Munson AE,Freeman AS,Martin BR

    更新日期：1982-08-23 00:00:00

  • Age-associated changes and sex differences in urinary 6-sulphatoxymelatonin circadian rhythm in the rat.

    abstract：:The circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been determined in male and female rats at 3 weeks and at 2, 8, 14 and 20 months of age. All animals have a pronounced circadian pattern of aMT6s excretion under a 12 hour dark: 12 hour light cycle. A significant increase in aMT6s excretion is observe...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90323-h

    authors： Yie SM,Liu GY,Johansson E,Brown C,Brown GM

    更新日期：1992-01-01 00:00:00

  • Actinomycin D inhibition of monoclonal antibody binding to nucleolar phosphoprotein 37/5.2 (B23).

    abstract：:Actinomycin D was found to block binding of a monoclonal antibody to nucleolar phosphoprotein 37/5.2 (B23) when incubated either simultaneously with or prior to addition of the antibody. Daunorubicin had no significant blocking activity of this antigen-antibody reaction. In comparative studies with a monoclonal antibo...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90275-3

    authors： Busch RK,Chan PK,Busch H

    更新日期：1984-10-22 00:00:00

  • Calcium-activated and voltage-dependent potassium conductances in clonal pituitary cells.

    abstract：:Voltage clamp recordings of GH3/B6 pituitary cells reveal the presence of non linear steady state membrane properties at the level of the resting potential (about -41 mV). Clamping the cells to potentials more depolarized than -60 mV is associated with a potential dependent increase in membrane conductance and membran...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90475-1

    authors： Dufy B,Barker JL

    更新日期：1982-05-31 00:00:00

  • Anti-curare effect of plasma from patients with thermal injury.

    abstract：:Following severe thermal injury, patients are resistant to non-depolarizing muscle relaxants. Although this resistance has been well documented clinically, little is known about its etiology. We have tested the hypothesis that circulating factors contribute to the decreased potency of neuromuscular blockers following ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90234-2

    authors： Storella RJ,Martyn JA,Bierkamper GG

    更新日期：1988-01-01 00:00:00

  • Effects of anandamide on gestation in pregnant rats.

    abstract：:The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.p./day, re...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00296-8

    authors： Wenger T,Fragkakis G,Giannikou P,Probonas K,Yiannikakis N

    更新日期：1997-01-01 00:00:00

  • Oleic acid protects against cadmium induced cardiac and hepatic tissue injury in male Wistar rats: A mechanistic study.

    abstract：AIMS:The aim of the present study was to evaluate the possible antioxidant role of oleic acid (OA) against Cd-induced injuries in the heart and liver tissues of male Wistar rats. MAIN METHODS:Rats were treated with either vehicle (control), or OA (10 mg/kg b.w., fed orally), or Cd (0.44 mg/kg b.w., s.c.), or both (OA ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117324

    authors： Bhattacharjee B,Pal PK,Chattopadhyay A,Bandyopadhyay D

    更新日期：2020-03-01 00:00:00

  • Modulatory mechanisms of NLRP3: Potential roles in inflammasome activation.

    abstract：:The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studie...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.118918

    authors： Ge Q,Chen X,Zhao Y,Mu H,Zhang J

    更新日期：2021-02-15 00:00:00

  • Vitamin D3 attenuates lipopolysaccharide-induced cognitive impairment in rats by inhibiting inflammation and oxidative stress.

    abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117703

    authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

    更新日期：2020-07-15 00:00:00

  • DUSP1/MKP-1 regulates proliferation and apoptosis in keratinocytes through the ERK/Elk-1/Egr-1 signaling pathway.

    abstract：:Psoriasis is an inflammatory skin disease with preference for the skin and joints that occurs due to hyper-proliferation and abnormal apoptosis of keratinocytes. DUSP1 expression in dermal mesenchymal stem cells (MSCs) is obviously lower in psoriasis patients than that in healthy individuals. The present study aimed t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.03.018

    authors： Yang J,Sun L,Han J,Zheng W,Peng W

    更新日期：2019-04-15 00:00:00

  • Characterization of GABAA receptor-mediated 36chloride uptake in rat brain synaptoneurosomes.

    abstract：:gamma-Aminobutyric acid (GABA) receptor-mediated 36chloride (36Cl-) uptake was measured in synaptoneurosomes from rat brain. GABA and GABA agonists stimulated 36Cl- uptake in a concentration-dependent manner with the following order of potency: Muscimol greater than GABA greater than piperidine-4-sulfonic acid (P4S)gr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90207-4

    authors： Luu MD,Morrow AL,Paul SM,Schwartz RD

    更新日期：1987-09-07 00:00:00

  • Different effects of three kinds of somatostatin (15-28, 1-14, 1-28) on rabbit's platelet aggregation.

    abstract：:We studied the different effects of three kinds of somatostatin (somatostatin 1-14, somatostatin 15-28, somatostatin 1-28) on the aggregation of rabbit's platelets. It was clarified that somatostatin 15-28 had inhibitory effects on rabbit's platelet aggregation stronger than somatostatin 1-14 did, and that somatostati...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90455-2

    authors： Fuse I,Ito S,Takagi A,Shibata A

    更新日期：1985-05-27 00:00:00

  • Effect on intestinal transit of neurotensin administered intracerebroventricularly to rats.

    abstract：:Neurotensin (NT) administered intracerebroventricularly (i.c.v.) to rats, blocks intestinal transit (tested by charcoal meal) in linear relation to the log of the doses within the range of 0.6-2.5 nmoles/rat. NT in this test is about 40 times more active than morphine (M) and 6 times less active than dermorphin (DM) o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90547-7

    authors： Parolaro D,Sala M,Crema G,Spazzi L,Gori E

    更新日期：1983-01-01 00:00:00

  • Hyperbaric oxygen induces placental growth factor expression in bone marrow-derived mesenchymal stem cells.

    abstract：:The bone marrow is home to mesenchymal stem cells (MSCs) that are able to differentiate into many different cell types. The effect of hyperbaric oxygen (HBO) on MSCs is poorly understood. Placental growth factor (PlGF) is an attractive therapeutic agent for stimulating revascularization of ischemic tissue. HBO has bee...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.05.005

    authors： Shyu KG,Hung HF,Wang BW,Chang H

    更新日期：2008-07-04 00:00:00

  • Hematological changes in rats exposed to weak electromagnetic fields.

    abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00770-4

    authors： Ubeda A,Díaz-Enriquez M,Martínez-Pascual MA,Parreño A

    更新日期：1997-01-01 00:00:00