Glucocorticoids increase beta-adrenoceptors on human intact lymphocytes in vitro.

abstract：:The herbal medicine, Echinacea, is used for treatment and prevention of upper respiratory tract infections. Among the phytochemicals found in Echinacea, the bioavailable alkylamides are thought to be the compounds responsible for its effects on the human immune system. Cytochrome P450 enzymes (P450s) appear to be the ...

journal_title：Life sciences

authors： Toselli F,Matthias A,Gillam EM

更新日期：2009-07-17 00:00:00

abstract：:This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on langua...

journal_title：Life sciences

authors： Normando VMF PhD,Dias ÁRN Me,da Silva ALSE Lic,da Silva Pinto D PhD,de Souza Santos MC PhD,Rodrigues CL Lic,de Oliveira EM PhD,de Souza Filho LEC Me,de Brito Vieira W Esp,Andriolo RB PhD,Sousa RCM PhD,Falcão LFM PhD,Quaresma JAS

更新日期：2020-09-01 00:00:00

abstract：:As soon as a pathogen invades through the physical barriers of its corresponding host, host mounts a series of protective immune response to get rid of the invading pathogen. Host's pattern recognition receptors (PRR), localized at the cellular surface, cytoplasm and also in the nucleus; recognises pathogen associated...

journal_title：Life sciences

authors： Rai RC

更新日期：2020-01-01 00:00:00

abstract：:The regulation of G protein-coupled receptor expression is important in the physiology of an organism and can occur at any of the steps between gene transcription to turnover of the receptor protein itself. Agonist stimulation causes receptor desensitization, which is characterized by a rapid reduction in response to ...

journal_title：Life sciences

authors： Heck DA,Bylund DB

更新日期：1998-01-01 00:00:00

abstract：:The effects of nineteen AHPA* derivatives were examined on morphine analgesia by tail-flick test in rats and on enkephalinase inhibition which was based on the formation of tyrosyl-glycyl-glycine from met-enkephalin. The correlation between the enhancement of morphine analgesia in vivo and enkephalinase inhibition in ...

journal_title：Life sciences

authors： Hachisu M,Nakamura T,Kawashima H,Shitoh K,Fukatsu S,Koeda T,Sekizawa Y,Munakata M,Kawamura K,Umezawa H,Takeuchi T,Aoyagi T

更新日期：1982-05-17 00:00:00

abstract：AIMS:Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXRα) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the regulation of lipid metabolism and role of LX...

journal_title：Life sciences

authors： Jin P,Bian Y,Wang K,Cong G,Yan R,Sha Y,Ma X,Zhou J,Yuan Z,Jia S

更新日期：2018-12-01 00:00:00

abstract：AIMS:Sepsis is a major cause of morbidity and mortality in the elderly population. In prior studies, we have shown that in vivo, the inflammatory response in aged animals is exaggerated as compared to young animals and that this response likely accounts for the increased morbidity and mortality. Part of this uncontroll...

journal_title：Life sciences

authors： Leong J,Zhou M,Jacob A,Wang P

更新日期：2010-05-08 00:00:00

abstract：:We have previously reported that metronidazole treatment increases human lymphocyte proliferation showing individual differences. This drug and its metabolites are imidazole compounds like histamine and cimetidine. The first is an endogenous amine that inhibits T-helper lymphocyte proliferation, and the second is a hi...

journal_title：Life sciences

authors： Elizondo G,Ostrosky-Wegman P

更新日期：1996-01-01 00:00:00

abstract：:Central administration of the selective mu opioid agonist, dermorphin, produces a concurrent diuretic and antinatriuretic response in conscious rats. To determine whether central mu opioids differentially affect the renal excretion of water and sodium, we examined changes in renal function produced by intracerebrovent...

journal_title：Life sciences

authors： Kapusta DR,Dzialowski EM

更新日期：1995-01-01 00:00:00

abstract：:In order to determine the effect of relaxin and estradiol on collagen and noncollagen synthesis by mammary gland fibroblasts, fibroblasts isolated from guinea pig mammary glands were grown on plastic or Cytodex-3 collagen coated microcarriers. On plastic, estradiol (600 pg/ml) increased the incorporation of tritiated ...

