Abstract:
:Neuron specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase, has been established by immunocytochemical means as a marker of morphological and functional maturation in central neurons and appears late in development. However, little is known about the presence of NSE in developing peripheral neurons and endocrine cells and its relationship to the development of classical neurotransmitters and peptides. We therefore investigated the appearance of NSE immunoreactivity in nerves and mucosal endocrine cells of the human respiratory tract in foetal, neonatal and adult life. NSE was found to be present in neuroblasts, nerve fibres and endocrine cells from the earliest period of gestation examined (8 weeks), before the appearance of acetylcholinesterase activity (10-12 weeks), dopamine-beta-hydroxylase (20 weeks), vasoactive intestinal polypeptide (20 weeks) or calcitonin (20 weeks). Bombesin-like immunoreactivity was found in a small proportion of mucosal endocrine cells as early as eight weeks in the foetal respiratory tract. These findings indicate that unlike central neurons and their processes, peripheral neurons of the lung contain NSE immunoreactivity well before full maturation and establishment of synaptic contact with end organs.
journal_name
Life Scijournal_title
Life sciencesauthors
Sheppard MN,Marangos PJ,Bloom SR,Polak JMdoi
10.1016/0024-3205(84)90598-8subject
Has Abstractpub_date
1984-01-16 00:00:00pages
265-71issue
3eissn
0024-3205issn
1879-0631pii
0024-3205(84)90598-8journal_volume
34pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.09.001
更新日期:2016-11-01 00:00:00
abstract::Nitric oxide (NO) surprisingly caused the opposite effect on histamine and serotonin edema. The local injection of acidified nitrite (0.3-30 micrograms/paw which correspond 10 micrograms-1 mg/kg) increased histamine edema of mice up to 45 +/- 4% and suppressed serotonin edema to 90 +/- 3%. Other NO-generators (nitropr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90072-b
更新日期:1993-01-01 00:00:00
abstract::This study was undertaken to examine the receptor selectivity of Met-enkephalin-Arg6-Phe7 (MERF) employing radioreceptor binding assays in human cerebral cortex membranes, and to elucidate the responsible receptors that mediate the regulatory action of MERF on high (20 mM) K+-stimulated release of [3H]norepinephrine (...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00606-8
更新日期:2000-05-26 00:00:00
abstract:AIMS:Colorectal cancer (CRC) is one of the most common cancers with poor prognosis worldwide. The advent of immunotherapy has greatly improved survival in refractory patients of CRC. In this study, we aimed to identify reliable immune classification and biomarkers that predict immunotherapeutic responses in CRC patient...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118368
更新日期:2020-11-15 00:00:00
abstract::The effects of porcine uterine fluid filtrate (PUF) on lymphocyte activity were examined. PUF was added to porcine lymphocyte cultures in the presence or absence of phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM). Lymphocyte response was determined by 3H-thymidine incorporation. Results ind...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90290-j
更新日期:1993-01-01 00:00:00
abstract::Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy in preventing soman...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.04.071
更新日期:2005-11-26 00:00:00
abstract:AIMS:Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inf...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.08.064
更新日期:2018-10-01 00:00:00
abstract::Biological properties of homogeneous solutions of chicken (c) and mammalian (m) LHRH were compared by their ability to release LH, in vitro, from a rooster pituitary cell incubation system. Homogeneity of the two LHRH species was confirmed by High Performance Liquid Chromatography (HPLC) using linear gradients of acet...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90678-7
更新日期:1984-05-07 00:00:00
abstract::Significant labelled dopamine uptake was evident in bone marrow, spleen and lymph nodes of normal murine hosts in vivo. On the contrary animals bearing solid Ehrlich carcinoma, 3H-dopamine uptake was significantly reduced. The tumor tissue itself incorporated only insignificant amount of dopamine. Bone marrow cells, s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90645-j
更新日期:1993-01-01 00:00:00
abstract:AIMS:There have been recent reports that reconsolidation-based interventions attenuate drug reward memories in rodents. The insular cortex (IC) is an essential part of neural circuits that underlie cue-drug memory reconsolidation. GABAergic interneurons in the IC are a potent control on network excitability and play an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117655
更新日期:2020-08-01 00:00:00
abstract::We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00363-3
更新日期:1996-01-01 00:00:00
abstract::Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platf...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.01.047
更新日期:2019-04-01 00:00:00
