Abstract:
:Hyperketonemia has been identified as an important factor in diabetic pregnancy affecting growth and development of the offspring. In order to assess the immediate metabolic alterations in embryos caused by excess ketone bodies, we studied rat embryonic neural tissue exposed to a high concentration of beta-hydroxybutyrate in vitro. Beta-hydroxybutyrate inhibited oxygen uptake of the neural tissue of day 9 and day 10 embryos by 12.8% and 1 1.2%, but did not affect that of day 11 and day 12 tissue. In contrast, glucose utilization of the neural tissue of day 9 and day 10 embryos was not altered. However, a 30% decrease in glucose utilization was observed in the neural tissue of day 11 and day 12 embryos exposed to beta-hydroxybutyrate. Thus, beta-hydroxybutyrate induced different metabolic alterations in the embryonic neural tissue during early and late organogenesis, which suggests different modes of teratogenic action of ketone bodies in different parts of gestation.
journal_name
Life Scijournal_title
Life sciencesauthors
Yang X,Borg LA,Eriksson UJdoi
10.1016/s0024-3205(97)01110-7subject
Has Abstractpub_date
1998-01-01 00:00:00pages
293-300issue
4eissn
0024-3205issn
1879-0631pii
S0024320597011107journal_volume
62pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:AIMS:The dysregulation of circular RNAs (circRNAs) has been implicated in the progression of diabetic retinopathy (DR). This study aims to explore the role and underlying mechanism of hsa_circ_0081108 (circCOL1A2) in DR. MATERIALS AND METHODS:circCOL1A2, vascular endothelial growth factor (VEGF) and miR-29b expression...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117888
更新日期:2020-09-01 00:00:00
abstract::Muscarinic receptors on epithelial cells mediate intestinal secretion, while those in intestinal smooth muscle mediate motility. Experiments were carried out to determine whether the muscarinic receptors mediating each of these two functions in intestinal tissue might be associated with differences in the way agonist ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90444-8
更新日期:1985-05-20 00:00:00
abstract::Immunotherapy with immune checkpoint inhibitors, such as anti-PD-1 drugs, is an area in increasing development for its efficacy and advantages in the treatment of advanced metastatic melanoma. In fact, immunotherapy has been the target of several and recent studies in different types of cancer, namely in melanoma, a g...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2019.117093
更新日期:2020-01-01 00:00:00
abstract::[3H]5-HT binding sites were analyzed in membranes prepared from the rabbit caudate nucleus (CN). [3H]5-HT labeled both 5-HT1A and 5-HT1C recognition sites, defined by nanomolar affinity for 8-OH-DPAT and mesulergine respectively; however, these represented only a fraction of total specific [3H]5-HT binding. Saturation...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90033-7
更新日期:1989-01-01 00:00:00
abstract:AIMS:The renin-angiotensin system (RAS) plays a major role in cardiovascular diseases in postmenopausal women, but little is known about its importance to lower urinary tract symptoms. In this study we have used the model of ovariectomized (OVX) estrogen-deficient rats to investigate the role of RAS in functional and m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.09.008
更新日期:2013-11-19 00:00:00
abstract::Three neurodegenerative diseases, Huntington's disease (HD), Kennedy's disease (hereditary spinobulbar muscular atrophy, SBMA), and type 1 spinocerebellar ataxia (SCA-1) have been found to share a common genetic defect: an unstable region of repeated CAG trinucleotides which are thought to be translated into a polyglu...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(94)90012-4
更新日期:1994-01-01 00:00:00
abstract::Calcium entry from extracellular space to acetylcholine (ACh)-sensitive internal stores was investigated in beta-escin permeabilized bovine tracheal smooth muscle. Cyclopiazonic acid (CPA), a selective inhibitor of the sarcoplasmic reticulum (SR) calcium pump, and nifedipine, both inhibited the refilling, and inhibiti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00152-6
更新日期:1999-01-01 00:00:00
abstract::Two male adult rhesus monkeys were used and caged individually. The room was temperature-controlled having a light-dark period of 12/12 hours. The animals were rapidly immobilized and immediately anesthetized with ketamine i. m. (10 mg/kg of body weight). They were bled four times at 15, 30, 45 and 60 mins after the k...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90247-9
更新日期:1991-01-01 00:00:00
abstract:AIMS:Hypoxia-inducible factor-1α (HIF-1α) is a transcriptional regulator of cellular responses to hypoxic stress. MicroRNAs (miRNAs) play an essential role in hypoxia-mediated cellular responses. Previous studies have identified some let-7 family members as hypoxia-regulated miRNAs (HRMs). In the present study, we aime...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.01.005
更新日期:2017-02-15 00:00:00
abstract::Acute ingestion of ethanol impairs memory, an effect which might be related to ethanol-induced inhibition of vasopressin release. This was studied using tests of memory and cognitive function in 26 normal subjects before and after ethanol ingestion. Equal numbers of subjects received randomly, by double-blind intranas...