journal_title：Life sciences

authors： Sheffield LG,Anderson RR

更新日期：1984-11-26 00:00:00

abstract：:The effects of porcine uterine fluid filtrate (PUF) on lymphocyte activity were examined. PUF was added to porcine lymphocyte cultures in the presence or absence of phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM). Lymphocyte response was determined by 3H-thymidine incorporation. Results ind...

journal_title：Life sciences

authors： Li WI,Yang WC

更新日期：1993-01-01 00:00:00

abstract：:Aromatase transforms irreversibly androgens into estrogens and is present in the endoplasmic reticulum of various tissues including the mammalian testis. In rat all testicular cells except peritubular cells express aromatase. Indeed in adult rat germ cells (pachytene spermatocytes and round spermatids) we have demonst...

journal_title：Life sciences

authors： Carreau S,Bois C,Zanatta L,Silva FR,Bouraima-Lelong H,Delalande C

更新日期：2011-10-10 00:00:00

abstract：OBJECTIVE:We aimed to explore the expression level and biological function of miR-145-5p in preeclampsia (PE). METHODS:The differentially expressed miRNA/mRNA between normal placentas and PE placentas were screened using the GSE84260 and GSE73374 datasets from the Gene Expression Omnibus Database. The expression of mi...

journal_title：Life sciences

authors： Lv Y,Lu X,Li C,Fan Y,Ji X,Long W,Meng L,Wu L,Wang L,Lv M,Ding H

更新日期：2019-12-15 00:00:00

abstract：AIM:The aim of this study was to investigate the effect of protolichesterinic acid, a lichen secondary metabolite, on anti-proliferative activity of doxorubicin in three human cancer cell lines, HeLa, SH-SY5Y and K562 cells. MAIN METHODS:The data obtained from MTT assays, performed on cells treated with protolichester...

journal_title：Life sciences

authors： Brisdelli F,Perilli M,Sellitri D,Bellio P,Bozzi A,Amicosante G,Nicoletti M,Piovano M,Celenza G

更新日期：2016-08-01 00:00:00

abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...

journal_title：Life sciences

authors： Matsuda H,Li Y,Yoshikawa M

更新日期：1999-01-01 00:00:00

abstract：:The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus in vitro has been investigated. Of the compounds tested, only trans-[(NO)(P(OEt)3)(NH3)4Ru](PF6)3 (1-2.5 mM) exerted a strong facilitatory action on the population spik...

journal_title：Life sciences

authors： Wieraszko A,Clarke MJ,Lang DR,Lopes LG,Franco DW

更新日期：2001-02-16 00:00:00

abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...

journal_title：Life sciences

authors： Sandrini M,Vitale G,Vergoni AV,Ottani A,Bertolini A

更新日期：1997-01-01 00:00:00

abstract：AIMS:Ischemia/reperfusion injury (IRI), resulting from hypoxic damage within a graft, is the leading cause of cell death and graft rejection. In this study, we investigated whether a HIF-1α inhibitor or various antioxidants were able to prevent ischemic injury in a cellular model in which experimental hypoxia was induc...

journal_title：Life sciences

authors： Song H,Han IY,Kim Y,Kim YH,Choi IW,Seo SK,Jung SY,Park S,Kang MS

更新日期：2015-04-01 00:00:00

abstract：AIMS:Peptides and a dysregulated immune system play a role in the pathophysiology of autism. Dysfunctions in prolyl endopeptidase (PEP) and dipeptidyl peptidase IV (DPP-IV) may underpin both the peptidergic and immune alterations in autism. The aims of this study are to: (i) delineate serum PEP and DPP-IV enzyme activi...

journal_title：Life sciences

authors： Frenssen F,Croonenberghs J,Van den Steene H,Maes M

更新日期：2015-09-01 00:00:00

abstract：:In vivo benzodiazepine receptor binding has generally been studied by "ex vivo" techniques. In this investigation, we identify the conditions where [3H]-Ro 15-1788 labels benzodiazepine receptors by true "in vivo" binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homoge...

journal_title：Life sciences

authors： Goeders NE,Kuhar MJ

更新日期：1985-07-29 00:00:00

abstract：:Previous research in this laboratory has shown that chronic treatment of adult male rats with an anabolic-androgenic steroid (AAS) produced anxiolytic behavior and increased the functional response of cortical gamma-aminobutyric acid(A) (GABA(A)) receptors. The experiments reported here were aimed at further character...

