Enhancement of secondary metabolite production using the antibiotic gradient-plate technique.

abstract：:This in vitro study was conducted to determine whether tachyphylaxis of guinea pig airway to furosemide occurs under conditions that produce tachyphylaxis to the beta 2-adrenoceptor agonist, salbutamol. Isometric tension was measured in tracheal rings bathed in HEPES buffer from 4-6 d newborn guinea pigs of either sex...

journal_title：Life sciences

authors： Iwamoto LM,Wilson VL,Lavallee SL,Fujiwara N,Ayau EL,Nakamura KT

更新日期：1996-01-01 00:00:00

abstract：AIMS:Fructose administration induces hepatic oxidative stress, insulin resistance, inflammatory and metabolic changes. We tested their potential pathogenic relationship and whether these alterations can be prevented by R/S-α-lipoic acid. MAIN METHODS:Wistar rats received during 21days a commercial diet or the same die...

journal_title：Life sciences

authors： Castro MC,Massa ML,Arbeláez LG,Schinella G,Gagliardino JJ,Francini F

更新日期：2015-09-15 00:00:00

abstract：:Recent immunohistochemical and radioimmunochemical observations have demonstrated a differential distribution of immunoreactive dynorphin (DYN) in rat brain. The presence of DYN immunoreactivity in a major intrinsic fiber pathway within the rat hippocampus (the mossy fiber system) has led us to evaluate the possible r...

journal_title：Life sciences

authors： Henriksen SJ,Chouvet G,Bloom FE

更新日期：1982-10-18 00:00:00

abstract：:The present study investigates the effect of a pituitary hormone (LH) and a thymic factor (Thymosin Fraction 5 = TF5) on in vitro and in vivo spleen cell proliferative response of 2, 6 and 8-month-old Balb/c mice. In vitro experiments showed that the addition of LH at various concentrations (0.5, 5, 50 or 500 ng/ml) t...

journal_title：Life sciences

authors： Rouabhia M,Ghanmi Z,Chakir J,Othmane O,Deschaux P

更新日期：1990-01-01 00:00:00

abstract：AIMS:In our model, we aimed to explore the cytotoxicity of 5-Aza-2'-deoxycytidine (5-Aza-CdR) against the colorectal cell line, Lovo, and further characterize the possible mechanisms. MAIN METHODS:After Lovo cells were treated with 5-Aza-CdR at different concentrations for different periods of time, the cell viability...

journal_title：Life sciences

authors： Deng T,Zhang Y

更新日期：2009-02-27 00:00:00

abstract：:The effect on thermonociceptive threshold of intrathecally (i.t.) administered angiotensin II (Ang II) was assessed in the rat tail-flick test. Rats were pretreated, 15 min earlier, with i.t. naloxone (opiate antagonist), losartan (Ang II selective antagonist at AT1 receptor) or [Sar1, Leu8] Ang II (non selective Ang ...

journal_title：Life sciences

authors： Toma N,Sgambato V,Couture R

更新日期：1997-01-01 00:00:00

abstract：AIMS:Hydrogen sulfide (H(2)S) at low concentrations serves as a physiological endogenous vasodilator molecule, while at higher concentrations it can trigger cytotoxic effects. The aim of our study was to elucidate the potential mechanisms responsible for the effects of H(2)S on vascular tone. MAIN METHODS:We measured ...

journal_title：Life sciences

authors： Kiss L,Deitch EA,Szabó C

更新日期：2008-10-24 00:00:00

abstract：AIMS:Salivary gland dysfunction is a common complication of diabetes mellitus (DM). Long non-coding RNA (lncRNA) is evidenced to involve in the functional regulation of salivary gland, however, its role in DM-impaired gland is unknown. Therefore, this study aimed to investigate the expression profiles and functional ne...

journal_title：Life sciences

authors： Huang Y,Liu HM,Wu LL,Yu GY,Xiang RL

更新日期：2021-01-04 00:00:00

abstract：:We administered intravenous adenosine to 11 neonatal rabbits. Adenosine depressed respiration in 10 of 11 rabbits. For the group as a whole the adenosine-induced respiratory depression was highly significant (p less than 0.001). After aminophylline administration to the same animals the respiratory effect of intraveno...

