Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment.

abstract：:Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphe...

journal_title：Life sciences

authors： Kashihara K,Sakai K,Marui K,Shohmori T

更新日期：1998-01-01 00:00:00

abstract：AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...

journal_title：Life sciences

authors： Mashimo M,Iwasaki Y,Inoue S,Saito S,Kawashima K,Fujii T

更新日期：2017-03-01 00:00:00

abstract：:The loss of gamma-aminobutyric acid (GABA)-ergic medium spiny neurons (MSNs) in the striatum is the hallmark of Huntington disease (HD), an incurable neurodegenerative disorder characterized by progressive motor, psychiatric, and cognitive symptoms. Transplantation of MSNs or their precursors represents a promising tr...

journal_title：Life sciences

authors： Golas MM

更新日期：2018-09-15 00:00:00

abstract：AIMS:Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to t...

journal_title：Life sciences

authors： Tong G,Sun Z,Wei X,Gu C,Kaye AD,Wang Y,Li J,Zhang Q,Guo H,Yu S,Yi D,Pei J

更新日期：2011-01-03 00:00:00

abstract：:Repeated intermittent administration of amphetamine in mice caused reverse tolerance to 5-hydroxy-L-tryptophan (5-HTP)-induced head twitch, as well as to amphetamine-induced stereotypy. The repeated administration of 5-HTP alone also resulted in reverse tolerance in the head-twitch test. Daily pretreatment with halope...

journal_title：Life sciences

authors： Karler R,Calder LD,Turkanis SA

更新日期：1990-01-01 00:00:00

abstract：:Semicarbazones induce an anticonvulsant effect in different experimental models. As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated. BS (10, 25 or 50 mg/kg, i.p.) markedly inhibited the sec...

journal_title：Life sciences

authors： Rocha LT,Costa KA,Oliveira AC,Nascimento EB Jr,Bertollo CM,Araújo F,Teixeira LR,Andrade SP,Beraldo H,Coelho MM

更新日期：2006-06-27 00:00:00

abstract：:Specific 125I-CCK receptor binding was significantly increased in brain tissue taken from guinea pig or mouse following chronic (2-3 week) daily administration of haloperidol (2-3 mg/kg/day). Scatchard analysis indicated the increase in CCK binding was due to an increased receptor number (B max) with no change in affi...

journal_title：Life sciences

authors： Chang RS,Lotti VJ,Martin GE,Chen TB

更新日期：1983-02-21 00:00:00

abstract：:Differences in prevalence and mortality from coronary artery disease (CAD) were observed among the different Israeli ethnic groups. The incidence of CAD in Israel is highest among Ashkenazi Jews and is much lower among Yemenite Jews. In this present study, we selected 15 single nucleotide polymorphisms (SNPs) from 14 ...

journal_title：Life sciences

authors： Nakai K,Habano W,Nakai K,Fukushima N,Fujita T,Gurwitz D

更新日期：2004-07-09 00:00:00

abstract：AIMS:Perinatal hypoxic-ischemic insult has acute and long term deleterious effects on many organs including heart. Although tumor necrosis factor alpha (TNF-α) has been reported to increase soon after hypoxia, the inhibition of this mediator has not been documented. The aim of this study was to investigate the effects ...

journal_title：Life sciences

authors： Büyükakilli B,Atici A,Özkan A,Balli E,Güneş S,Turhan AH,Hallioglu O,Kanik A

更新日期：2012-06-06 00:00:00

abstract：:The purpose of this study was to investigate the effect of T3 on amino acid accumulation and on the membrane potential of Sertoli cells of immature rat testes. Testes of pre-pubertal and pubertal rats were pre-incubated (30 min) in Krebs-Ringer bicarbonate buffer and incubated in the presence of [14C]methylaminoisobut...

journal_title：Life sciences

authors： Silva FR,Leite LD,Barreto KP,D'Agostini C,Zamoner A

更新日期：2001-07-13 00:00:00

abstract：:P75(NTR) is a common neurotrophin receptor which binds all neurotrophins with similar affinities and has been shown to be capable of mediating programmed cell death. In this study, we investigated effects of the antipsychotic drugs (APDs) haloperidol, clozapine, quetiapine, and risperidone on p75(NTR) mRNA levels in P...

