Abstract:
:In our previous paper (Biochem. Biophys. Res. Commun. 141, 20-26 (1986) we reported the isolation of a 34000-dalton protein (p34K) which binds to calmodulin and F-actin from chicken gizzard smooth muscle. We examined the distribution of the immunoreactive component of gizzard p34K in bovine tissues by immunoblot analysis using a rabbit polyclonal antibody raised against gizzard p34K. The immunoreactive components with molecular weights of 33000-35000 were detected in all smooth muscles from aorta, esophagus, stomach, trachea and uterus. In non-smooth muscle tissues, a 36000-dalton cross-reactive protein was present in adrenal medulla and cortex. The immunoreactive form of gizzard p34K occurred in large amounts in smooth muscles from various bovine tissues.
journal_name
Life Scijournal_title
Life sciencesauthors
Takahashi K,Hiwada K,Kokubu Tdoi
10.1016/0024-3205(87)90151-2subject
Has Abstractpub_date
1987-07-20 00:00:00pages
291-6issue
3eissn
0024-3205issn
1879-0631pii
0024-3205(87)90151-2journal_volume
41pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Acute and chronic opiate exposure impairs the emptying of bile from the gallbladder. In this study, the effects of a 4-day morphine regimen on bile composition were examined. Bile acids and phospholipids concentration of bile obtained from the gallbladder of female morphine-treated (MT) guinea pigs were reduced by 60%...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90231-q
更新日期:1993-01-01 00:00:00
abstract::The aim of this study is to investigate the effect of three cucurbitacins (Cuc) E, D and I on the bilirubin-albumin binding, both in human serum albumin (HSA) and in plasma. Bilirubin-HSA solution and plasma free of cucurbitacins were prepared as well as others containing serial concentrations of cucurbitacins. The co...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.10.005
更新日期:2007-01-16 00:00:00
abstract:AIMS:Splenectomy is sometimes required in bone fracture patients. The present study aims to investigate the effect of splenectomy on fracture healing in rats. MAIN METHODS:Rats underwent osteotomy were subjected to splenectomy. The effects of splenectomy were evaluated at day 0, 3, 15 and 30 post-fracture. Double immu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.12.005
更新日期:2017-03-15 00:00:00
abstract:AIMS:Histone modifications play central epigenetic roles in regulating the entire genome of the cell and cell proliferation. Herein, we investigated the effects of the natural compound, 16-hydroxycleroda-3,13-dien-15,16-olide (PL3), on the expressions of histone-modifying enzymes, and examined how it induces apoptosis ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.09.011
更新日期:2011-12-05 00:00:00
abstract::Chronic voluntary running of mice is known to increase the circadian peak of plasma corticosterone without change in the level of adrenocorticotropic hormone (ACTH). In order to investigate how chronic exercise modulates the circadian HPA axis, we used two weeks of voluntary wheel running of mice and confirmed the sig...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.10.023
更新日期:2007-01-30 00:00:00
abstract:AIMS:The present study was designed to compare the effects of a low-fat diet (LF), calorie restriction (CR), quercetin (Que) and exercise (Ex) on hepatic steatosis in a high-fat (HF) diet-induced obesity prone (OP) model in the perspective of microRNA (miR)-dependent thyroid hormone (TH) synthesis and action. MAIN MET...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.117182
更新日期:2020-02-01 00:00:00
abstract::CYP3A4, the predominant cytochrome P450 (CYP) expressed in human liver, contributes to the metabolism of approximately half the drugs in use today. In general, human-derived cell lines fail to express CYPs. It was previously shown that CYP3A4 mRNA and CYP3A immunoreactive protein are induced by 1alpha,25-dyhydroxyvita...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00262-5
更新日期:2003-05-30 00:00:00
abstract::Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2017.12.025
更新日期:2018-02-15 00:00:00
abstract::It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway. We found that contrary to the earlier reports, two of the phytopathogen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90317-2
更新日期:1989-01-01 00:00:00
