Abstract:
:Hyperlipidemia and the glomerular accumulation of atherogenic lipoproteins (low density lipoprotein, LDL; and its oxidatively-modified variants, ox-LDL) are commonly associated with the development of glomerular mesangial proliferative diseases. However, cellular signaling mechanisms by which atherogenic lipoproteins stimulate mesangial cell proliferation are poorly defined. In this study, we examined the effect of atherogenic lipoproteins on the activation of mesangial cell epidermal growth factor (EGF) receptor, mitogen activated protein kinase (MAP kinase), Ras, and mesangial cell proliferation. Stimulation of mesangial cells with LDL, and with greater activity, ox-LDL, markedly induced the transactivation of EGF receptor within 5 min of stimulation; the effect persisted up to at least 60 min LDL, and with a greater degree, ox-LDL, increased the activation of Ras, MAP kinase, and mesangial cell proliferation. Inhibition of EGF receptor kinase activity and/or MAP kinase activation blocked both LDL- and ox-LDL-induced mesangial cell proliferation. We suggest that the accumulation of LDL and more potently its oxidized forms within the glomerulus, through the transactivation of EGF receptor, stimulate down-stream Ras-MAP kinase signaling cascade leading to mesangial cell proliferation. Regulation of glomerular accumulation of atherogenic lipoproteins and/or EGF receptor signaling may provide protective environment against mesangial hypercellularity seen in glomerular diseases.
journal_name
Life Scijournal_title
Life sciencesauthors
Kamanna VS,Bassa BV,Ganji SHdoi
10.1016/j.lfs.2008.08.010subject
Has Abstractpub_date
2008-10-24 00:00:00pages
595-601issue
17-18eissn
0024-3205issn
1879-0631pii
S0024-3205(08)00341-Xjournal_volume
83pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The effect of wortmannin (WT), an inhibitor of myosin light chain kinase (MLCK) as well as PI3-kinase, on catecholamine (CA) secretion in the perfused rat adrenal medulla was studied. After a 35-min application of 10 microM WT, secretory response to repetitive stimulation with 30 mM extracellular K+ was reduced to 30%...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00842-0
更新日期:2000-10-13 00:00:00
abstract::The role of serotonin (5-HT) in the regulation of steroidogenesis in the ovary via 5-HT2 receptor was studied in normal cycling rats and their preovulatory follicles. Oral administration of ketanserin (KET), a selective 5-HT2 antagonist, at 10 mg/kg BW at 1100h on the day of proestrus resulted in a marked decrease in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90713-d
更新日期:1993-01-01 00:00:00
abstract:AIMS:Oncogenic RET/PTC1 chromosomal rearrangements are hallmarks of thyroid papillary carcinoma. The resulting protein, mainly through tyrosine 451, is responsible for the activation of pathways controlling cell survival, including the PI3K/Akt/mTOR cascade. Vanadium compounds were shown to have anti-neoplastic potenti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.07.004
更新日期:2011-09-12 00:00:00
abstract:AIMS:Mancozeb is a dithiocarbamate fungicide known to be genotoxic and induces tumors in rodents at various sites. There is no report in the literature about its genotoxicity in humans. Here, we investigated the association between mancozeb exposure and induction of genotoxic and proapoptotic changes in cultured human ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.12.013
更新日期:2012-06-06 00:00:00
abstract:AIMS:This study was aimed to investigate the effect of Lycium barbarum polysaccharides (LBP) on renal function and inflammatory reaction in rabbits with diabetic nephropathy. MAIN METHODS:Diabetes was induced by injecting alloxan (ALX). Japanese male white rabbits were randomly assigned into 5 groups: normal control g...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.05.045
更新日期:2016-07-15 00:00:00
abstract:AIMS:Ovarian cancer (OC) is the most lethal gynecologic malignant tumors all over the world. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been reported as an important regulator in multiple tumors. However, the functions of HOTAIRM1 in OC and its possible molecular mechanisms remain unclear. MAIN METHODS:qRT-...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117296
更新日期:2020-02-15 00:00:00
abstract::When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, whi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90563-5
更新日期:1983-01-01 00:00:00
abstract:AIMS:To investigate the roles of neutrophil alkaline phosphatase (NAP) in the migration, reactive oxygen species (ROS) generation and apoptosis of neutrophils. MAIN METHODS:NAP was overexpressed in neutrophil-like differentiated HL-60 cells via transfecting coding sequence of NAP by lentivirus. NAP overexpression in H...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.005
更新日期:2016-07-15 00:00:00
abstract:AIMS:The clinical efficiency of dendritic cell (DC) therapy needs to be improved. Exosomes, as membrane nano-vesicles, carry bio-macromolecules and play essential roles in intercellular crosstalk. Here, it is proposed that tumor cell-derived exosomes could function as vehicles to deliver exogenous miRNA-155 into DCs, f...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.01.005
更新日期:2019-02-15 00:00:00
abstract:AIMS:The present study aimed to investigate the mechanism of bone repair mediated by recombination BMP-2 (rhBMP-2)/recombination CXC chemokine ligand-13 (rhCXCL13)-loaded hollow hydroxyapatite (HA) microspheres/chitosan (CS) composite. MATERIALS AND METHODS:Firstly, the biological activity of rhBMP-2 and rhCXCL13 rele...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116743
更新日期:2019-10-01 00:00:00
abstract::The ileal Na+/bile acid cotransporter (IBAT) maintains the reabsorption of bile acids from the intestine in the enterohepatic circulation of bile acids. In the present study, we showed that S-8921 could dose-dependently inhibit the uptake of [3H] taurocholate in the COS7 cell line which constitutively expresses hamste...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00242-7
更新日期:1997-01-01 00:00:00
abstract:AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117424
