Abstract:
:Buddlejasaponin I and saikosaponin 1 and 2, biologically active compounds from Scrophularia scorodonia and Bupleurum rigidum respectively, exert potent in vivo antiinflammatory effects on mouse ear edema induced by phorbol myristate acetate (PMA). The effects of these compounds on swelling and other inflammatory parameters are described. In screening for in vitro effects of saikosaponins on cellular systems generating cyclooxygenase (COX) and lipoxygenase (LOX) metabolites, we observed that most saikosaponins showed a significant effect. The action is more marked on LOX metabolite LTC4. Our data support the inhibition of arachidonic acid metabolism as one of the biochemical mechanisms that might be the rationale for the putative antiphlogistic activity of these saikosaponins.
journal_name
Life Scijournal_title
Life sciencesauthors
Bermejo Benito P,Abad Martínez MJ,Silván Sen AM,Sanz Gómez A,Fernández Matellano L,Sánchez Contreras S,Díaz Lanza AMdoi
10.1016/s0024-3205(98)00376-2subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1147-56issue
13eissn
0024-3205issn
1879-0631pii
S0024320598003762journal_volume
63pub_type
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