journal_title：Life sciences

authors： Bitran D,Hilvers RJ,Frye CA,Erskine MS

更新日期：1996-01-01 00:00:00

abstract：:Responses to synthetic human adrenomedullin, a novel hypotensive peptide localized in several organ systems, including the lung, and the carboxy terminal 15-52 amino acid fragment of adrenomedullin (ADM15-52) were investigated in the pulmonary vascular bed of the intact-chest cat. Under constant flow conditions when b...

journal_title：Life sciences

authors： Cheng DY,DeWitt BJ,Wegmann MJ,Coy DH,Bitar K,Murphy WA,Kadowitz PJ

更新日期：1994-01-01 00:00:00

abstract：:Circadian rhythms might be involved in addictive behaviors. The pineal secretory product melatonin decreases cocaine sensitization in rats; mice mutant for the critical melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase (AANAT), exhibit altered behaviors. We hypothesized that AANAT/melatonin system, whi...

journal_title：Life sciences

authors： Uz T,Javaid JI,Manev H

更新日期：2002-05-10 00:00:00

abstract：AIMS:Cerebral atrophy resulting from neurodegeneration is highly prevalent in individuals with diabetes; however, the underlying mechanisms for diabetic neurodegeneration are not fully understood. Here we hypothesized that hyperglycemia induces molecular signaling that favors induction of proliferation in post mitotic,...

journal_title：Life sciences

authors： Yang E,Gavini K,Bhakta A,Dhanasekaran M,Khan I,Parameshwaran K

更新日期：2018-07-15 00:00:00

abstract：:The effect of polyamines on the catalytic domain of protein kinase C from rat brain was investigated. It was found that the addition of spermine strongly inhibited phosphorylation activity toward histone H1 as substrate. This tetramine, at millimolar concentrations, was most potently effective while triamines and diam...

journal_title：Life sciences

authors： Mezzetti G,Monti MG,Moruzzi MS

更新日期：1988-01-01 00:00:00

abstract：AIMS:There have been recent reports that reconsolidation-based interventions attenuate drug reward memories in rodents. The insular cortex (IC) is an essential part of neural circuits that underlie cue-drug memory reconsolidation. GABAergic interneurons in the IC are a potent control on network excitability and play an...

journal_title：Life sciences

authors： Sun K,Xiao L,Wu Y,Zuo D,Zhang C,Liu S,He Z,Rong S,Wang F,Sun T

更新日期：2020-08-01 00:00:00

abstract：:Glial cells are currently viewed as active partners of neurons in synapse formation. The close proximity of astrocytes to the synaptic cleft implicates that they strongly influence synapse function as well as suggests that these cells might be potential targets for neuronal-released molecules. In this review, we discu...

journal_title：Life sciences

authors： Stipursky J,Romão L,Tortelli V,Neto VM,Gomes FC

更新日期：2011-10-10 00:00:00

abstract：:Previous behavioral studies on triazolam (TZ), which are small in number, could only speculate about tolerance to the anxiolytic effect of TZ, as the experiments did not cover sufficient time (of 4 to 7 days) for tolerance to develop. Therefore longer time for chronic TZ administration is used. We investigated the eff...

journal_title：Life sciences

authors： Aburawi SM,Elhwuegi AS,Ahmed SS,Saad SF,Attia AS

更新日期：2003-10-31 00:00:00

abstract：AIMS:Toll-like receptor (TLR)9 ligand CpG-oligodeoxynucleotide (CpG-ODN) exerts preconditioning in myocardial ischemia/reperfusion. We hypothesized a postconditioning effect of CpG-ODN in a murine closed-chest model of myocardial infarction. MATERIALS AND METHODS:C57BL/6 (12 weeks, male, WT) mice were instrumented at ...

journal_title：Life sciences

authors： Kim SC,Wu S,Fang X,Neumann J,Eichhorn L,Schleifer G,Boehm O,Meyer R,Frede S,Hoeft A,Baumgarten G,Knuefermann P

更新日期：2014-12-05 00:00:00

abstract：:The optical isomers of apomorphine (APO) and N-propylnorapomorphine (NPA) were interacted with three biochemical indices of dopamine (DA) receptors in extrapyramidal and limbic preparations of rat brain tissue. There were consistent isomeric preferences for the R(-) configuration of both DA analogs in stimulating aden...

journal_title：Life sciences

authors： Kula NS,Baldessarini RJ,Bromley S,Neumeyer JL

更新日期：1985-09-16 00:00:00