journal_title：Life sciences

authors： Bai O,Xu H,Li XM

更新日期：2006-07-04 00:00:00

abstract：:In this study, we have focused our investigation of the facts whether co-administration of a NMDA antagonist dextromethorphan (DM) with morphine during pregnancy and throughout lactation could prevent the adverse effects associated with chronic morphine administration in rat offspring. Adult female Sprague-Dawley rats...

journal_title：Life sciences

authors： Tao PL,Yeh GC,Su CH,Wu YH

更新日期：2001-10-05 00:00:00

abstract：:The role of FSH in inducing folliculogenesis is well established. Recently, the availability of pure FSH has led to a reevaluation of its role in the process of ovulation. Previously, these functions have been examined separately, usually with pregnant mares' serum gonadotropin (PMSG) followed by FSH for ovulation or ...

journal_title：Life sciences

authors： Rice VC,Zusmanis K,Malter H,Mitchell-Leef D

更新日期：1993-01-01 00:00:00

abstract：:The infection epidemic event of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was formally declared a pandemic by World Health Organization on March 11th, 2020. Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a new type of coronavirus, which has high contagion and mainly causes respira...

journal_title：Life sciences

authors： Peng W,Wu H,Tan Y,Li M,Yang D,Li S

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...

journal_title：Life sciences

authors： Husain SS,Szabo IL,Pai R,Soreghan B,Jones MK,Tarnawski AS

更新日期：2001-11-09 00:00:00

abstract：AIMS:We elucidated the therapeutic potential of human umbilical vein endothelial cells (HUVECs) for ameliorating progressive heart failure in a myocardial infarction (MI) rat model. MAIN METHODS:MI was induced by ligation of left anterior descending artery, and HUVEC was transplanted 1week after MI. Cardiac function w...

journal_title：Life sciences

authors： Kwon JS,Kim YS,Cho AS,Cho HH,Kim JS,Hong MH,Jeong HY,Kang WS,Hwang KK,Bae JW,Jeong MH,Cho MC,Ahn Y

更新日期：2014-04-17 00:00:00

abstract：:The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...

journal_title：Life sciences

authors： Uchida S,Kato Y,Hirano K,Kagawa Y,Yamada S

更新日期：2007-04-03 00:00:00

abstract：:Antroduodenal myoelectric activity was recorded in conscious sheep by electrodes chronically implanted in the muscular wall. Furthermore, plasma immunoreactive (i.r.) motilin, somatostatin and bombesin concentrations were determined by RIA. The intravenous infusion of somatostatin (20 ng/kg/min), bombesin (10 ng/kg/mi...

journal_title：Life sciences

authors： Plaza MA,Arruebo MP,Murillo MD

更新日期：1996-01-01 00:00:00

abstract：:When s-triazolo[3,4-a]phthalazine (Tri-P) was orally administered in rats, a more lipophilic metabolite M-1 than the parent compound was isolated from the urine. The metabolite M-1 was identified as 7-methylthio Tri-P by means of high resolution MS and two-dimensional NMR spectrometry. Furthermore, the 7-methylthio co...

journal_title：Life sciences

authors： Imamura Y,Noda A,Imamura T,Ono Y,Okawara T,Noda H

更新日期：2003-11-21 00:00:00

abstract：:Although nitrosation plays an important role in initiation of carcinogenesis, the reactive nitrogen oxygen species (RNOS) mediating this reaction by multiple pathways have not been determined. The heterocyclic amine carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was used as a target to investigate RNOS and pa...

journal_title：Life sciences

authors： Lakshmi VM,Zenser TV

更新日期：2007-01-23 00:00:00

abstract：AIMS:TsTX-I scorpion toxin, also known as γ-toxin, is a β-toxin which binds to site 4 of the sodium channel, shifting its activation potential. There are few studies about its pharmacological action in the central nervous system. The objective of this work was to determine the electroencephalographic, behavioral and hi...

