Abstract：
:Central administration of the selective mu opioid agonist, dermorphin, produces a concurrent diuretic and antinatriuretic response in conscious rats. To determine whether central mu opioids differentially affect the renal excretion of water and sodium, we examined changes in renal function produced by intracerebroventricular (i.c.v.) administration of dermorphin during continuous intravenous (i.v.) infusion of a synthetic ADH analogue in conscious Sprague-Dawley rats. During ADH infusion the typical diuresis produced by i.c.v. dermorphin was abolished although the antinatriuresis remained intact. Alone, i.v. ADH produced a decrease in urine flow rate without significantly altering urinary sodium excretion. In other studies, the effects of i.c.v. dermorphin were examined on the renal responses produced by i.v. infusion of a V2-ADH receptor antagonist. In these studies the magnitude of the V2 antagonist-induced diuresis was not altered by i.c.v. dermorphin but the increase in urinary sodium excretion produced by this antagonist was converted to an antinatriuresis. Central dermorphin did not alter heart rate or mean arterial pressure in either study. These findings suggest that the effects of central dermorphin on renal sodium and water handling are mediated by separate mechanisms; the effects on water involving changes in circulating ADH levels and the effects on sodium independent of the action of this hormone.
journal_name
Life Scijournal_title
Life sciencesauthors
Kapusta DR,Dzialowski EMdoi
10.1016/0024-3205(95)00065-esubject
Has Abstractpub_date
1995-01-01 00:00:00pages
PL243-8issue
14eissn
0024-3205issn
1879-0631pii
002432059500065Ejournal_volume
56pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Formation of etretinate, ethyl ester of acitretin, can be confirmed in vitro and in vivo using acitretin as the substrate. Etretinate was identified by LC/MS. The in vitro incubation was performed using rat and human liver 12,000 g supernatant, and the in vivo experiment was conducted in rats after oral dosing of acit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90332-6
更新日期：1991-01-01 00:00:00
abstract：:Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-NG-nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reve...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90102-h
更新日期：1991-01-01 00:00:00
abstract：:The human placental villus tissue contains opioid receptors and peptides. The opioid peptides extracted from the villus tissue were fractionated using reverse-phase high performance liquid chromatography and a radio-receptor assay. The presence of dynorphin 1-8 was corroborated by mass spectrometric production of (M +...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90099-3
更新日期：1987-05-25 00:00:00
abstract：AIMS:Individual susceptibility to develop obesity may impact the development of cardio-metabolic risk factors that lead to obesity-related comorbid conditions. Obesity-prone Osborne-Mendel (OM) rats expressed higher levels of visceral adipose inflammation than obesity-resistant, S5B/Pl (S5B) rats. However, the consumpt...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.022
更新日期：2019-04-15 00:00:00
abstract：:The effects of unilateral intracarotid administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in sheep were studied with the goal of producing a non-primate, large animal model of Parkinson's Disease. Adult female sheep were given an acute (over 30 min) or chronic (over 1 week) injection of MPTP (0.4-5....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00406-4
更新日期：1994-01-01 00:00:00
abstract：:Nitrosamines are carcinogens formed in the mammalian organism from amine precursors contained in food, beverages, cosmetics and drugs. The potent carcinogen, NNK, and the weaker carcinogen, NNN, are nitrosamines formed from nicotine. Metabolites of the nitrosamines react with DNA to form adducts responsible for genoto...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2007.03.006
更新日期：2007-05-30 00:00:00
abstract：:Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding sites on rat brain synaptosomes, with a potency intermediate to other benzodiazepines (BDZs), and Hill coefficients near 1 in different brain regions. Incubation at 37 degrees C reduced prem...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90646-5
更新日期：1984-07-23 00:00:00
abstract：:Species-related specific differences in the pharmacological profile of vasopressin V1a receptors have been reported. Thus, the aim of the present study was to identify a vascular preparation of human origin expressing V1a receptors. Vasopressin was found to contract human gastric artery strips without endothelium with...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00635-2
更新日期：1997-01-01 00:00:00
abstract：:This study was conducted to investigate SAFB-induced apoptosis of mast cells as it pertains to both its basic drug mechanism and the potential therapeutics of the pathologic conditions accompanying mast cell proliferation. SAFB induced many apoptotic manifestations as evidenced by changes in cell morphology, generatio...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01140-7
更新日期：2001-06-22 00:00:00
abstract：:In the present report we describe an NTPDase 1 (ATP diphosphohydrolase; ecto-apyrase; EC 3.6.1.5) in rat hippocampal slices. The effect of glutamate on the ATPase and ADPase activities in rat hippocampal slices of different ages was also studied since adenosine, the final product of an enzymatic chain that includes NT...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01621-1
更新日期：2002-05-31 00:00:00
abstract：:Cardiovascular effects of the essential oil of Croton zehntneri (EOCZ) were investigated in conscious rats. In these preparations, intravenous (i.v.) injections of EOCZ (1-20 mg kg(-1)) and its main constituents anethole and estragole (both at 1-10 mg kg(-1)) elicited brief and dose-dependent hypotension and bradycard...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.09.042
更新日期：2006-04-11 00:00:00
abstract：AIMS:Histone modifications play central epigenetic roles in regulating the entire genome of the cell and cell proliferation. Herein, we investigated the effects of the natural compound, 16-hydroxycleroda-3,13-dien-15,16-olide (PL3), on the expressions of histone-modifying enzymes, and examined how it induces apoptosis ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.09.011
更新日期：2011-12-05 00:00:00
