In vivo cellular responses to electrophoretically applied dynorphin in the rat hippocampus.

abstract：:Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptor in the rabbit mesenteric blood vessels. It had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro study...

journal_title：Life sciences

authors： Sun FY,Zhu H,Zhang LM,Xu XR,Zhang AZ

更新日期：1987-06-15 00:00:00

abstract：:The behavioral response induced by the intravesical instillation of capsaicin has been investigated in catheter-implanted, freely moving, conscious male and female rats. Intravesical instillation of capsaicin (25 nmol/rat in 0.5 ml) evoked an intense licking directed toward the lower abdominal and perineal skin which ...

journal_title：Life sciences

authors： Lecci A,Giuliani S,Lazzeri M,Benaim G,Turini D,Maggi CA

更新日期：1994-01-01 00:00:00

abstract：AIMS:DNA methylation and hydroxymethylation are significantly related to the occurrence and development of coronary heart disease (CHD) and atherosclerosis (AS). 5-Methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) are used to assess DNA methylation and hydroxymethylation levels, respectively. However, 5-mC and ...

journal_title：Life sciences

authors： Jiang D,Sun M,You L,Lu K,Gao L,Hu C,Wu S,Chang G,Tao H,Zhang D

更新日期：2019-05-01 00:00:00

abstract：:We have previously shown that matrix metalloproteinases (MMPs) play a role in osteoclastic bone resorption by facilitating migration of osteoclastic cells toward bone surface through matrices. Of MMPs identified so far, MMP-9 is likely the most important proteinase for the action, since osteoclasts express this enzyme...

journal_title：Life sciences

authors： Ishibashi O,Niwa S,Kadoyama K,Inui T

更新日期：2006-09-20 00:00:00

abstract：AIMS:The purposes of this study were to determine whether Cervi Pantotrichum Cornu (CPC) has osteogenic activities in human osteoblastic MG-63 cells and to investigate the underlying molecular mechanism. MAIN METHODS:The effects of CPC on alkaline phosphatase activity, collagen synthesis, and calcium deposits were mea...

journal_title：Life sciences

authors： Kim JH,Jung TY,Seo J,Lee S,Kim MG,Leem KH,Lim SC

更新日期：2014-01-14 00:00:00

abstract：:The objective of this study was to determine the primary event that occurs in Ca2+-regulatory sarcoplasmic-reticular (SR) proteins during subacute transition from concentric/mechanically-compensated left ventricular (LV) hypertrophy to eccentric/decompensated hypertrophy. Using Dahl salt-sensitive rats with hypertensi...

journal_title：Life sciences

authors： Yoneda T,Kihara Y,Ohkusa T,Iwanaga Y,Inagaki K,Takeuchi Y,Hayashida W,Ueyama T,Hisamatsu Y,Fujita M,Hatac S,Matsuzaki M,Sasayama S

更新日期：2001-11-30 00:00:00

abstract：AIMS:Salivary gland dysfunction is a common complication of diabetes mellitus (DM). Long non-coding RNA (lncRNA) is evidenced to involve in the functional regulation of salivary gland, however, its role in DM-impaired gland is unknown. Therefore, this study aimed to investigate the expression profiles and functional ne...

journal_title：Life sciences

authors： Huang Y,Liu HM,Wu LL,Yu GY,Xiang RL

更新日期：2021-01-04 00:00:00

abstract：:In human tumors changes in angiogenesis and expression of extracellular matrix-degrading enzymes occur simultaneously during invasion and metastasis. Tissues from 20 biopsies of human neuroblastoma (NB) were investigated immunohistochemically by using an antibody against factor VIII to determine their microvessel numb...

journal_title：Life sciences

authors： Ribatti D,Surico G,Vacca A,De Leonardis F,Lastilla G,Montaldo PG,Rigillo N,Ponzoni M

更新日期：2001-01-26 00:00:00

abstract：:The present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthe...

journal_title：Life sciences

authors： Ko JK,Tang F,Cho CH

更新日期：1997-01-01 00:00:00

abstract：:Hypoxia-induced neuronal damage and glutamate release were investigated in a N(2)- or in xenon-atmosphere for embryonic rat cortical neurons; cellular damage and glutamate over-release were observed in N(2)-treated cells whereas xenon protected the cells from the hypoxic insult. The protective effect of xenon was stro...

