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Effect on intestinal transit of neurotensin administered intracerebroventricularly to rats.

Abstract：

:Neurotensin (NT) administered intracerebroventricularly (i.c.v.) to rats, blocks intestinal transit (tested by charcoal meal) in linear relation to the log of the doses within the range of 0.6-2.5 nmoles/rat. NT in this test is about 40 times more active than morphine (M) and 6 times less active than dermorphin (DM) on a molar basis. Within this dose range NT does not induce analgesia (tail-flick test) or hypothermia (tested at 22 degrees C). The intestinal effect can also be elicited by injecting the peptide into the periaqueductal gray matter (PAG). NT injected intraperitoneally (i.p.) is inactive up to doses 4 times the maximal active i.c.v. dose. Naloxone (Nx) and dynorphin 1-13 could not antagonize the intestinal effect of i.c.v. NT. The relationship between this central intestinal effect and many other central effects of NT is discussed.

journal_name

Life Sci

journal_title

Life sciences

authors

Parolaro D,Sala M,Crema G,Spazzi L,Gori E

doi

10.1016/0024-3205(83)90547-7

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

485-8

eissn

0024-3205

issn

1879-0631

pii

0024-3205(83)90547-7

journal_volume

33 Suppl 1

pub_type

杂志文章

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