abstract::Release of alpha-MSH from the pars intermedia melanotrope cells of Xenopus laevis is regulated by various classical neurotransmitters and neuropeptides. We have examined the effect of two of these regulatory substances, the neurotransmitter GABA and the CRF-related peptide sauvagine, on the adenylate cyclase system of...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90123-s
更新日期:1991-01-01 00:00:00
abstract:AIM:To investigate the cytotoxic effect of Peruvoside and mechanism of action in human cancers. MAIN METHODS:Cell viability was measured by MTT assay and the cell cycle arrest was identified by FACS. Real-time qPCR and western blotting studies were performed to identify important gene and protein expressions in the di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.117147
更新日期:2020-01-15 00:00:00
abstract::Bufalin, which is one of prominent components of Chinese toad venom, was found to decrease the rate of cell proliferation of mouse melanoma clone B16-F10 cells and a concomitant stimulation of expression of its melanotic phenotype. The effect of bufalin on melanogenesis included stimulation of tyrosinase activity and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90213-9
更新日期:1992-01-01 00:00:00
abstract:AIMS:A growing body of evidence shows the cardiovascular benefits of fish oil ingredients, including eicosapentaenoic acid (EPA), in humans and experimental animals. However, the effects of EPA on endothelin (ET)-1-induced cardiomyocyte hypertrophy and the involved signaling cascade are largely unknown. A previous stud...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.04.025
更新日期:2014-11-24 00:00:00
abstract::The aim of this work was to evaluate the effect of the antioxidant stobadine on ischemia/reperfusion-induced injury of the isolated rat heart. Experiments were performed according to Langendorff. Ischemia was induced by stop-flow lasting 30 minutes and the duration of repefusion was 30 minutes. Reperfusion of the isch...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00450-6
更新日期:1999-01-01 00:00:00
abstract::Morphogenesis, the generation of tissue form, is important not only in the embryogenesis of a new individual, but also because a change in morphogenesis may be involved in the establishment of differences between individuals during evolution. Morphogenetic movements are effected in part by coordinated changes in the s...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(83)90844-5
更新日期:1983-10-10 00:00:00
abstract:AIMS:Interleukin-22 (IL-22) promotes thymus recovery and improves T-cell recovery in preclinical allogeneic hematopoietic cell transplant models. However, the correlation between IL-22 and thymus recovery is unknown in human transplant. MATERIALS AND METHODS:In this study, plasma IL-22 levels of transplanted humans we...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118849
更新日期:2021-01-15 00:00:00
abstract::In the course of investigating the binding of imipramine to soluble cellular fractions from brain and leukocytes using equilibrium dialysis, an artifactual binding component was produced. On Scatchard and double-reciprocal plots of the data, the component appeared as a homogenous population of sites displaying a bindi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90405-8
更新日期:1983-07-11 00:00:00
abstract::We investigated the mechanism underlying the priming effect of TNF-alpha on fMLP-stimulated superoxide production in human neutrophils. TNF-alpha enhanced fMLP-stimulated superoxide production in a concentration-dependent manner. TNF-alpha also induced sphingomyelin (SM) hydrolysis and increased the formation of its m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00587-1
更新日期:2000-01-01 00:00:00
abstract::Benzamide riboside (BR) is a novel anticancer agent exhibiting pronounced activity against several human tumor cell lines via the inhibition of inosine 5'-monophosphate dehydrogenase (IMPDH), thereby restricting the biosynthesis of guanylates. Although it has been demonstrated that BR inhibits IMPDH and induces apopto...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.11.026
更新日期:2004-05-28 00:00:00
abstract:AIMS:This study aims to investigate the value of the expression of miR-208, miR-494, miR-499 and miR-1303 in the early diagnosis of acute myocardial infarction (AMI). MAIN METHODS:Patients were divided into two groups: AMI group (n = 41), and Stable angina pectoris (SAP) group (n = 32). Peripheral venous blood was sam...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116547
