Endothelial dysfunction and cardiometabolic diseases: Role of long non-coding RNAs.

abstract：:The potential role of exercise in preventing the age-related spontaneous peripheral neuropathy has not been studied. We examined the effects of long-term aerobic exercise training on lipid peroxidation, Schwann cell (SC) apoptosis and ultrastructural changes in the sciatic nerve of rats during aging. Three groups of 1...

journal_title：Life sciences

authors： Shokouhi G,Tubbs RS,Shoja MM,Roshangar L,Mesgari M,Ghorbanihaghjo A,Ahmadi N,Sheikhzadeh F,Rad JS

更新日期：2008-04-09 00:00:00

abstract：AIMS:To potentiate the well-documented tumor protecting ability of paullones, literatures demand for rational modifications in paullone ring structure and exploration of a precise mechanism underlying their antitumor effects. Thus, recently we synthesized novel paullone-like scaffold, 5H-benzo [2, 3][1,4]oxazepino[5,6-...

journal_title：Life sciences

authors： Singh AK,Bhadauria AS,Kumar U,Raj V,Maurya V,Kumar D,Maity B,Prakash A,De A,Samanta A,Saha S

更新日期：2018-05-15 00:00:00

abstract：:Melanin in the skin determines the skin color, and decreased melanin causes many hypopigmentation disorders and increased damage to skin by ultraviolet B (UVB) light irradiation. Here, we stimulate melanogenesis in B16F10 melanoma cells by using specific frequencies of ELF-EMFs. In this study, we focus on the melanoge...

journal_title：Life sciences

authors： Kim YM,Cho SE,Seo YK

更新日期：2016-10-01 00:00:00

abstract：:The optical isomers of apomorphine (APO) and N-propylnorapomorphine (NPA) were interacted with three biochemical indices of dopamine (DA) receptors in extrapyramidal and limbic preparations of rat brain tissue. There were consistent isomeric preferences for the R(-) configuration of both DA analogs in stimulating aden...

journal_title：Life sciences

authors： Kula NS,Baldessarini RJ,Bromley S,Neumeyer JL

更新日期：1985-09-16 00:00:00

abstract：:The distribution pattern of ascorbic acid in the endocrine organs and/or tissues was investigated during various sexual states of female rats to demonstrate a correlation between ascorbic acid concentration and sex hormone activity. The concentration of ascorbic acid was estimated in the plasma, liver, pancreas, thyro...

journal_title：Life sciences

authors： Das PC,Das KP,Bagchi K,Dey CD

更新日期：1993-01-01 00:00:00

abstract：:Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low...

journal_title：Life sciences

authors： Geetha RK,Vasudevan DM

更新日期：2004-11-19 00:00:00

abstract：AIMS:To investigate whether hypoxia-inducible factor (HIF) 1alpha and cyclosporin A (CsA) can regulate MICA/B expression and affect NK cytotoxicity during ischemia/reperfusion (I/R) injury. MAIN METHODS:We generated an HIF-1alphaDeltaODD-expressing adenovirus which can functionally and steadily express HIF-1alpha duri...

journal_title：Life sciences

authors： Wei L,Lu J,Feng L,Long D,Shan J,Li S,Li Y

更新日期：2010-07-17 00:00:00

abstract：AIMS:DNA methylation and hydroxymethylation are significantly related to the occurrence and development of coronary heart disease (CHD) and atherosclerosis (AS). 5-Methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) are used to assess DNA methylation and hydroxymethylation levels, respectively. However, 5-mC and ...

journal_title：Life sciences

authors： Jiang D,Sun M,You L,Lu K,Gao L,Hu C,Wu S,Chang G,Tao H,Zhang D

更新日期：2019-05-01 00:00:00

abstract：:An in vivo antisense strategy was used to examine the involvement of G-protein subunits in supraspinal (intracerebroventricular; i.c.v.) alpha2-adrenoceptor-mediated antinociception. Mice that were injected with 33-mer antisense oligodeoxyribonucleotides (6 nmol) or vehicle were tested (tail-flick) with an agonist (cl...

