当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Thiorphan potentiation of stress-induced analgesia in the mouse.

Thiorphan potentiation of stress-induced analgesia in the mouse.

Abstract：

:Experiments were done to examine the analgesic effect of thiorphan alone or in combination with stress in mice. Analgesia was assessed by measuring jump latencies from a 55 degrees C hot plate. Thiorphan exhibited weak analgesic properties evidenced by significant increases in jump latencies only after 300 mg/kg i.p. Additional experiments were done to see the effect of i.c.v. administration of thiorphan in the mouse hot plate test. Control experiments revealed that either i.c.v. saline or sham caused naloxone reversible analgesia which was potentiated by thiorphan (100 mg/kg i.p.). Immobilization stress-induced analgesia was also potentiated by thiorphan (100 mg/kg i.p.) and antagonized by naloxone (10 mg/kg i.p.). The results suggest that stress-induced analgesia in the mouse is associated with an endogenous opioid mechanism which is potentiated when enkephalin degradation is inhibited by thiorphan.

journal_name

Life Sci

journal_title

Life sciences

authors

Greenberg R,O'Keefe EH

doi

10.1016/0024-3205(82)90338-1

subject

Has Abstract

pub_date

1982-09-20 00:00:00

pages

1185-8

issue

12-13

eissn

0024-3205

issn

1879-0631

pii

0024-3205(82)90338-1

journal_volume

31

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Toll-like receptor 4 expressions on peripheral blood monocytes were enhanced in coronary artery disease even in patients with low C-reactive protein.

    abstract：:Toll-like receptors (TLRs) play important roles in the pathogenesis of atherosclerosis. On the other hand, serum high sensitivity C-reactive protein (hsCRP) is known as an independent coronary risk factor, but cardiovascular events do occur even in low hsCRP levels. We investigated whether the TLR4 expression levels o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.08.027

    authors： Shiraki R,Inoue N,Kobayashi S,Ejiri J,Otsui K,Honjo T,Takahashi M,Hirata K,Yokoyama M,Kawashima S

    更新日期：2006-12-03 00:00:00

  • Bovine adrenals and hypothalamus are a major source of proscillaridin A- and ouabain-immunoreactivities.

    abstract：:Besides an isomer of the cardenolide ouabain, a material with a similar HPLC retention time as ouabain but cross-reactivating with antibodies against the bufadienolide proscillaridin A and inhibiting the sodium pump is known to circulate in human blood plasma (B. SICH et al., Hypertension 27, 1073-1078 (1996).). The c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00023-x

    authors： Li S,Eim C,Kirch U,Lang RE,Schoner W

    更新日期：1998-01-01 00:00:00

  • Multi-omics analysis of copy number variations of RNA regulatory genes in soft tissue sarcoma.

    abstract：AIMS:RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation (CNV) is a frequent characteristic in soft tissue sarcomas (STS). However, little is known regarding their possible roles in STS. MAIN METHODS:RNA sequence profiles and CNV data of 255 STS patie...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118734

    authors： Wang X,Han Y,Li J,Hong D,Xue Z,Huang H,Du Z,Hou Y,Li H,Li H,Liao H,Xie X,Ding C

    更新日期：2021-01-15 00:00:00

  • Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for KATP channel.

    abstract：AIMS:Although approving new anticonvulsants was a major breakthrough in the field of epilepsy control, so far we have met limited success in almost one third of patients suffering from epilepsy and a definite and reliable method is yet to be found. Levosimendan demonstrated neuroprotective effects and reduced mortality...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.11.006

    authors： Gooshe M,Tabaeizadeh M,Aleyasin AR,Mojahedi P,Ghasemi K,Yousefi F,Vafaei A,Amini-Khoei H,Amiri S,Dehpour AR

    更新日期：2017-01-01 00:00:00

  • Chemokines and their receptors in the brain: pathophysiological roles in ischemic brain injury.

    abstract：:Chemokines constitute a large family of structurally-related small cytokines originally identified as factors regulating the migration of leukocytes in inflammatory and immune responses. Production of chemokines and their receptors in the brain has been reported under various pathological conditions. We revealed that ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2003.09.019

    authors： Minami M,Satoh M

    更新日期：2003-12-05 00:00:00

  • The biological significance of malondialdehyde determination in the assessment of tissue oxidative stress.

