Abstract：
:The aim of this work was to evaluate the effect of the antioxidant stobadine on ischemia/reperfusion-induced injury of the isolated rat heart. Experiments were performed according to Langendorff. Ischemia was induced by stop-flow lasting 30 minutes and the duration of repefusion was 30 minutes. Reperfusion of the ischemic heart induced dysrhythmias, with the most severe ones occurring in the first minutes of reperfusion. A significant increase in coronary perfusion pressure was observed starting after 15 min of reperfusion. Stobadine (10(-6) M applied 3 minutes before onset of ischemia and during reperfusion) prevented the deleterious effects to develop fully. The protective effect of stobadine observed in our experiments seems to be a consequence of its antioxidant properties.
journal_name
Life Scijournal_title
Life sciencesauthors
Knezl V,Sotníková R,Okruhlicová L,Navarová Jdoi
10.1016/s0024-3205(99)00450-6subject
Has Abstractpub_date
1999-01-01 00:00:00pages
1931-3issue
18-19eissn
0024-3205issn
1879-0631pii
S0024-3205(99)00450-6journal_volume
65pub_type
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