journal_title：Life sciences

authors： Raffa RB,Connelly CD,Chambers JR,Stone DJ

更新日期：1996-01-01 00:00:00

abstract：AIMS:To investigate the effects of high doses of pentazocine on antinociception induced by a high dose of morphine and the role of the kappa-opioid receptors (KORs) in these effects in mice. MAIN METHODS:Sixty-six C57BL/6J mice were pretreated with a KOR antagonist, nor-binaltorphimine (nor-BNI) (10mg·kg(-1)), or a no...

journal_title：Life sciences

authors： Shu H,Wang Z,Ye F,Li Q,Dou Y,Lin Y,Huang W,Xiao X

更新日期：2015-06-01 00:00:00

abstract：:The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.p./day, re...

journal_title：Life sciences

authors： Wenger T,Fragkakis G,Giannikou P,Probonas K,Yiannikakis N

更新日期：1997-01-01 00:00:00

abstract：:In order to explore the effect of neonatal androgen administration on oocyte quality, ovulation induction and in vitro fertilization (IVF) were performed in androgen-sterilized mice. Androgen sterilized mice were produced by the subcutaneous injection of testosterone propionate (TP) at 5 days of age and ovulation indu...

journal_title：Life sciences

authors： Kamijo T,Mizunuma H,Yamada K,Ibuki Y

更新日期：1994-01-01 00:00:00

abstract：:The present study was planned to determine the mechanisms involved in the renal vasodilation caused by insulin. Changes in flow caused by the intravenous infusion of 0.004 IU/kg/min of insulin at constant heart rate, aortic blood pressure, left ventricular contractility and blood levels of glucose and potassium in the...

journal_title：Life sciences

authors： Molinari C,Battaglia A,Bona G,Grossini E,Mary DA,Ruggeri P,Stoker JB,Vacca G

更新日期：2001-08-24 00:00:00

abstract：:We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...

journal_title：Life sciences

authors： Bousquet P,Feldman J

更新日期：1987-03-16 00:00:00

abstract：:Recent studies suggest lipopolysaccharide (LPS) mediated cell death as underlying mechanism of hyporesponsiveness and dysfunction of macrophages in the late phase of septic shock. In the present study LPS (0.001 - 30 microg/ml) caused a concentration-dependent toxicity in the macrophage cell line (J774.1A) within 24 h...

journal_title：Life sciences

authors： Abate A,Schröder H

更新日期：1998-01-01 00:00:00

abstract：:We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related pept...

journal_title：Life sciences

authors： McMillen IC,Jenkin G,Haji-Baba AS,Browne CA,Thorburn GD

更新日期：1989-01-01 00:00:00

abstract：:Doxorubicin and daunorubicin, the anthracycline antitumor agents, were evaluated for their in vitro and in vivo effect on phosphodiesterase (PDE) activity in mouse tissues. Doxorubicin at a concentration of 10(-4)M inhibited cardiac c-AMP (adenosine 3',5', monophosphate) PDE activity 50% of the control whereas in lung...

journal_title：Life sciences

authors： Law J,Fumagalli A,Schein PS,Rahman A

更新日期：1985-02-11 00:00:00

abstract：:Patients with neurogenic orthostatic hypotension due to multiple system atrophy (MSA) or pure autonomic failure (PAF) excrete lower amounts of homovanillic acid (HVA) than do normal subjects. There is a highly significant correlation between the rates of excretion of HVA and norepinephrine metabolites. The regression ...

journal_title：Life sciences

authors： Kopin IJ,Oliver JA,Polinsky RJ

更新日期：1988-01-01 00:00:00

abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

journal_title：Life sciences

authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

更新日期：2020-07-15 00:00:00

abstract：:Sustained levels of leucine comparable to those of human Maple Syrup Urine Disease (MSUD) were achieved in blood and brain of rats by subcutaneous leucine administration twice a day from the 6th to the 28th day of life. Control rats were treated with saline in the same volumes. Behavioral studies using aversive and no...