journal_title:Life sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0024-3205(85)90607-1
更新日期:1985-12-30 00:00:00
abstract::The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (DSP4) or serotonergic (5,7-DHT) lesions. Continuous administration of gepirone in non-lesioned rats for 3, 7, ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90478-t
更新日期:1991-01-01 00:00:00
abstract::Endothelin-1 (ET-1) has been proposed as one of the possible mediators of the vasoconstriction seen following ischemia and reperfusion. We investigated the effect of ischemia and reperfusion on the contractile response of canine renal and iliac arteries to the dihydropyridine-type calcium channel agonist (+/-)Bay K 86...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00267-a
更新日期:1995-01-01 00:00:00
abstract::Effects of sub-acute cocaine treatment on 3H-naloxone binding to 6 brain regions were examined in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Cocaine hydrochloride (3 mg/kg, i.v.) was given by bolus injection daily for five days. Rats were decapitated 24 hr following the final injection and crude mem...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90421-3
更新日期:1988-01-01 00:00:00
abstract:AIMS:To investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associate...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116822
更新日期:2019-10-15 00:00:00
abstract::In vitro effects of medicinal plant extracts from the pericarpium of Citrus reticulata (cv Jiao Gan) (PCRJ) on the growth and differentiation of a recently characterized murine myeloid leukemic cell clone WEHI 3B (JCS) were investigated. Extracts of PCRJ not only inhibited the proliferation of JCS cells in a dose depe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00088-4
更新日期:1996-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) and retinoid x receptor (RXR) play important roles in fatty acid metabolism. The present study examined the regulation of retinoic acid receptor (RAR alpha, beta, and gamma), RXR (alpha, beta, and gamma), PPAR, cytochrome P450 2E1 (CYP2E1), catalase, and beta-actin gen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00953-8
更新日期:1995-01-01 00:00:00
abstract:AIMS:Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in melanoma. MATERIALS AND METHODS:Expression of circ_00840...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117323
更新日期:2020-02-15 00:00:00
abstract::We have previously reported that metronidazole treatment increases human lymphocyte proliferation showing individual differences. This drug and its metabolites are imidazole compounds like histamine and cimetidine. The first is an endogenous amine that inhibits T-helper lymphocyte proliferation, and the second is a hi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00297-4
更新日期:1996-01-01 00:00:00
abstract::In a partially depolarized guinea pig papillary muscle preparation, BAY K8644 stimulated voltage-operated calcium channels, promoting slow action potentials; this effect was dose-dependent over a concentration range of 3 X 10(-7) M to 3 X 10(-6) M. Isoproterenol and histamine also induced slow action potentials by sti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90651-x
更新日期:1986-07-28 00:00:00
abstract:AIMS:The clinical efficiency of dendritic cell (DC) therapy needs to be improved. Exosomes, as membrane nano-vesicles, carry bio-macromolecules and play essential roles in intercellular crosstalk. Here, it is proposed that tumor cell-derived exosomes could function as vehicles to deliver exogenous miRNA-155 into DCs, f...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.01.005
更新日期:2019-02-15 00:00:00
abstract::Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). DHEA inhibited the growth of two stains of HeLa and WI-38 cells in culture. One of the HeLa strains, TCRC-2, was about 10x as sensitive to growth inhibition a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90557-6
更新日期:1986-04-21 00:00:00
abstract:AIMS:In myocardial ischemia-reperfusion (MI/R) injury, impaired autophagy function worsens cardiomyocyte death. AMP-activated protein kinase (AMPK) is a heterotrimeric protein that plays an important role in cardioprotection and myocardial autophagic function. AMPKα1 and α2 are localized primarily in the cytoplasm and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.04.002
更新日期:2019-05-15 00:00:00
abstract::Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants. It is also known that some convulsant and anticonvulsant drug actions are mediated by the GABA-receptor chloride-ionophore complex. Drugs acting at this complex appear to induce convu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90107-5
更新日期:1988-01-01 00:00:00
abstract::Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance. The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.08.018
更新日期:2006-03-06 00:00:00
abstract::The extended infection with Helicobacter pylori (H. pylori), one of the most frequent infectious agents in humans, may cause gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. During H. pylori infection, different kinds of inflammatory cells such as dendritic cells...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2019.116688
更新日期:2019-08-15 00:00:00
abstract::Peroxisome-proliferator activated receptor-gamma (PPARgamma) has been demonstrated to exert an inhibitory effect on cell growth in most cell types studied, but its role in colon cancer is still uncertain. The molecular mechanism between the activation of PPARgamma and its consequence is unknown. In the present report,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01510-2
更新日期:2002-04-19 00:00:00
abstract::This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90682-3
更新日期:1983-10-31 00:00:00
abstract:AIMS:Honokiol is a natural product extracted from herbal plants such as the Magnolia species which have been shown to exhibit anti-tumor and anti-metastatic properties. However, the effects of honokiol on thyroid cancers are largely unknown. MATERIALS AND METHODS:To determine whether honokiol might be useful for the t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.06.002
更新日期:2018-08-15 00:00:00
abstract::The present study was planned to determine the mechanisms involved in the renal vasodilation caused by insulin. Changes in flow caused by the intravenous infusion of 0.004 IU/kg/min of insulin at constant heart rate, aortic blood pressure, left ventricular contractility and blood levels of glucose and potassium in the...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01257-7
更新日期:2001-08-24 00:00:00
abstract::Peptides derived from tryptic hydrolysate of jumbo squid (Dosidicus gigas) skin gelatin were assessed for their antioxidant properties in different in vitro assay systems. The hydrolysate itself exhibited a strong lipid peroxidation inhibition and it was much higher than that of natural antioxidant, alpha-tocopherol. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.03.016
更新日期:2005-09-09 00:00:00