journal_title：Life sciences

authors： Teixeira VF,Conceição IM,Lebrun I,Nencioni AL,Coronado Dorce VA

更新日期：2010-10-09 00:00:00

abstract：:The microscopic localization of angiotensin II receptors in the rat brainstem has been accomplished utilizing in vitro receptor autoradiographic techniques. These receptors are highly localized to discrete nuclear regions of the brainstem. Significant densities of autoradiographic grains, indicating the presence of sp...

journal_title：Life sciences

authors： Gehlert DR,Speth RC,Healy DP,Wamsley JK

更新日期：1984-04-16 00:00:00

abstract：:Obesity leads to various changes in the body. Among them, the existing inflammatory process may lead to an increase in the production of reactive oxygen species (ROS) and cause oxidative stress. Oxidative stress, in turn, can trigger mitochondrial changes, which is called mitochondrial dysfunction. Moreover, excess nu...

journal_title：Life sciences

authors： de Mello AH,Costa AB,Engel JDG,Rezin GT

更新日期：2018-01-01 00:00:00

abstract：AIMS:Endothelin-1 (ET-1) and endothelin-2 (ET-2; Trp(6)Leu(7)ET-1) are expressed by different cell types, but are considered to display identical pharmacological properties on endothelin receptors. We studied agonist-dependent aspects of endothelin(A) (ET(A))-receptor function and the importance of amino acids 6 and 7 ...

journal_title：Life sciences

authors： Compeer MG,Suylen DP,Hackeng TM,De Mey JG

更新日期：2012-10-15 00:00:00

abstract：:We investigated the effects of genistein and genistin on proliferation and apoptosis of human ovarian SK-OV-3 cells and explored the mechanism for these effects. SK-OV-3 cells were treated with genistein and genistin at various concentrations (ranging from 1 to 100 muM) either alone or in combination for 24 and 48 h. ...

journal_title：Life sciences

authors： Choi EJ,Kim T,Lee MS

更新日期：2007-03-20 00:00:00

abstract：:The relative potencies of the in vivo vasodilating effect on the arterioles of the hamster cheek pouch of morphine and beta-endorphin decreased significantly after chronic morphine injection, indicating the existence of tolerance to morphine and cross tolerance between morphine and beta-endorphin. The apparent pA2 val...

journal_title：Life sciences

authors： Koo A,Wong TM

更新日期：1983-01-31 00:00:00

abstract：:Nitric oxide (NO) is a highly reactive free radical that is involved in a variety of different biological process. In recent reports, the putative role of NO in the neuropathogenesis of brain inflammation has been demonstrated. And then the relation between neuronal NO and convulsive seizures induced by virus has been...

journal_title：Life sciences

authors： Kawashima H,Inage Y,Ogihara M,Kashiwagi Y,Takekuma K,Hoshika A,Mori T,Watanabe Y

更新日期：2004-01-30 00:00:00

abstract：:When HeLa cells were incubated with tritiated dexamethasone mesylate at 2 degrees C, sodium dodecyl sulfate-polyacrylamide gel electrophoresis of cytosolic and nuclear extracts revealed the presence of two monomeric receptor complex forms with estimated molecular masses of about 98 and 87 kDa. If cells were subjected ...

journal_title：Life sciences

authors： Rossini GP,Malaguti C

更新日期：1992-01-01 00:00:00

abstract：:The vascular endothelium is recognized as a barrier between blood and blood vessel wall. The abnormality of vascular endothelium is critical for atherosclerosis, hypertension and diabetes. Oxidative stress, inflammation, obesity, hyperlipidemia and insulin resistance are major contributors to endothelial dysfunction i...

journal_title：Life sciences

authors： Sun HJ,Hou B,Wang X,Zhu XX,Li KX,Qiu LY

更新日期：2016-12-15 00:00:00

abstract：:Normal mammary gland growth and reproduction were examined in C3H/HeMei mice given caffeine as drinking water (500 mg/l tap water) after weaning on day 20 of age. Caffeine ingestion had little effects on any of the day of vaginal opening, body growth, pattern of estrous cycles, mammary gland growth and reproduction ex...

journal_title：Life sciences

authors： Nagasawa H,Sakurai N

更新日期：1986-07-28 00:00:00