Abstract:
:Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). DHEA inhibited the growth of two stains of HeLa and WI-38 cells in culture. One of the HeLa strains, TCRC-2, was about 10x as sensitive to growth inhibition as the two other cell lines. The G6PDH activity in cell extracts of HeLa TCRC-2 was also much more sensitive to DHEA inhibition than the G6PDH activities of the other cell lines. The addition of a combination of four deoxyribonucleosides and four ribonucleosides to the culture medium overcame the DHEA-induced growth inhibition in the HeLa TCRC-2 line.
journal_name
Life Scijournal_title
Life sciencesauthors
Dworkin CR,Gorman SD,Pashko LL,Cristofalo VJ,Schwartz AGdoi
10.1016/0024-3205(86)90557-6subject
Has Abstractpub_date
1986-04-21 00:00:00pages
1451-7issue
16eissn
0024-3205issn
1879-0631pii
0024-3205(86)90557-6journal_volume
38pub_type
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