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Effect of gamma 3 or gamma 2 melanocyte stimulating hormone on steroidogenesis in the fetal sheep during late gestation.

Abstract：

:We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related peptides in the control of fetal adrenal steroidogenesis and found no significant change in fetal plasma cortisol or pregnenolone concentrations during a 60-72 h infusion of saline, gamma 2 MSH or gamma 3 MSH in sheep between 130 and 135 days gestation. Therefore although we have demonstrated the presence of gamma MSH related peptides in fetal sheep plasma during late gestation we have failed to demonstrate a role for gamma 3 or gamma 2 MSH in the changes in fetal steroid concentrations which occur prepartum.

journal_name

Life Sci

journal_title

Life sciences

authors

McMillen IC,Jenkin G,Haji-Baba AS,Browne CA,Thorburn GD

doi

10.1016/0024-3205(89)90618-8

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

563-9

issue

8

eissn

0024-3205

issn

1879-0631

pii

0024-3205(89)90618-8

journal_volume

44

pub_type

杂志文章

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