    abstract：:Although lipid peroxidation of biological samples may be assessed by different chemical and physical methods, those based on the measurement of malondialdehyde formed from the breakdown of endoperoxides during the last stages of the oxidation of a polyunsaturated fatty acid, appear as the most widely used. Among the v...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(91)90550-u

    authors： Valenzuela A

    更新日期：1991-01-01 00:00:00

  • Prostate tumor CXC-chemokine profile correlates with cell adhesion to endothelium and extracellular matrix.

    abstract：:Though chemokines of the CXC family are thought to play key roles in neoplastic transformation and tumor invasion, information about CXC chemokines in prostate cancer is sparse. To evaluate the involvement of CXC chemokines in prostate cancer, we analyzed the CXC coding mRNA of both chemokine ligands (CXCL) and chemok...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.08.019

    authors： Engl T,Relja B,Blumenberg C,Müller I,Ringel EM,Beecken WD,Jonas D,Blaheta RA

    更新日期：2006-03-13 00:00:00

  • Self-administration of dynorphin-[1-13] and D-ala2-dynorphin-[1-11] (kappa opioid agonists) in morphine (mu opioid agonist)-dependent rats.

    abstract：:Adult female Sprague-Dawley rats were prepared with permanent cortical EEG and temporalis EMG electrodes and i.v. cannulae. They were made tolerant to and physically dependent on morphine by automatic, hourly injections. These physically dependent rats were then trained to lever press for 10 mg/kg injections of morphi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90564-7

    authors： Khazan N,Young GA,Calligaro D

    更新日期：1983-01-01 00:00:00

  • Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.

    abstract：:This study was undertaken to examine the receptor selectivity of Met-enkephalin-Arg6-Phe7 (MERF) employing radioreceptor binding assays in human cerebral cortex membranes, and to elucidate the responsible receptors that mediate the regulatory action of MERF on high (20 mM) K+-stimulated release of [3H]norepinephrine (...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00606-8

    authors： Kim KW,Woo RS,Kim CJ,Cheong YP,Kim JK,Kwun J,Cho KP

    更新日期：2000-05-26 00:00:00

  • Ethanol potentiates heat response in the carotid artery via TRPV1.

    abstract：AIM:Ethanol is one of the most widely used recreational drugs in the world. At high concentrations, it can induce carotid artery vasoconstriction. Hyperthermia potentiates its effects resulting in carotid artery vasoconstriction at any concentration. The aim of this study is to investigate the interaction between ethan...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.08.037

    authors： Mustafa S,Ismael HN

    更新日期：2017-11-01 00:00:00

  • The pharmacokinetics and liver metabolism of N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA) in rats.

    abstract：:The metabolism and disposition of N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA) was studied by utilizing rat liver slices as well as by intravenous pharmacokinetic studies in rats. In the liver slice experiments, N-OH MDA (16 micrograms/ml) was incubated with rat liver slices and the disappearance of N-OH MDA and...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00726-8

    authors： Ravis WR,Valaer AK,Brzozowski D,Clark CR

    更新日期：1994-01-01 00:00:00

  • Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion.

    abstract：:High concentrations of cocaethylene (EC), the ethyl ester of benzoylecgonine, were measured in the blood of individuals who had concurrently used cocaine and ethanol. Since the powerful reinforcing effects of cocaine appear to be dependent on inhibition of dopamine reuptake in brain, we compared the effects of EC on t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90217-y

    authors： Jatlow P,Elsworth JD,Bradberry CW,Winger G,Taylor JR,Russell R,Roth RH

    更新日期：1991-01-01 00:00:00

  • Brief debrisoquin administration to assess central dopaminergic function in children.

    abstract：:Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90239-0

    authors： Riddle MA,Shaywitz BA,Leckman JF,Anderson GM,Shaywitz SE,Hardin MT,Ort SI,Cohen DJ

    更新日期：1986-03-17 00:00:00

  • Effects of levetiracetam on blood-brain barrier disturbances following hyperthermia-induced seizures in rats with cortical dysplasia.

    abstract：AIMS:The mechanisms underlying the changes in blood-brain barrier (BBB) integrity and the generation of seizures in childhood associated with preexisting brain lesions like cortical dysplasia (CD) are poorly understood. We investigated the effects of levetiracetam (LEV) on BBB integrity and the survival during hyperthe...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.09.014

    authors： Ahishali B,Kaya M,Orhan N,Arican N,Ekizoglu O,Elmas I,Kucuk M,Kemikler G,Kalayci R,Gurses C

