Abstract:
AIMS:Salivary gland dysfunction is a common complication of diabetes mellitus (DM). Long non-coding RNA (lncRNA) is evidenced to involve in the functional regulation of salivary gland, however, its role in DM-impaired gland is unknown. Therefore, this study aimed to investigate the expression profiles and functional networks of lncRNA in the parotid glands (PGs) of DM mice. MAIN METHODS:Microarray was used to detect lncRNA and messenger RNA (mRNA) expression profiles in the PGs from db/db and db/m mice. Eleven differently expressed (DE) lncRNAs validated by qRT-PCR were selected for coding-non-coding gene co-expression (CNC) and competing endogenous RNA (ceRNA) network analysis, as well as the following Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Pearson's coefficient correlation analysis was used to analyze the correlations between DE lncRNAs expression and DM pathology. KEY FINDINGS:By using a 2-fold change and P < 0.05 as the cutoff criteria, 1650 DE lncRNAs (758 upregulated and 892 downregulated) and 1073 mRNAs (563 upregulated and 510 downregulated) were identified in the PGs of db/db mice compared to db/m mice. GO and KEGG analysis of DE mRNA suggested that activated inflammation response and downregulated ion transport might count for the dysfunction of diabetic PG. CNC and ceRNA networks analysis of 11 DE lncRNAs showed that the inflammation process and its related signaling pathways including advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling pathway in diabetic complications, cytokine-cytokine receptor interaction, chemokine signaling pathway, apoptosis, and cell adhesion molecules were significantly enriched. The alterations of lncRNAs were closely correlated with higher blood glucose and serum insulin levels in mice. SIGNIFICANCE:We identified multiple lncRNAs/mRNAs and several signaling pathways that may involve in the pathogenesis of diabetic salivary injury, providing new insight into potential target of diabetic hyposalivation.
journal_name
Life Scijournal_title
Life sciencesauthors
Huang Y,Liu HM,Wu LL,Yu GY,Xiang RLdoi
10.1016/j.lfs.2020.119009subject
Has Abstractpub_date
2021-01-04 00:00:00pages
119009eissn
0024-3205issn
1879-0631pii
S0024-3205(20)31769-0journal_volume
268pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90130-j
更新日期:1990-01-01 00:00:00
abstract::Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progressi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118509
更新日期:2020-12-01 00:00:00
abstract::Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90319-0
更新日期:1988-01-01 00:00:00
abstract::The role of serotonin (5-HT) in the regulation of steroidogenesis in the ovary via 5-HT2 receptor was studied in normal cycling rats and their preovulatory follicles. Oral administration of ketanserin (KET), a selective 5-HT2 antagonist, at 10 mg/kg BW at 1100h on the day of proestrus resulted in a marked decrease in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90713-d
更新日期:1993-01-01 00:00:00
abstract::Several different vasodilator substances can be released by vascular endothelium in response to mechanical stimuli and vasoactive agents. The purpose of this study was to determine whether there is a male-female difference in the relative contributions of nitric oxide (NO) and endothelium-derived hyperpolarizing facto...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01851-9
更新日期:2002-08-23 00:00:00
abstract:AIMS:Chloropropanol is a contaminant produced during food processing, and 1,3-dichloro-2-propanol (1,3-DCP) is one of the most-studied and most common chloropropanol-related food contaminants. Epigallocatechin-3-gallate (EGCG) is the most abundant ester catechin in tea polyphenols. We studied the potential therapeutic ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.08.007
更新日期:2018-09-15 00:00:00
abstract::The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.05.043
更新日期:2016-07-15 00:00:00
abstract:AIMS:Pulmonary hypertension (PH) is a proliferative disorder characterized by enhanced proliferation and suppressed apoptosis of intrapulmonary vascular smooth muscle cells. Recently, network-based bioinformatics have identified let-7 family, a tumor suppressive microRNA, regulate multiple interacting targets relevant ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.11.020
更新日期:2017-02-01 00:00:00
abstract::The effects of various vasorelaxant agents on aortas from control and genetically diabetic rats were examined. The concentration-response curves for the isoproterenol (ISO)-induced relaxation of both aortic strips with and without endothelium are shifted to the right in diabetic rats. The relaxation responses of diabe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90287-y
更新日期:1992-01-01 00:00:00
abstract::This study was undertaken to investigate whether or not alpha 2-adrenergic pathways would negatively modulate the hypothalamic somatostatin release in rats. To induce pharmacological changes in SS release, three groups of male Sprague-Dawley rats (n = 30/group) were separately anesthetized by ip administration of uret...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90277-a
更新日期:1993-01-01 00:00:00
abstract::Sexual interactions have multiple effects on oxytocin systems in the brain. In the present study we observed that allowing estrogen-progesterone treated ovariectomized rats to be mounted ten times by a male significantly decreased the density (beta max) of thymic oxytocin receptors. Animals were ovariectomized and aft...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90467-h
更新日期:1993-01-01 00:00:00
abstract::Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00226-4
更新日期:1998-01-01 00:00:00
abstract:AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.03.022
更新日期:2014-05-08 00:00:00
