Abstract：
:The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studies have focused on specifically targeting NLRP3 to develop inhibitors against NLRP3 inflammasome. Here, we succinctly review the regulation of NLRP3 expression at DNA/chromosome, transcriptional, post-transcriptional, and translation levels. These are critical for the fine regulation of the NLRP3 inflammasome.
journal_name
Life Scijournal_title
Life sciencesauthors
Ge Q,Chen X,Zhao Y,Mu H,Zhang Jdoi
10.1016/j.lfs.2020.118918subject
Has Abstractpub_date
2021-02-15 00:00:00pages
118918eissn
0024-3205issn
1879-0631pii
S0024-3205(20)31678-7journal_volume
267pub_type
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