journal_title：Life sciences

authors： Watt AH,Buss DC,Routledge PA

更新日期：1987-01-05 00:00:00

abstract：:Diazepam (0.4-4 mg/kg i.p.) reduced the spontaneous tonic activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus muscle of spastic mutant Han-Wistar rats in a dose-dependent manner. The muscle relaxant effect of diazepam was antagonized by the benzodiazepine antagonists Ro 15-1788 (5 mg/kg i.p.), ...

journal_title：Life sciences

authors： Schwarz M,Turski L,Sontag KH

更新日期：1984-10-01 00:00:00

abstract：:Effects of baicalein and wogonin, the major flavonoids of Scutellariae radix, on cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) were studied in C57BL/6J mice. One-week treatment of mice with a liquid diet containing 5 mM baicalein resulted in 29%, 14%, 36%, 28%, and 46% ...

journal_title：Life sciences

authors： Ueng YF,Shyu CC,Lin YL,Park SS,Liao JF,Chen CF

更新日期：2000-09-22 00:00:00

abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...

journal_title：Life sciences

authors： Matsuda H,Li Y,Yoshikawa M

更新日期：1999-01-01 00:00:00

abstract：AIMS:The renin-angiotensin system (RAS) plays a major role in cardiovascular diseases in postmenopausal women, but little is known about its importance to lower urinary tract symptoms. In this study we have used the model of ovariectomized (OVX) estrogen-deficient rats to investigate the role of RAS in functional and m...

journal_title：Life sciences

authors： Ramos-Filho AC,A Faria J,Calmasini FB,Teixeira SA,Mónica FZ,Muscará MN,Gontijo JA,Anhê GF,Zanesco A,Antunes E

更新日期：2013-11-19 00:00:00

abstract：AIMS:We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet. MAIN METHODS:Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Di...

journal_title：Life sciences

authors： Barros MAV,de Brito Alves JL,Barros RGN,Santana E Silva M,Nasser S,Tourneur Y,Leandro CVG,Vidal H,Pirola L,Costa-Silva JH

更新日期：2020-12-15 00:00:00

abstract：:The localization of vasoactive intestinal polypeptide (VIP) in the male genitourinary tract was investigated in the rabbit and man by means of radioimmunoassay and immunohistochemistry. In addition, the in vitro effect of VIP upon penile smooth muscle from man, the Vervet monkey, and the rabbit was investigated. Signi...

journal_title：Life sciences

authors： Willis EA,Ottesen B,Wagner G,Sundler F,Fahrenkrug J

更新日期：1983-07-25 00:00:00

abstract：AIMS:Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are...

journal_title：Life sciences

authors： Cui YL,Xue RQ,Xi He,Ming Zhao,Yu XJ,Liu LZ,Wu Q,Si Yang,Li DL,Zang WJ

更新日期：2019-04-01 00:00:00

abstract：:Oxymorphazone (at doses of 50-200 mg/kg) was found to be a relatively weak antinociceptive drug in intact frog (Rana esculenta) when acetic acid was used as pain stimulus. Frogs remained analgesic for at least 48 hrs following oxymorphazone (200 mg/kg) administration. The ligand increased the latency of wiping reflex ...

journal_title：Life sciences

authors： Benyhe S,Hoffmann G,Varga E,Hosztafi S,Toth G,Borsodi A,Wollemann M

更新日期：1989-01-01 00:00:00

abstract：:Involvement of a central histaminergic mechanism in the stimulating effect of beta-endorphin (beta-End) on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, was investigated in conscious rats. The rise in serum corticosterone levels, induced by beta-End injected intraventricu...

journal_title：Life sciences

authors： Turoń M,Tytoń J,Bugajski J

更新日期：1991-01-01 00:00:00

abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...