abstract::Two male adult rhesus monkeys were used and caged individually. The room was temperature-controlled having a light-dark period of 12/12 hours. The animals were rapidly immobilized and immediately anesthetized with ketamine i. m. (10 mg/kg of body weight). They were bled four times at 15, 30, 45 and 60 mins after the k...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90247-9
更新日期:1991-01-01 00:00:00
abstract::In critically ill patients various conditions may lead to the activation of poly(ADP-ribose) polymerase (PARP). By promoting cellular energetic dysfunction, and by enhancing pro-inflammatory gene expression, PARP activation significantly contributes to the pathogenesis of shock. PARP activation is usually triggered by...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.11.001
更新日期:2008-01-16 00:00:00
abstract:UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01411-4
更新日期:2001-11-09 00:00:00
abstract::The gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa fro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.03.018
更新日期:2007-05-16 00:00:00
abstract::Concanavalin A enhanced the rat rectal absorption of phenol red and cefoxitin at pH 7.4 and the uptake of cefoxitin into brush border membrane vesicles prepared from rat rectal membrane. The enhancing action of concanavalin A demonstrated a sodium ion dependency and was inhibited by the presence of 4,4'-diisothiocyano...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90496-x
更新日期:1984-01-30 00:00:00
abstract::The herbal medicine, Echinacea, is used for treatment and prevention of upper respiratory tract infections. Among the phytochemicals found in Echinacea, the bioavailable alkylamides are thought to be the compounds responsible for its effects on the human immune system. Cytochrome P450 enzymes (P450s) appear to be the ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2009.04.023
更新日期:2009-07-17 00:00:00
abstract::1,25-dihydroxyvitamin D3 has important physiological effects such as calcium transport and cell growth and differentiation. These biological effects are mediated by their binding to specific intracellular receptor termed vitamin D receptor (VDR). VDR mRNA expression has been demonstrated in several tissues, but to dat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(96)00586-3
更新日期:1997-01-01 00:00:00
abstract::In this study, we determined the expression of protein kinase C (PKC) isoforms during pregnancy. At pregnant duration, PKC alpha was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00190-3
更新日期:1999-01-01 00:00:00
abstract::Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no de...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90346-0
更新日期:1982-09-20 00:00:00
abstract::Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90811-1
更新日期:1983-03-21 00:00:00
abstract::The impact of exposure to lead on gut cytokine gene expression and oral tolerance was analyzed. Oral tolerization with ovalbumin (OVA) increased levels of IL-10 and TGF-beta in gut tissue while IFN-gamma mRNA levels remained unchanged in both autoimmune diabetes prone NOD and normal C57BL/6 mice. This shift towards Th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00172-1
更新日期:1999-01-01 00:00:00
abstract:AIMS:Post-procedural myocardial necrosis manifested by elevated cardiac troponin T (cTnT) often complicates percutaneous coronary intervention (PCI). Plasma pentraxin 3 (PTX3) levels are increased in patients with arterial inflammation and especially unstable angina pectoris (UAP). This study tested whether plasma PTX3...
journal_title:Life sciences
pub_type: 临床试验,杂志文章
doi:10.1016/j.lfs.2013.11.021
更新日期:2014-01-24 00:00:00
abstract::We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related pept...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90618-8
更新日期:1989-01-01 00:00:00
abstract::The present study was undertaken to evaluate the cardioprotective potential of Curcuma longa (Turmeric) in the ischemia-reperfusion (I/R) model of myocardial infarction (MI). Wistar rats were divided into three groups and received saline orally (sham, control I/R group) and Curcuma longa 100 mg/kg (CL-100 treated grou...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.02.032
更新日期:2004-08-20 00:00:00
abstract::Rhesus monkeys were trained to discriminate injections of saline from those of beta-carboline-3-carboxylic acid ethyl ester (beta-CCE), a compound that binds to the benzodiazepine receptor, but often has actions opposite to those of the benzodiazepines. A benzodiazepine agonist midazolam and low doses of a specific be...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90240-7
更新日期:1986-03-17 00:00:00
abstract:AIMS:The dysregulation of circular RNAs (circRNAs) has been implicated in the progression of diabetic retinopathy (DR). This study aims to explore the role and underlying mechanism of hsa_circ_0081108 (circCOL1A2) in DR. MATERIALS AND METHODS:circCOL1A2, vascular endothelial growth factor (VEGF) and miR-29b expression...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117888
更新日期:2020-09-01 00:00:00
abstract::Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose (HG) environment, trigger mitochondrial stress by damaging mitochondrial DNA (mtDNA), altering inflammatory mediators, and neurodegener...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117914
更新日期:2020-09-01 00:00:00
abstract::Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90312-1
更新日期:1985-06-03 00:00:00