Stimulation of uterine ornithine decarboxylase in organ culture by decreasing osmolality: possible relation to in vivo mechanisms.

abstract：:SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approa...

journal_title：Life sciences

authors： Wang SC,Wang YF

更新日期：2021-01-26 00:00:00

abstract：:Comparison of neuronal and non-neuronal membrane transport of, and neuroexcitation by, the dicarboxylic amino acids bring out provocative similarities in structural selectivity, and hence in the strategies for studying them. Parallel anomalies in stereoselectivity show for both phenomena that the recognition sites are...

journal_title：Life sciences

authors： Christensen HN,Makowske M

更新日期：1983-12-05 00:00:00

abstract：AIM:To evaluate the therapeutic efficacy of hypoxic cell-sensitizer Sanazole (SAN) -directed targeting of cytotoxic drug Berberine (BBN) and Iron-oxide nanoparticle (NP) complexes, to solid tumor in Swiss albino mice. MAIN METHODS:NP-BBN-SAN complexes were characterized by FTIR, XRD, TEM and Nano-size analyzer. This c...

journal_title：Life sciences

authors： Sreeja S,Krishnan Nair CK

更新日期：2018-02-15 00:00:00

abstract：:The prototypic arylpiperazines, meta-chlorophenylpiperazine (mCPP), meta-trifluoromethylphenylpiperazine (TFMPP) and quipazine are widely studied serotonergic ligands with nonselective effects at 5HT1 and 5HT2 receptor subtypes. The present study was designed to compare the affinities of these arylipiperazines at 5HT3...

journal_title：Life sciences

authors： Robertson DW,Bloomquist W,Wong DT,Cohen ML

更新日期：1992-01-01 00:00:00

abstract：:Virgin, male Sprague-Dawley rats were used to study the production of cardiac failure by a single subcutaneous injection of 85 mg/kg dl-isoproterenol (ISO) and the possible preservation of cardiac function by a pre-treatment of 50 mg/kg verapamil (VER) 5 min prior to 85 mg/kg ISO. At 24 hrs after drug injections cardi...

journal_title：Life sciences

authors： Yeager JC,Whitehurst ME

更新日期：1982-01-18 00:00:00

abstract：:Leu-enkephalin (100 micrograms/kg, i.p.) administered to mice 5 min before training in a one way active avoidance task significantly reduced the number of avoidances observed in the peptide treated animals. This impairing action of Leu-enkephalin was partially attenuated by methylnaloxonium (naloxonium), a quarternary...

journal_title：Life sciences

authors： Martinez JL Jr,de Graaf JS,Chavkin C,Dana RC

更新日期：1985-12-23 00:00:00

abstract：:The effects of GABA antagonists, picrotoxin and bicuculline were studied on hyperphagia caused by insulin in free feeding rats. It was found that peripheral administration of GABA antagonists inhibited this hyperphagia. These agents were administered in the VMH and LH through stereotaxically implanted cannulae. It was...

journal_title：Life sciences

authors： Kamatchi GL,Bhakthavatsalam P,Chandra D,Bapna JS

更新日期：1984-06-04 00:00:00

abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...

journal_title：Life sciences

authors： Sandrini M,Vitale G,Vergoni AV,Ottani A,Bertolini A

更新日期：1997-01-01 00:00:00

abstract：:The effects of three local anesthetics, lidocaine, dibucaine, and tetracaine, on Na+/H+ antiporter activity were examined in brush border membrane-reconstituted vesicles. Lidocaine at 10 microM inhibited H+ efflux in the presence of an inward Na+ gradient, suggesting that this anesthetic specifically inhibits the Na+/...

journal_title：Life sciences

authors： Shibamoto S,Hori T,Hayakawa M,Nango M,Cragoe EJ Jr,Oku N,Ito F

更新日期：1990-01-01 00:00:00

abstract：:Acute myocardial infarction is associated with high rates of morbidity and mortality and can cause irreversible myocardial damage. Timely reperfusion is critical to limit infarct size and salvage the ischemic myocardium. However, reperfusion may exacerbate lethal tissue injury, a phenomenon known as myocardial ischemi...