    更新日期：2010-11-20 00:00:00

  • Hyaluronic acid of high molecular weight inhibits proliferation and induces cell death in U937 macrophage cells.

    abstract：:Hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix, has regulatory influences on cells and cellular activities. To explore the effects of a high concentration (1 mg/mL) of high molecular weight HA (500-730 kD) on U937 macrophage growth dynamics, three factors that influence overall c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.02.038

    authors： Sheehan KM,DeLott LB,West RA,Bonnema JD,DeHeer DH

    更新日期：2004-11-12 00:00:00

  • Effects of VA-045, a novel apovincaminic acid derivative, on isolated blood vessels: cerebroarterial selectivity.

    abstract：:We investigated the effects of VA-045, an apovincaminic acid derivative, on isolated blood vessels. VA-045 (10(-7)-10(-5) M) and vinpocetine (10(-7)-10(-5) M) inhibited the 64 mM KCl-induced and 10(-6)M norepinephrine (NE)-induced contraction of rat aortic strips. VA-045 (10(-7)-10(-4) M) and vinpocetine (10(-7)-10(-4...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90115-j

    authors： Miyata N,Yamaura H,Tanaka M,Muramatsu M,Tsuchida K,Okuyama S,Otomo S

    更新日期：1993-01-01 00:00:00

  • The influence of aging on whole body choline release and clearance.

    abstract：:We have confirmed that hypoxia elicits a substantial rise in blood choline levels in young adult rats. An intravenous infusion of tracer quantities of [2H4]-Ch, serial measurements of blood [2H0]-Ch and [2H4]-Ch, and a simple pharmacokinetic model were used to assess the bidirectional flux of choline between the centr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00191-9

    authors： Jenden DJ,Scremin OU,Roch M,Li G

    更新日期：1996-01-01 00:00:00

  • High-fat diet affects gut nutrients transporters in hypo and hyperthyroid mice by PPAR-a independent mechanism.

    abstract：AIMS:High fat diet consumes and thyroid hormones (THs) disorders may affect nutrients metabolism, but their impact on the absorptive epithelium, the first place of nutrients access, remains unknown. Our aim was to evaluate the intestinal morphology and nutrients transporters content in mice fed standard (LFD) or high f...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.03.053

    authors： Losacco MC,de Almeida CFT,Hijo AHT,Bargi-Souza P,Gama P,Nunes MT,Goulart-Silva F

    更新日期：2018-06-01 00:00:00

  • Loperamide effects on hepatobiliary function, intestinal transit and analgesia in mice.

    abstract：:Loperamide effects on hepatobiliary function, analgesia and gut transit were studied in mice. Varying doses of the antidiarrheal drug, loperamide, were administered to mice by intracerebroventricular, intravenous, subcutaneous and intragastric routes. Gut motility was determined by intestinal transit of India ink, ana...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00609-1

    authors： Hurwitz A,Sztern MI,Looney GA,Ben-Zvi Z

    更新日期：1994-01-01 00:00:00

  • Alpha adrenergic drugs inhibit [3H]-QNB binding to muscarinic receptors of rat heart, brain and parotid gland membranes.

    abstract：:Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90436-u

    authors： Simon G,Filep J,Zelles T

    更新日期：1990-01-01 00:00:00

  • Rapid and opposite effects of cortisol and estradiol on human erythrocyte Na+,K+-ATPase activity: relationship to steroid intercalation into the cell membrane.

    abstract：:We determined whether two naturally occurring steroids, cortisol and 17beta-estradiol (E2), can rapidly modulate the activity of an important membrane protein, human erythrocyte (RBC) Na+,K+-ATPase, an enzyme that does not bind either hormone directly. We also determined the membrane binding locations for cortisol and...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00360-4

    authors： Golden GA,Mason RP,Tulenko TN,Zubenko GS,Rubin RT

    更新日期：1999-01-01 00:00:00

  • Insulin-like growth factor-1 is not mitogenic for the Walker-256 carcinosarcoma.