journal_title：Life sciences

authors： Petzelt C,Blom P,Schmehl W,Müller J,Kox WJ

更新日期：2003-03-14 00:00:00

abstract：:We investigated serum levels of type III procollagen aminopeptide (CIII), 7S type IV collagen (CIV), and tissue inhibitor of metalloproteinase (TIMP) in 33 patients with type II diabetes mellitus (DM) without uremia (serum creatinine less than 1.5 mg/dl). The patients were divided into three groups based on measuremen...

journal_title：Life sciences

authors： Ishimura E,Nishizawa Y,Shoji S,Mori H

更新日期：1996-01-01 00:00:00

abstract：:Superoxide dismutase (SOD) levels, thought to be the first cellular defence against free radicals, were studied in the nonobese diabetesprone (NOD-p) mouse, an animal model of type 1 diabetes in which about 100% of females and 20% of males become diabetic. Nonobese diabetes nonprone (NON-p) mice were used as controls....

journal_title：Life sciences

authors： Papaccio G,Frascatore S,Pisanti FA,Latronico MV,Linn T

更新日期：1995-01-01 00:00:00

abstract：:Subcutaneous administration of naloxone at 1 to 10 mg/kg produced a dose-related decrease in feed intake of broiler chicks. Food deprivation for 3, 6, 12, and 24 hours produced a significant increase in feed intake compared to non-food deprived birds. Subcutaneous administration of naloxone at 1 to 10 mg/kg failed to ...

journal_title：Life sciences

authors： Sangiah S,Alavi FK,Teeter RG,Amouzadeh HR,Mauromoustakos A

更新日期：1988-01-01 00:00:00

abstract：:To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ...

journal_title：Life sciences

authors： Hou YC,Hsiu SL,Ching H,Lin YT,Tsai SY,Wen KC,Chao PD

更新日期：2005-01-21 00:00:00

abstract：AIMS:Hyperthermia is a characteristic functional effect of sleep deprivation (SD). We hypothesize here that prostaglandin E2 (PGE2) could be involved in hyperthermia induced by sleep deprivation. MAIN METHODS:To address this issue we examined the effects of a selective cyclo-oxygenase-2 inhibitor (COX-2) agent on hype...

journal_title：Life sciences

authors： Palma BD,Nobrega JN,Gomes VL,Esumi LA,Seabra ML,Tufik S,Hipolide DC

更新日期：2009-02-27 00:00:00

abstract：AIMS:Benzodiazepines (BZDs) produce various pharmacological actions by binding to and allosterically regulating GABAA receptors. Several in vitro studies have demonstrated diazepam, the prototypic BZD, produces a high-dose action that cannot be countered with the classical BZD-binding site antagonist flumazenil. Here, ...

journal_title：Life sciences

authors： Cao Y,Yan H,Yu G,Su R

更新日期：2019-12-15 00:00:00

abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...

journal_title：Life sciences

authors： Matsuda H,Li Y,Yoshikawa M

更新日期：1999-01-01 00:00:00

abstract：:Physiological, pharmacological and toxicological responses to two regimens of cocaine administration were compared between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. An initial experiment examined renal excretory and hemodynamic function in response to an acute volume load in anesthetized SHR and WK...

journal_title：Life sciences

authors： Ishizuka Y,Rockhold RW,Kirchner K,Hoskins B,Ho IK

更新日期：1989-01-01 00:00:00

abstract：:The aim of this study was to assess the anxiolytic effect of berberine (abbrev. BER) using two experimental anxiety models in the mouse. In the black and white test of anxiety, berberine (100, 500 mg/kg) produced an increase in the first time entry, time spent in the white section, and total changes between two compar...

journal_title：Life sciences

authors： Peng WH,Wu CR,Chen CS,Chen CF,Leu ZC,Hsieh MT

更新日期：2004-10-01 00:00:00

abstract：:Testosterone propionate, cortisone, or sesame oil vehicle were given to rats during the last week of pregnancy so that effects of the hormones on anogenital distance, breeding capacity and vaginal opening of the female progeny could be contrasted. Testosterone significantly increased anogenital distance and delayed va...

journal_title：Life sciences

authors： McCoy SJ,Shirley BA

更新日期：1992-01-01 00:00:00

abstract：:The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...

journal_title：Life sciences

authors： Uchida S,Kato Y,Hirano K,Kagawa Y,Yamada S

更新日期：2007-04-03 00:00:00

abstract：:Intravenous (i.v.) or intrarenal arterial (i.r.a.) injection of big endothelin-1 (big ET-1) (1.6 nmol/kg) in anesthetized rats produced a significant increase in mean arterial pressure (MAP), a decrease in renal blood flow (RBF) and an increase in renal vascular resistance (RVR). Although the pressor responses to big ...