更新日期:2020-06-15 00:00:00
abstract::Epidemiological studies have shown that cigarette smoke, an oxidant agent, is a risk factor for the development of diabetic nephropathy (DN), in which pathogenesis transforming growth factor beta(1) (TGFbeta(1)) plays a key role. In our experimental model we exposed mesangial cell cultures to cigarette smoke concentra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.12.026
更新日期:2004-06-18 00:00:00
abstract::The objective of this study was to understand the mechanism of action of nitric oxide (NO) in the heart by determining whether nitric oxide (NO) released from sodium nitroprusside (SNP) induces p38 mitogen activated protein kinase (p38 MAPK) phosphorylation and whether this is mediated through a cyclic GMP (cGMP)/prot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.06.022
更新日期:2007-08-02 00:00:00
abstract::We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00363-3
更新日期:1996-01-01 00:00:00
abstract::Sodium-dependent transport of D-glucose has been reported only in epithelial cells of small intestine and kidney, and well-differentiated tumors thereof. We observed a two-fold decrease (p < 0.05) in the intracellular distribution volume (Vic, defined as steady-state intracellular uptake divided by extracellular conce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00114-2
更新日期:1996-01-01 00:00:00
abstract::Prolonged use of glucocorticoids is associated with decreased bone formation, increased resorption and osteonecrosis, through direct and indirect effects on the activity and viability of bone effector cells, osteoblasts and osteoclasts, and osteocytes. This study has investigated molecular pathways implicated in Dexam...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.04.048
更新日期:2004-10-29 00:00:00
abstract::Puromycin is an experimental anti-tumor antibiotic acting through inhibition of protein synthesis. Because of its untoward side effects (as inner ear and renal lesions) the antibiotic was not approved for clinical trials. The mechanism underlying the organ specificity of the side effect is not understood. In view of t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.10.070
更新日期:2005-06-17 00:00:00
abstract::In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00328-2
更新日期:1998-01-01 00:00:00
abstract::Exposure of rats to an acute, uncontrollable stressor can increase brain norepinephrine (NE) turnover and decrease locomotor and exploratory behavior. We examined the ability of exogenous tyrosine, NE's amino acid precursor, to protect rats from developing these neurochemical and behavioral changes when stressed. Anim...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90209-1
更新日期:1984-06-04 00:00:00
abstract:AIMS:Ischemia-reperfusion injury is one of the most common cardiac disorders leading to irreversible heart damage. Many underlying mechanisms seem to be involved, among which mitochondrial dysfunction. Since physical training has a beneficial effect on mitochondrial dynamics (fusion and fission), it may have a cardiopr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.10.035
更新日期:2018-11-15 00:00:00
abstract::Immunotherapy with immune checkpoint inhibitors, such as anti-PD-1 drugs, is an area in increasing development for its efficacy and advantages in the treatment of advanced metastatic melanoma. In fact, immunotherapy has been the target of several and recent studies in different types of cancer, namely in melanoma, a g...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2019.117093
更新日期:2020-01-01 00:00:00
abstract::Abnormal activation of the beta-catenin signaling pathway can cause various types of cancer. Activation of Wnt pathway leads to stabilization of the beta-catenin protein, which results in its translocation to the nucleus and the formation of complexes with lymphoid enhancer factor-1 (LEF-1) and other T-cell factor (TC...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.02.009
更新日期:2005-07-29 00:00:00
abstract::Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118847
更新日期:2021-02-01 00:00:00
abstract::Human uridinediphosphate-glucuronosyltransferase 1A1 (UGT1A1) was expressed in Salmonella typhimurium TA1535 cells by transfection of the cells with plasmids carrying the UGT1A1 cDNA. UGT1A1 cDNA was isolated by a polymerase chain reaction from human liver total RNA and was inserted into the pSE420 plasmid, linked to ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00521-x
更新日期:2000-04-07 00:00:00
abstract::Endothelin-1 (ET-1) is produced from its precursor, big endothelin-1 (BigET-1), by a putative endothelin-converting enzyme (ECE), but it is not known whether the enzyme is present in the brain. This study was conducted to examine the central hemodynamic effects of BigET-1 and to indirectly determine the presence of an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90491-s
更新日期:1991-01-01 00:00:00
abstract::The antinociceptive effect of the benzomorphan class of opioid analgesics have been difficult to measure utilizing some of the standard animal pain models. This may be due, in part, to the sedative and/or motor effects associated with these drugs. In addition, it has been proposed that the major site of action for dru...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90270-5
更新日期:1986-01-06 00:00:00
abstract:AIMS:The purposes of this study were to determine whether Cervi Pantotrichum Cornu (CPC) has osteogenic activities in human osteoblastic MG-63 cells and to investigate the underlying molecular mechanism. MAIN METHODS:The effects of CPC on alkaline phosphatase activity, collagen synthesis, and calcium deposits were mea...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.11.002
更新日期:2014-01-14 00:00:00
abstract::The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90331-7
更新日期:1989-01-01 00:00:00
abstract::The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is rapidly metabolized to a 1-methyl-4-phenylpyridinium species (MPP+) in the squirrel monkey. After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the hi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90060-8
更新日期:1985-01-21 00:00:00