    abstract：:This study was designed to determine whether intravenous infusion of recombinant human insulin-like growth factor 1 (IGF-1) stimulates tumor growth. In order to determine the potential interaction between nutrition and IGF-1 administration the study was conducted in fasting rats and during continuous feeding by total ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00005-q

    authors： Wan JM,Istfan NW,Ye SL,Bistrian BR

    更新日期：1995-01-01 00:00:00

  • Effect of age on the vasorelaxation elicited by cromakalim. Role of K+ channels and cyclic GMP.

    abstract：:The objective of this study was to investigate whether age induces changes on vasodilator response induced by cromakalim, an ATP-sensitive K+ (K(ATP)) channel opener, as well as the underlying mechanism involved in this possible alteration. For this purpose, aortic segments from young (3-5 months) and old (3 years) ra...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)80003-4

    authors： Ferrer M,Tejera N,Marín J,Balfagón G

    更新日期：1998-01-01 00:00:00

  • Differential down-regulation of alpha-2 adrenergic receptor subtypes.

    abstract：:The regulation of G protein-coupled receptor expression is important in the physiology of an organism and can occur at any of the steps between gene transcription to turnover of the receptor protein itself. Agonist stimulation causes receptor desensitization, which is characterized by a rapid reduction in response to ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0024-3205(98)00091-5

    authors： Heck DA,Bylund DB

    更新日期：1998-01-01 00:00:00

  • Acetylcholine released from T cells regulates intracellular Ca2+, IL-2 secretion and T cell proliferation through nicotinic acetylcholine receptor.

    abstract：AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.12.015

    authors： Mashimo M,Iwasaki Y,Inoue S,Saito S,Kawashima K,Fujii T

    更新日期：2017-03-01 00:00:00

  • Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test.

    abstract：:We investigated the role of sensory nerves in glucose tolerance in conscious Wistar rats neonatally treated with neurotoxin capsaicin or vehicle. Intravenous glucose tolerance tests (IVGTT, 150, 300 and 450 mg in 30 min) were performed to measure glucose tolerance, and glucose, insulin and glucagon levels were measure...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.03.011

    authors： van de Wall EH,Gram DX,Strubbe JH,Scheurink AJ,Koolhaas JM

    更新日期：2005-07-29 00:00:00

  • Inhibitory guanine nucleotide regulatory protein alpha-subunits in brain of spontaneously hypertensive rats.

    abstract：:Previously we have reported a decreased GABAB receptor expression in brain of spontaneously hepertensive rats (SHR). Moreover, decreased receptor numbers were accompanied by depressed stimulation of cAMP formation. We have now quantified Gi alpha protein by immunoblotting in cerebral membranes from 11-week-old normote...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(96)00573-5

    authors： Ichida T,Takeda K,Sasaki S,Nakagawa M,Kuriyama K

    更新日期：1996-01-01 00:00:00

  • In vitro interaction of premazepam with benzodiazepine receptors in rat brain regions.

    abstract：:Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding sites on rat brain synaptosomes, with a potency intermediate to other benzodiazepines (BDZs), and Hill coefficients near 1 in different brain regions. Incubation at 37 degrees C reduced prem...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90646-5

    authors： Barone D,Colombo G,Glasser A,Luzzani F,Mennini T

    更新日期：1984-07-23 00:00:00

  • Physiological concentrations of β-hydroxybutyrate do not promote adipocyte browning.

    abstract：AIMS:Previous work has demonstrated that ketogenic diets promote white fat browning; however, the exact mechanisms underlying this phenomenom have yet to be elucidated. Recently, an in vitro study showed that supraphysiological concentrations of β-hydroxybutyrate (βHB) had a strong influence on the induction of adipocy...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116683

    authors： de Oliveira Caminhotto R,Andreotti S,Komino ACM,de Fatima Silva F,Sertié RAL,Christoffolete MA,Reis GB,Lima FB

    更新日期：2019-09-01 00:00:00

  • Myocardial infarction in the guinea pig: cellular electrophysiology.

    abstract：:The cellular electrophysiology of left ventricular preparations from guinea pig hearts was studied 1 hour, 24 hours, and 4-6 weeks after myocardial infarction produced by 6-8 single ties of the distal left coronary artery system or after sham operation. Microelectrode recordings were used to monitor cells from the end...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90343-1

    authors： Gaide MS,Cameron JS,Altman CB,Myerburg RJ,Bassett AL

    更新日期：1985-06-24 00:00:00