journal_title：Life sciences

authors： Wu Y,Liu H,Wang X

更新日期：2021-01-01 00:00:00

abstract：:The vascular endothelium is recognized as a barrier between blood and blood vessel wall. The abnormality of vascular endothelium is critical for atherosclerosis, hypertension and diabetes. Oxidative stress, inflammation, obesity, hyperlipidemia and insulin resistance are major contributors to endothelial dysfunction i...

journal_title：Life sciences

authors： Sun HJ,Hou B,Wang X,Zhu XX,Li KX,Qiu LY

更新日期：2016-12-15 00:00:00

abstract：:The present study was undertaken to examine whether there was a time-dependent change in the toxic effects of amikacin, an aminoglycoside, on renal functions. Male Wistar rats were maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Amikacin (1.2 g/kg) was injected intraperitoneally to a...

journal_title：Life sciences

authors： Fujimura A,Sudoh T,Ebihara A

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To investigate the protective efficacies and potent mechanisms of combination therapy with semaglutide and rosiglitazone (RSG) on the high-glucose incubated human ARPE-19 cells and diabetic retinopathy (DR) model rats. MAIN METHODS:The CCK-8 methods were used to evaluate the protective effects of semaglutide...

journal_title：Life sciences

authors： Yang X,Wu S,Feng Z,Yi G,Zheng Y,Xia Z

更新日期：2021-01-05 00:00:00

abstract：:Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated hypercholesterolemia. To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced ...

journal_title：Life sciences

authors： Sakuma Y,Hagihara H,Nagayoshi A,Ohne K,Mutoh S,Ito Y,Nakahara K,Notsu Y,Okuhara M

更新日期：1997-01-01 00:00:00

abstract：:In human tumors changes in angiogenesis and expression of extracellular matrix-degrading enzymes occur simultaneously during invasion and metastasis. Tissues from 20 biopsies of human neuroblastoma (NB) were investigated immunohistochemically by using an antibody against factor VIII to determine their microvessel numb...

journal_title：Life sciences

authors： Ribatti D,Surico G,Vacca A,De Leonardis F,Lastilla G,Montaldo PG,Rigillo N,Ponzoni M

更新日期：2001-01-26 00:00:00

abstract：:The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO a...

journal_title：Life sciences

authors： Chaillet P,Coulaud A,Fournié-Zaluski MC,Gacel G,Roques BP,Costentin J

更新日期：1983-01-01 00:00:00

abstract：:Although the aging effect of dopamine D2 receptor in the striatum is well-documented, the effect of age on the extrastriatal dopamine D2 receptor has not been fully examined. Since the density of extrastriatal dopamine D2 receptor is very low, suitable ligands are limited. In this study, we used [11C]FLB 457 to quanti...

journal_title：Life sciences

authors： Inoue M,Suhara T,Sudo Y,Okubo Y,Yasuno F,Kishimoto T,Yoshikawa K,Tanada S

更新日期：2001-07-20 00:00:00

abstract：:It has been suggested that the myocardial production of nitric oxide, as a consequence of expression of the inducible isoform of nitric oxide synthase (NOS), plays an important role in the pathophysiology of heart failure. We determined the net cardiac production of nitrogen oxides (NOx), as a measure of NOS activity,...

journal_title：Life sciences

authors： Kaye DM,Chin-Dusting J,Esler MD,Jennings GL

更新日期：1998-01-01 00:00:00

abstract：AIMS:The present work evaluated the anti-inflammatory/antioxidant activity of a well characterized extract from Citrus bergamia Risso and Poiteau (CBE), containing neoeriocitrin, naringin, neohesperidin and other flavonoids, on human NCTC 2544 keratinocytes treated with interferon-gamma (IFN-γ) and histamine (H). MAIN...

journal_title：Life sciences

authors： Graziano AC,Cardile V,Crascì L,Caggia S,Dugo P,Bonina F,Panico A

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00

abstract：AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...