abstract::This study was conducted to investigate SAFB-induced apoptosis of mast cells as it pertains to both its basic drug mechanism and the potential therapeutics of the pathologic conditions accompanying mast cell proliferation. SAFB induced many apoptotic manifestations as evidenced by changes in cell morphology, generatio...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01140-7
更新日期:2001-06-22 00:00:00
abstract:AIMS:Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF. MATERIALS AND METHODS:We analyzed mRNA of human non-failing...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.01.021
更新日期:2018-03-01 00:00:00
abstract::The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is rapidly metabolized to a 1-methyl-4-phenylpyridinium species (MPP+) in the squirrel monkey. After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the hi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90060-8
更新日期:1985-01-21 00:00:00
abstract::Leptin-deficient Ob/Ob mice are hypometabolic and have reduced fat cell expression of beta-3 adrenoceptors (ARs). To determine whether leptin repletion restores beta-3 AR number, C57BL/6J Ob/Ob mice were given exogenous leptin (5 mg/kg I.P. daily) for 21 days. Leptin administration reduced body weight from 43.1+/-3.7 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00358-5
更新日期:1997-01-01 00:00:00
abstract::In order to assess the relative cytokine contribution to endotoxin stimulation of pituitary-adrenocortical hormone secretion, we measured plasma levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF alpha), adrenocorticotropin (ACTH) and corticosterone following lipopolysaccharide (LPS) challenge in rats....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00780-7
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:This study investigated the role of long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in kidney injury induced by urine-derived sepsis (US). MATERIALS AND METHODS:An Escherichia coli suspension was injected into the distal ureter of adult male Sprague Dawley rats to establish a US model. Lipo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.08.041
更新日期:2018-10-01 00:00:00
abstract::The aim of this study was to verify, by means of functional methods, whether the circadian rhythm changes adrenergic response patterns in the epididymal half of the vas deferens isolated from control rats as well as from rats submitted to acute stress. The experiments were performed at 9:00 a.m., 3:00 p.m., 9:00 p.m.,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.02.012
更新日期:2005-08-26 00:00:00
abstract:AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.11.019
更新日期:2019-01-01 00:00:00
abstract:AIMS:The beneficial effects of cannabinoid type 2 receptor (CB2R) activation have been verified in various tissue repair processes. Our recent study revealed CB2R activation promotes myogenesis partly through Nrf2 signaling in a mouse skeletal muscle ischemia-reperfusion (IR) injury model. Other relevant mechanisms nee...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117989
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The prevalence and mortality of the outbreak of the COVID-19 pandemic show marked geographic variation. The presence of several subtypes of the coronavirus and the genetic differences in the populations could condition that variation. Thus, the objective of this study was to propose variants in genes that en...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118313
更新日期:2020-11-01 00:00:00
abstract::Rats treated chronically with the anticancer agent adriamycin (1.5 mg/kg/week X 14 weeks) exhibited cardiac and renal lesions typical of anthracycline toxicity, and had serum hyperlipidemia characterized by 4 to 10 fold elevations in all lipoprotein classes. Heparin-releasable lipoprotein lipase activity measured in p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90167-5
更新日期:1985-02-18 00:00:00
abstract::The relative affinities of nortriptyline (NT) and its 10-hydroxymetabolites to rat brain muscarinic acetylcholine receptors have been determined by competition with 3H-quinuclidinyl benzilate binding. It is shown that the major NT metabolite, E-10-OH-NT, has only 1/18 the affinity of NT for the muscarinic receptor. Si...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90395-3
更新日期:1984-09-24 00:00:00
abstract::Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2006.05.017
更新日期:2006-09-20 00:00:00
abstract::We have previously shown that matrix metalloproteinases (MMPs) play a role in osteoclastic bone resorption by facilitating migration of osteoclastic cells toward bone surface through matrices. Of MMPs identified so far, MMP-9 is likely the most important proteinase for the action, since osteoclasts express this enzyme...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.05.024
更新日期:2006-09-20 00:00:00
abstract::The neurological mutant whirler mouse, one of several strains of waltzing mice, may be suitable as an animal model for testing studies relative to hyperkinesis. As in hyperkinetic children, behaviorally the mice are extremely restless, nervous, excitable, irritable and aggressive but also show symptoms of rotation beh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90404-7
更新日期:1985-08-05 00:00:00
abstract::The effects of methadone and morphine on fetal behavior were studied following their administration to either the mother (5micrograms/kg/min) or fetus (0.5micrograms/kg maternal wt./min) using the chronically-instrumented pregnant ewe model. Fourteen unanesthetized, unrestrained pregnant ewes between 130-141 days gest...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90584-2
更新日期:1983-01-01 00:00:00
abstract::Alpha adrenergic receptors are identified on basolateral plasma membranes derived from proximal tubular epithelial cells. The density of alpha 2 receptors was over two-fold greater than alpha 1 receptors. The basolateral membranes were devoid of beta receptors. These results support previous demonstrations of alpha ad...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90259-7
更新日期:1988-01-01 00:00:00