journal_title：Life sciences

authors： Mello CF,Feksa L,Brusque AM,Wannmacher CM,Wajner M

更新日期：1999-01-01 00:00:00

abstract：:Muscarinic receptors on epithelial cells mediate intestinal secretion, while those in intestinal smooth muscle mediate motility. Experiments were carried out to determine whether the muscarinic receptors mediating each of these two functions in intestinal tissue might be associated with differences in the way agonist ...

journal_title：Life sciences

authors： Tien XY,Wahawisan R,Wallace LJ,Gaginella TS

更新日期：1985-05-20 00:00:00

abstract：:Ro41-0960 is a potent, fluorine containing COMT inhibitor which has be en reported to cross the blood brain barrier and to inhibit COMT in the brain. It is structurally similar to Ro40-7592 which is currently undergoing clinical trials in Parkinson's disease. Positron emission tomographic (PET) studies in baboon using...

journal_title：Life sciences

authors： Ding YS,Gatley SJ,Fowler JS,Chen R,Volkow ND,Logan J,Shea CE,Sugano Y,Koomen J

更新日期：1996-01-01 00:00:00

abstract：:We evaluated whether fish oil or vitamin E administration affected ethanol-induced changes in membrane ATPases. Male Wistar rats (225-250 g) were fed, through a gastric tube a liquid diet containing fish oil (25% of calories) and ethanol for one month. Another group of animals was given supplemental vitamin E (300 u/k...

journal_title：Life sciences

authors： Nanji AA,Sadrzadeh SM

更新日期：1994-01-01 00:00:00

abstract：:P-glycoprotein (P-gp) is found to play a very significant role in intestinal and biliary transport of irinotecan and its active metabolite, SN-38. This makes P-gp inhibition a logical strategy for improving irinotecan's oral efficacy and reducing its toxicity. The objective of the present study was to identify the mos...

journal_title：Life sciences

authors： Bansal T,Awasthi A,Jaggi M,Khar RK,Talegaonkar S

更新日期：2008-08-15 00:00:00

abstract：:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how auto...

journal_title：Life sciences

authors： Raj S,Chandel V,Kumar A,Kesari KK,Asthana S,Ruokolainen J,Kamal MA,Kumar D

更新日期：2020-10-15 00:00:00

abstract：:To characterize the pharmacokinetics of protein-free granisetron in blood and brain we implanted microdialysis probes into the jugular vein and cerebral frontal cortex of the rat. Granisetron (3 or 6 mg/kg, i.v., n=6) was then administered, and microdialysates from blood and brain were collected from both sites and as...

journal_title：Life sciences

authors： Huang CT,Chen CF,Tsai TH

更新日期：1999-01-01 00:00:00

abstract：AIMS:it has been suggested that Chromium (Cr), one of the essential minerals, can be beneficial to type 2 diabetic patients because it lowers blood glucose levels by improving various steps in insulin action. A few studies reported that Cr might also have some beneficial effects in people with type 1 diabetes mellitus ...

journal_title：Life sciences

authors： Kwon MJ,Chung HS,Yoon CS,Ko JH,Jun HJ,Kim TK,Lee SH,Ko KS,Rhee BD,Kim MK,Park JH

更新日期：2010-09-25 00:00:00

abstract：:Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...

journal_title：Life sciences

authors： Eshleman A,Dunigan C,Shamoo A,Eldefrawi M

更新日期：1995-01-01 00:00:00

abstract：:The present study was undertaken to examine whether there was a time-dependent change in the toxic effects of amikacin, an aminoglycoside, on renal functions. Male Wistar rats were maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Amikacin (1.2 g/kg) was injected intraperitoneally to a...

journal_title：Life sciences

authors： Fujimura A,Sudoh T,Ebihara A

更新日期：1994-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) modulates various events through several different pathways. Many tumor cells are resistant to this cytokine. Pretreatment of these cells with actinomycin D enhances TNF-alpha-induced apoptosis. In the present study, we investigated the mechanism of this enhancement and whether ...

journal_title：Life sciences

authors： Nishida S,Yoshioka S,Kinoshita-Kimoto S,Kotani M,Tsubaki M,Fujii Y,Tomura TT,Irimajiri K

更新日期：2003-12-26 00:00:00