journal_title：Life sciences

authors： Sandrini M,Vitale G,Vergoni AV,Ottani A,Bertolini A

更新日期：1997-01-01 00:00:00

abstract：:Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...

journal_title：Life sciences

authors： Filloux F,Richards TJ,Huff GF,Wamsley JK

更新日期：1991-01-01 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

journal_title：Life sciences

authors： Privratsky JR,Newman DK,Newman PJ

更新日期：2010-07-17 00:00:00

abstract：:Three cholecystokinin type B (CCKB) receptor antagonists were labelled with 11C and evaluated ex vivo in rat biodistribution studies. The CCKB antagonists were YF 476 and two other compounds of the basic 3-ureido-1,4-benzodiazepine class. Following tail-vein administration of [11C]-YF 476 exceedingly low levels of rad...

journal_title：Life sciences

authors： Wilson AA,Jin L,Garcia A,DaSilva JN,Houle S

更新日期：2001-02-02 00:00:00

abstract：:The ontogeny of endothelin (ET) system in rats was studied in preterm (18 days of gestation), term (21 days of gestation) and 1 week post term rats. Brains were dissected out and (1) processed for the estimation of endogenous ET-1 by RIA and (2) membranes were prepared for radioreceptor binding. Receptor characteristi...

journal_title：Life sciences

authors： Gulati A,Rebello S,Chari G,Bhat R

更新日期：1992-01-01 00:00:00

abstract：:Using absorption spectroscopy we have found that metallothionein I at concentrations as low as 1 microM reduces ferricytochrome c. This reduction is more potent than that of another abundant intracellular thiol, glutathione. Also, oxidation of ferricytochrome c which had been reduced by metallothionein I occurs more s...

journal_title：Life sciences

authors： Simpkins C,Eudaric P,Torrence C,Yang Z

更新日期：1993-01-01 00:00:00

abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...

journal_title：Life sciences

authors： Zhao Y,Shen F,Gong M,Jin L,Ren X,Liu K,Lu J

更新日期：2020-06-15 00:00:00

abstract：:In order to estimate the intestinal stability of ebiratide [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2], a novel adrenocorticotropic hormone (ACTH) analogue, after oral administration, the hydrolytic properties of ebiratide were determined in the rat small intestinal fluid and mucosal homogenates. Ebiratide was extr...

journal_title：Life sciences

authors： Okagawa T,Fujita T,Murakami M,Yamamoto A,Shimura T,Tabata S,Kondo S,Muranishi S

更新日期：1994-01-01 00:00:00

abstract：:Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy in preventing soman...

journal_title：Life sciences

authors： Wang YA,Zhou WX,Li JX,Liu YQ,Yue YJ,Zheng JQ,Liu KL,Ruan JX

更新日期：2005-11-26 00:00:00

abstract：:A previous communication from this laboratory reported that brain uptake of libenzapril, a small polar molecule, was enhanced in chronic hypertension (1). The objective of this investigation was to determine if this was a more generalized phenomenon. Therefore, experiments were undertaken to examine the effect of chro...

journal_title：Life sciences

authors： Tang JP,Xu ZQ,Douglas FL,Rakhit A,Melethil S

更新日期：1993-01-01 00:00:00

abstract：:A sensitive and specific radioimmunoassay for substance P has been developed and its full characterisation is described. The assay was used to investigate the stability of substance P in tissue in order to establish the optimal conditions of tissue storage for maximal recovery of the peptide. The results indicate unex...

journal_title：Life sciences

authors： McGregor GP,Bloom SR

更新日期：1983-02-07 00:00:00

abstract：:Inhibitors of neuronal norepinephrine (NE) uptake are useful for the treatment of a variety of diseases including depression and urinary incontinence. In the present study, we synthesized and evaluated a novel analog of the potent and selective NE uptake inhibitor, nisoxetine. Thionisoxetine more potently inhibited th...

journal_title：Life sciences

authors： Gehlert DR,Hemrick-Luecke SK,Schober DA,Krushinski J,Howbert JJ,Robertson DW,Wong DT,Fuller RW

更新日期：1995-01-01 00:00:00