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Diagnostic, prognostic, and therapeutic significance of miR-139-5p in cancers.

Abstract：

:miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either promote or suppress tumor development by mediating different signaling pathways. miR-139-5p, located on chromosome 11q13.4, has been examined extensively in cancers. Studies have demonstrated that miR-139-5p might be an attractive cancer biomarker. Herein, we will review how miR-139-5p acts in cancer diagnosis, prognosis, and therapy, as well as elucidating its major target genes and associated signaling pathways.

journal_name

Life Sci

journal_title

Life sciences

authors

Khalili N,Nouri-Vaskeh M,Hasanpour Segherlou Z,Baghbanzadeh A,Halimi M,Rezaee H,Baradaran B

doi

10.1016/j.lfs.2020.117865

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

117865

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(20)30615-9

journal_volume

256

pub_type

杂志文章,评审

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