Abstract：
:A previous communication from this laboratory reported that brain uptake of libenzapril, a small polar molecule, was enhanced in chronic hypertension (1). The objective of this investigation was to determine if this was a more generalized phenomenon. Therefore, experiments were undertaken to examine the effect of chronic hypertension on the brain uptake of tryptophan (an amino acid with high brain permeability) and glutamic acid (one with low permeability). Brain concentrations of these two amino acids were 5- to 12-fold greater in chronic hypertensive rats, as compared to normotensive rats; the corresponding brain uptake index (BUI) values were 2- to 5-fold higher in the former group. Since blood-brain barrier transport of amino acids involve both saturable (carrier) and non-saturable (most likely, diffusion via pores) mechanisms, data from this study show that hypertension can enhance BBB transport of amino acids by affecting one or both of these pathways.
journal_name
Life Scijournal_title
Life sciencesauthors
Tang JP,Xu ZQ,Douglas FL,Rakhit A,Melethil Sdoi
10.1016/0024-3205(93)90033-ysubject
Has Abstractpub_date
1993-01-01 00:00:00pages
PL417-20issue
25eissn
0024-3205issn
1879-0631pii
0024-3205(93)90033-Yjournal_volume
53pub_type
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