Abstract:
:It has been suggested that the myocardial production of nitric oxide, as a consequence of expression of the inducible isoform of nitric oxide synthase (NOS), plays an important role in the pathophysiology of heart failure. We determined the net cardiac production of nitrogen oxides (NOx), as a measure of NOS activity, by performing arterial and coronary sinus sampling in healthy control subjects (n=6) and patients with end-stage heart failure (n=10). The arterial plasma NOx concentration was significantly elevated in heart failure patients (58.4 +/- 7.0 vs 36.9 +/- 4.9 microM, p<0.05). However, we found net extraction of NOx across the heart, with no difference between the two groups. Therefore, the heart does not appear to be a source of NOx in heart failure, and this study does not support a pathophysiological role for NOx in this condition.
journal_name
Life Scijournal_title
Life sciencesauthors
Kaye DM,Chin-Dusting J,Esler MD,Jennings GLdoi
10.1016/s0024-3205(98)00005-8subject
Has Abstractpub_date
1998-01-01 00:00:00pages
883-7issue
10eissn
0024-3205issn
1879-0631pii
S0024320598000058journal_volume
62pub_type
临床试验,杂志文章相关文献
LIFE SCIENCES文献大全abstract::Despite the considerable number of published studies in the field of S-nitrosothiols (RSNO), the determination of these compounds in biological samples still represents an analytical challenge, due to several technical obstacles and often long sample preparation procedures. Other problems derive from the intrinsic lab...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2010.10.024
更新日期:2011-01-17 00:00:00
abstract::Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. MCP-1 is found in macrophage-rich areas of atherosclerotic lesions. Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.06.019
更新日期:2007-07-26 00:00:00
abstract::Liver fibrosis is a global health issue that causes morbidity and mortality with no currently available treatment. It has been shown that low dose paclitaxel (PTX) can stabilize microtubules and inhibit the profibrotic transforming growth factor-beta 1 (TGF-β1) signaling pathway. In this study the effect of treatment ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.09.037
更新日期:2018-10-15 00:00:00
abstract::The effect of prior incubation with a single concentration of isoproterenol (10(-4) M) for 2 hours at 37 degrees C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subjects groups prior incubation ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90277-7
更新日期:1984-10-22 00:00:00
abstract::Flavonoids from the leaves of Diospyros kaki L (FLDK-P70) are main therapeutic components of NaoXingQing, which is a novel and patented Traditional Chinese Medicine drug used for the treatment of syndrome of apoplexy for years in China. The present study investigated the effects of FLDK-P70 on hydrogen peroxide (H2O2)...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.09.031
更新日期:2005-03-11 00:00:00
abstract::Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2017.12.025
更新日期:2018-02-15 00:00:00
abstract::Although (-)-125I-iodopindolol (IPIN) can be used to label beta-adrenergic receptors in the central nervous system (CNS) in vivo, use of this ligand for receptor imaging studies in humans may be limited due to its relatively poor penetration into the CNS. A series of derivatives related to pindolol was therefore studi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90688-6
更新日期:1987-08-24 00:00:00
abstract::The purpose of the this study was to characterize the putative anxiolytic-like effects of the aqueous extract of Albizzia julibrissin stem bark using the elevated plus maze (EPM) in rats. The water extract of Albizzia julibrissin was orally administered at 10, 50, 100 or 200 mg/kg to adult male SD rats, 1 h before beh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.05.024
更新日期:2004-10-22 00:00:00
abstract::We compared the relative abilities of atropine sulfate and methylatropine, injected i.v. and into the cerebral ventricles (icv), to block pharmacological responses mediated through central and peripheral muscarinic receptors. The hypotensive response to i.v. injection of acetylcholine (peripheral muscarinic receptors)...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90389-x
更新日期:1988-01-01 00:00:00
abstract::Rats were given the basic lipophilic drug, phenoxybenzamine, in single i.v. doses of 0.4 and 30 mg/kg. The drug was determined in plasma and 7 tissues by a new HPLC method. Adipose tissue reached peak levels after 30 minutes. At that time levels in heart, kidney, and brain were higher than in subcutaneous, epididymal,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90478-4
更新日期:1987-10-26 00:00:00
abstract::Adenosine is a nucleoside which has been shown to participate in the regulation of physiological activity in a variety of mammalian tissues, and has been recognized as a homeostatic neuromodulator. It exerts its actions via membrane-bound receptors which have been characterized using biochemical, electrophysiological ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(91)90043-b
更新日期:1991-01-01 00:00:00