更新日期:2019-09-01 00:00:00
abstract::SDZ PGU 693 acts as a hypoglycemic agent by stimulating glucose utilisation in insulin-sensitive peripheral tissues, such as skeletal muscle and fat. In a 28 day toxicity study the compound was found to induce hepatocellular hypertrophy in Wistar rats treated with 300 mg/kg/day. To gain insights into the pathomechanis...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00509-8
更新日期:1998-01-01 00:00:00
abstract:AIMS:Numerous studies confirmed the involvement of extracellular vesicles in cancer development and progression. The present study was designed to investigate the glycan composition of ectosomes derived by human cutaneous melanoma (CM) cell lines with the use of lectins. MAIN METHODS:Ectosomes released by primary (WM1...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.06.026
更新日期:2018-08-15 00:00:00
abstract::The in vivo dipyridamole treatment for 16 days produced a significant decrease in chick plasma cholesterol, mainly due to the esterified form. This effect was especially patent in the VLDL + LDL fraction. Similar results were observed in triglyceride content. To our knowledge, this is the first report on this hypolipi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90574-u
更新日期:1991-01-01 00:00:00
abstract::Dietary guidelines published in the past two decades have acknowledged the beneficial effects of myricetin, an important and common type of herbal flavonoid, against several human diseases such as inflammation, cardiovascular pathologies, and cancer. An increasing number of studies have shown the beneficial effects of...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2015.10.004
更新日期:2015-12-01 00:00:00
abstract::[3H]5-HT exhibited specific binding in membrane preparations of Hymenolepis diminuta. The specific binding was saturable, reversible and temperature dependent. A non-linear Scatchard plot was obtained in a concentration range of 11 nM - 1000 nM [3H]5-HT, which could be resolved into sites having apparent dissociation ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90303-1
更新日期:1987-02-23 00:00:00
abstract::Carbachol (CCH), serotonin (5HT), divalent ionophore A23187, cAMP, and certain neuropeptides, i.e. substance P (SP), inhibit the initial rate of uptake (influx) of 22Na into isolated chicken villus enterocytes. All these agents also increase cytosolic Ca. However, the increases stimulated by CCH, 5HT, and cAMP are not...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90506-m
更新日期:1990-01-01 00:00:00
abstract:AIMS:This study analyzed in pithed rats the effect of several acute and prophylactic antimigraine drugs on the CGRPergic vasodepressor sensory outflow, in an attempt to investigate systemic cardiovascular effects in a model unrelated to migraine. MAIN METHODS:Male Wistar pithed rats were pretreated with continuous i.v...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.11.008
更新日期:2009-01-30 00:00:00
abstract::MicroRNAs plays important role in the development of myocardial infarction (MI). The aim of this study was to analyze whether miR-429 has effect on the process of autophagy in myocardial anoxia/reoxygenation (AR) or ischemia/reperfusion (IR) injury and explore the underlying mechanism. The results showed that miR-429 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116842
更新日期:2019-10-15 00:00:00
abstract::Treatment of primary cultured chondrocytes from rabbit articular cartilage with interleukin-1 (IL-1)alpha and plasminogen induced the production of pro-matrix metalloproteinase 1 (proMMP-1/interstitial collagenase), proMMP-3 (stromelysin 1) and proMMP-9 (gelatinase B), as well as their active forms. Human urinary tryp...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00261-6
更新日期:1998-01-01 00:00:00
abstract::Bacitracin (BAC) U.S.P., obtained in the form of sterile powder, elicits dose-dependent and non-tachyphylactic contractions of the rabbit isolated aorta and of other rabbit vessels. The use of several pharmacologic antagonists suggests that BAC is a 5-hydroxytryptamine mimetic in aortic strips, since the antibiotic is...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90355-u
更新日期:1990-01-01 00:00:00