abstract：:Peroxisome proliferator-activated receptor (PPAR) and retinoid x receptor (RXR) play important roles in fatty acid metabolism. The present study examined the regulation of retinoic acid receptor (RAR alpha, beta, and gamma), RXR (alpha, beta, and gamma), PPAR, cytochrome P450 2E1 (CYP2E1), catalase, and beta-actin gen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00953-8
更新日期：1995-01-01 00:00:00
abstract：:The pigeon crop-sac is a well-known target organ of prolactin (PRL). Pukac and Horseman (Endocrinology 114: 1718, 1984) reported that injections of the hormone caused changes in the expression of several specific proteins in that organ. We investigated the possibility that measuring the amounts of three of these prote...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90532-t
更新日期：1992-01-01 00:00:00
abstract：:Extracts of increasing polarity of 6 Venezuelan plants belonging to the Chrysobalanaceae family were tested for possible letal toxicity against Biomphalaria glabrata Say, a snail intermediate hosts of Schistosoma mansoni Sambon. The piscicidal toxicity of the active extracts was also evaluated with the aim of findings...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00600-1
更新日期：2000-01-01 00:00:00
abstract：:Methotrexate was found to stimulate asparagine synthetase activity in vivo by approximately six-fold in rat liver. The maximum effect of methotrexate on hepatic asparagine synthetase activity was observed sixteen hours after intraperitoneal injection of the drug. Cycloheximide, like methotrexate, is a protein synthesi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90524-0
更新日期：1982-03-22 00:00:00
abstract：AIMS:Hypoxia makes cells death but it is not always true. Short term anoxia can boost remaining cells activities and promote tissue repair. This study is to explore the effects of hypoxic preconditioning (HP) on osteoblasts and analyze the involved lncRNA and mRNA. MAIN METHODS:Human osteoblast was used. Normoxic cont...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.07.014
更新日期：2018-09-01 00:00:00
abstract：:Previous studies have indicated that one of the causes of alveolar bone destruction with periodontitis is lipopolysaccharide (LPS) from the cell wall of gram-negative bacteria in plaque, and that prostaglandin E(2) (PGE(2)) is one of the bone resorption factors that stimulate osteoclast formation through an intercellu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.09.019
更新日期：2006-03-20 00:00:00
abstract：AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118833
更新日期：2021-01-15 00:00:00
abstract：:Groups of 35-day-old male C57BL/6 mice were stressed 1 hour per day by immobilization for 1, 2, 3, 5, 8, 11 or 14 consecutive days. Control groups were left undisturbed. The animals were then killed and body weight and the weights of the thymus, spleen and axillary lymph nodes determined. Chronic immobilization stress...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00606-1
更新日期：1997-01-01 00:00:00
abstract：AIMS:Previous studies have shown that isorhamnetin has anti-adipogenic effects in mouse 3T3-L1 cells. This study was conducted to elucidate the inhibitory mechanisms of isorhamnetin during adipogenic differentiation of human adipose tissue-derived stem cells (hAMSCs). MAIN METHODS:The effect of isorhamnetin on adipoge...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.01.012
更新日期：2010-03-13 00:00:00
abstract：:Overexpression of vascular endothelial growth factor (VEGF) and the extent of neoangiogenesis are closely correlated with tumor development and cancer metastases. To assess whether VEGF mediated angiogenesis is regulated by HDM2, we treated the GI-101A and HL-60 cells with HDM2 gene specific antisense phosphorothioate...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.04.004
更新日期：2008-06-20 00:00:00
abstract：:Aim Deformity in the cellular homeostatic event associated with cell survival and apoptosis are committing factors for carcinogenesis. Interventions of these events by pharmacologically active agent gain predominance in cancer treatment. In current investigation Solanidine, a steroidal alkaloid was evaluated on tumori...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.03.015
更新日期：2018-04-15 00:00:00
abstract：:The effect of local pH on the in vivo efflux of endogenous dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) following administration of d-amphetamine (AMPH) was examined in the striatum of the anesthetized rat using two bilaterally placed push-pull cannulae. At both pH 7.3 and 6.4, the baseline efflux values f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90332-3
更新日期：1988-01-01 00:00:00
abstract：:Ornithine decarboxylase (ODC) activity increases during many growth responses. Some cells and tissues in culture also exhibit elevated enzyme activity with decreasing osmolality of the culture medium. We have found that this also occurs with uterine tissue from ovariectomized rats. Organ culture incubation under hypot...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90551-4
更新日期：1984-03-26 00:00:00
abstract：:The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.06.013
更新日期：2008-08-15 00:00:00
abstract：:Retinoids have been shown the most powerful inducers of transglutaminase activity, a well known marker of differentiation. In this work, we tested the effects of all-trans retinoic acid and EGF, used alone or in combination, on transglutaminase activity in a squamous, epithelial carcinoma cell line, HEp-2. We demonstr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.04.047
更新日期：2004-10-15 00:00:00
abstract：:Phencyclidine hydrochloride (PCP) was tested for its ability to alter a variety of immune effector and regulatory functions in vitro. B6C3F1 murine splenic lymphocytes or elicited peritoneal macrophages were cultured in vitro with medium only or medium containing 10(-10)-10(-4) M PCP. Macrophages cultured with or with...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90584-p
更新日期：1993-01-01 00:00:00
abstract：:It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00160-x
更新日期：1998-01-01 00:00:00
abstract：:Stimulation of the preganglionic trunk of the ipsilateral superior cervical sympathetic ganglion with square wave electrical pulses produced secretion from the main excretory duct of the rabbit lacrimal gland. The secretion was inhibited by propranolol (1 mg/kg) and metoprolol (10 mg/kg) but not by phenoxybenzamine (2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90424-7
更新日期：1984-06-11 00:00:00