abstract:AIMS:Sarcopenia is characterized by muscle mass and strength loss and reduced physical activity. Branched-chain amino acids (BCAAs) were recently described as an activator of protein synthesis via mammalian target of rapamycin (mTOR) signaling for muscle atrophy. In cardiovascular diseases, excessive activation of the ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117593
更新日期:2020-06-01 00:00:00
abstract::Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118641
更新日期:2021-01-01 00:00:00
abstract::The potency of six antimuscarinic oxotremorine analogs at sympathetic ganglionic M1 and brainstem M2 muscarinic receptors was compared in the rat. Inhibition of the pressor effects of McNA343 or physostigmine was used as functional indicators of M1 and M2 blockade, respectively. 50% inhibitory doses (ID50) were calcul...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90442-t
更新日期:1990-01-01 00:00:00
abstract:AIMS:The aim of this study was to evaluate the antinociceptive (acute assays) and anti-inflammatory (chronic assays) effects of kramecyne (KACY), a peroxide isolated from Krameria cytisoides. MAIN METHODS:The antinociceptive activity of KACY was evaluated using the hot plate, acetic acid and formalin tests. The effect...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.11.015
更新日期:2015-01-15 00:00:00
abstract::Since many patients complain about halitosis without there being any clinical evidence of its cause, psychological symptoms have been pointed out as halitosis-inducing factors. The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC). Seventeen undergraduate m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.02.010
更新日期:2006-07-10 00:00:00
abstract::This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on langua...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117979
更新日期:2020-09-01 00:00:00
abstract::Mechanism of Nitric oxide (NO) production by ginsenosides was investigated in cultured porcine endothelial cells. Beta-nicotinamide adenine dinucleotide phosphate (beta-NADPH) staining showed that the NO production was significantly enhanced by the presence of 40 microg/ml ginsenosides with 10 microM L-arginine after ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00880-8
更新日期:2000-11-03 00:00:00
abstract::Ozone is a highly efficient disinfectant which may have significant advantages in water treatment compared to chlorine. It has, however, been shown that mutagenic and possibly carcinogenic byproducts may be produced under certain conditions of ozonation. Light chlorination following ozonization may meet the highest st...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(82)90643-9
更新日期:1982-01-11 00:00:00
abstract::Muscarinic agonists elicit contraction in the standard guinea pig ileum bioassay through activation of M3 muscarinic receptors that are also linked to phosphoinositide hydrolysis. Surprisingly, the most abundant muscarinic receptor in the ileum is the M2 which causes a specific inhibition of cyclic AMP accumulation el...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(94)00035-q
更新日期:1995-01-01 00:00:00
abstract::Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90930-x
更新日期:1983-02-28 00:00:00
abstract::5-Bromo-2'-deoxyuridine (BrdU) has been recently found to enhance adrenal glucocorticoid secretion in rats. Since BrdU-labeling is today the most employed technique for assessing cell proliferation, we have investigated whether this side-effect of BrdU may influence mitotic activity (as evaluated by metaphase-arrested...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00439-6
更新日期:1997-01-01 00:00:00
abstract:AIM:Exosomes, the nano-units (<200 nm), released from diverse cell types in the extracellular body fluid, possess non-immunogenic property and ability to cross the blood-brain barrier (BBB). Since exosomes carry biological information from their cells of origin, we hypothesize that priming cells with potential therapeu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.04.018
更新日期:2014-06-27 00:00:00
abstract:AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.11.009
更新日期:2009-01-16 00:00:00
abstract::Methodological shortcomings present in elicitation of male sexual reflexes in anesthetized animals. The present study has demonstrated, however, that intraperitoneal (i.p.) injection of p-chloroamphetamine (PCA), an indirect serotonin (5-HT) agonist, elicited simultaneously both penile erection and ejaculation in anes...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00895-x
更新日期:2000-11-10 00:00:00
abstract::We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90566-2
更新日期:1987-03-16 00:00:00
abstract::Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117994
更新日期:2020-09-15 00:00:00
abstract::Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90473-x
更新日期:1986-04-14 00:00:00
abstract::Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90092-1
更新日期:1989-01-01 00:00:00
abstract::The interactions of aminoglycoside, 3',4'-dideoxykanamycin B(DKB) with ATP and its related compounds were investigated. ATP, ADP, cyclic AMP and FAD bound to the DKB-conjugated Sepharose 4B column. The binding of DKB to ATP was also confirmed by equilibrium gel filtration. In the acidic pH region, the fluorescence of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90332-2
更新日期:1986-10-13 00:00:00