journal_title：Life sciences

authors： Fujita K,Matsumura Y,Kita S,Hisaki K,Takaoka M,Morimoto S

更新日期：1994-01-01 00:00:00

abstract：:Previous research has shown that the CAMK (calcium/calmodulin dependent protein kinase) inhibitor, KN62, can lead to reductions in insulin stimulated glucose transport. Although controversial, an L-type calcium channel mechanism has also been hypothesized to be involved in insulin stimulated glucose transport. The pur...

journal_title：Life sciences

authors： Wright DC,Fick CA,Olesen JB,Lim K,Barnes BR,Craig BW

更新日期：2004-01-02 00:00:00

abstract：:In recent years, serum S100B has been used as a secondary endpoint in some clinical trials, in which serum S100B has successfully indicated the benefits or harm done by the tested agents. Compared to clinical stroke studies, few experimental stroke studies report using serum S100B as a surrogate marker for estimating ...

journal_title：Life sciences

authors： Tanaka Y,Koizumi C,Marumo T,Omura T,Yoshida S

更新日期：2007-08-02 00:00:00

abstract：:Polyamines (spermidine, spermine and putrescine) inhibited the adenylate cyclase activity in a concentration dependent manner in human erythrocyte plasma membranes. Spermidine (Spd) exhibited more inhibitory effect than spermine (Spm) and putrescine (Put). On the contrary, the addition of amino acids (arginine, glutam...

journal_title：Life sciences

authors： Khan NA,Quemener V,Moulinoux P

更新日期：1990-01-01 00:00:00

abstract：:Oxidative stress has been implicated to play an important role in the pathogenesis of diabetic neuropathy, which is the most common complication of diabetes mellitus affecting more than 50% of diabetic patients. In the present study, we have investigated the effect of U83836E [(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimi...

journal_title：Life sciences

authors： Sayyed SG,Kumar A,Sharma SS

更新日期：2006-07-17 00:00:00

abstract：AIMS:MicroRNA-1 (miR-1) has been demonstrated as a tumor-suppressive miRNA, which shows a down-regulated pattern in several human malignancies including hepatocellular carcinoma (HCC). However, the pathophysiologic roles of miR-1 and their mechanisms in HCC tumorigenesis are still not totally elucidated. MAIN METHODS:...

journal_title：Life sciences

authors： Li D,Yang P,Li H,Cheng P,Zhang L,Wei D,Su X,Peng J,Gao H,Tan Y,Zhao Z,Li Y,Qi Z,Rui Y,Zhang T

更新日期：2012-10-05 00:00:00

abstract：:The feasibility of visualizing the heterogeneity of benzodiazepine (BDZ) receptors in the brain of living baboons was investigated using Positron Emission Tomography. Ethyl 8-fluoro-5,6-dihydro-5-methyl 6-oxo-4H-imidazo (1,5-a) (1, 4) benzodiazepine-3-carboxylate (RO 15 1788) labelled by carbon 11 (11C-RO 15 1788) was...

journal_title：Life sciences

authors： Mazière M,Hantraye P,Kaijima M,Dodd R,Guibert B,Prenant C,Sastre J,Crouzel M,Comar D,Naquet R

更新日期：1985-04-29 00:00:00

abstract：:Human uridinediphosphate-glucuronosyltransferase 1A1 (UGT1A1) was expressed in Salmonella typhimurium TA1535 cells by transfection of the cells with plasmids carrying the UGT1A1 cDNA. UGT1A1 cDNA was isolated by a polymerase chain reaction from human liver total RNA and was inserted into the pSE420 plasmid, linked to ...

journal_title：Life sciences

authors： Fujita K,Mogami A,Hayashi A,Kamataki T

更新日期：2000-04-07 00:00:00

abstract：:The effects of the mixed class I and II mGLUR agonist (+) 1S,3R-trans-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) and antagonists (+) alpha-methyl-4-carboxyphenylglycine (MCPG) and L-2-amino-3-phosphonopropionic acid (L-AP3) on the basal neuronal excitability and on the expression of in vitro epileptiform activity...

journal_title：Life sciences

authors： Tebano MT,Marinelli S,Sagratella S

更新日期：1997-01-01 00:00:00