journal_title：Life sciences

authors： Li B,Huang Q,Lin C,Lu R,Wang T,Chen X,Liu Z,Liu Y,Wu J,Wu Y,Liao S,Ding X

更新日期：2021-01-15 00:00:00

abstract：AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...

journal_title：Life sciences

authors： Kumar R,Yadav A,Pakrasi PL

更新日期：2017-02-01 00:00:00

abstract：:We reported recently that ventromedial hypothalamic (VMH) lesions increased the synthesis of DNA in the gastrointestinal tract of rats by the firing of vagus nerve activity, mainly via cholinergic receptor mechanisms. In the present study, we examined whether the mitotic response is due to proliferation of a cell popu...

journal_title：Life sciences

authors： Kiba T,Tanaka K,Hoshino M,Numata K,Okano K,Inoue S

更新日期：1995-01-01 00:00:00

abstract：:It has been previously shown in anesthetized pigs that intravenous infusion of 2 microg/h of 17beta-estradiol primarily dilated renal, iliac and coronary circulations, while higher doses of the hormone were required to cause vasodilation also in the mesenteric vascular bed. In the same experimental model, a tonic beta...

journal_title：Life sciences

authors： Molinari C,Battaglia A,Grossini E,Mary DA,Surico N,Vacca G

更新日期：1999-01-01 00:00:00

abstract：:N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. The mechanism of NOS inhibition by L-NAME is uncertain. L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). Concommitantly, L-NAME was hydrolyzed, non-enzymatically, to N(G)-Nitro-L-a...

journal_title：Life sciences

authors： Furfine ES,Carbine K,Bunker S,Tanoury G,Harmon M,Laubach V,Sherman P

更新日期：1997-01-01 00:00:00

abstract：:Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val, melanin concentrating hormone (MCH), is a cyclic hormone possessing both MCH-like (melanin granule aggregating effect) and melanocyte stimulating hormone (MSH)-like (melanin granule dispersing effect) activities. Nine ring-contracted analogues were s...

journal_title：Life sciences

authors： Lebl M,Hruby VJ,Castrucci AM,Hadley ME

更新日期：1989-01-01 00:00:00

abstract：:Insulin resistance (IR) impairs endothelium-mediated vasodilation in cerebral arteries as well as K+ channel function in vascular smooth muscle. Peripheral arteries also show an impaired endothelium-dependent vasodilation in IR and concomitantly show an enhanced contractile response to endothelin-1 (ET-1). However, th...

journal_title：Life sciences

authors： Simandle SA,Erdös B,Snipes JA,Miller AW,Busija DW

更新日期：2005-09-16 00:00:00

abstract：:We studied the effects of cAMP on cytokine (interferon-gamma plus tumor necrosis factor-alpha)-induced stimulation of tetrahydrobiopterin (BH4) synthesis in human umbilical vein endothelial cells (HUVEC). The cytokine mixture caused a marked increase in the biosynthesis and release of BH4 by HUVEC. Dibutyryl-cAMP prod...

journal_title：Life sciences

authors： Ohtsuki M,Shiraishi H,Kato T,Kuroda R,Tazawa M,Sumi-Ichinose C,Tada S,Udagawa Y,Itoh M,Hishida H,Ichinose H,Nagatsu T,Hagino Y,Nomura T

更新日期：2002-03-22 00:00:00

abstract：:Neuron specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase, has been established by immunocytochemical means as a marker of morphological and functional maturation in central neurons and appears late in development. However, little is known about the presence of NSE in developing peripheral neurons a...

journal_title：Life sciences

authors： Sheppard MN,Marangos PJ,Bloom SR,Polak JM

更新日期：1984-01-16 00:00:00

abstract：:The structure of a new crystal form of leucine-enkephalin has been determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and both have extended peptide backbone conformations with side-chains arranged alternately above and below the backbone planes. The two pentapeptides are hydro...

journal_title：Life sciences

authors： Mastropaolo D,Camerman A,Ma LY,Camerman N

更新日期：1987-05-18 00:00:00