The gut cytokine balance as a target of lead toxicity.

abstract：:This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...

journal_title：Life sciences

authors： Dass PD

更新日期：1983-10-31 00:00:00

abstract：:The effects of cloricromene, a coumarine derivative, were studied in an anaesthetized rat model of coronary artery ligation (60 min) followed by reperfusion (60 min; MI/R). Sham operated rats were used as controls (Sham MI/R). Myocardial ischaemia-reperfusion injury produced a marked myocardial injury (necrotic area/a...

journal_title：Life sciences

authors： Squadrito F,Altavilla D,Zingarelli B,Ioculano M,Calapai G,Campo GM,Miceli A,Prosdocimi M,Caputi AP

更新日期：1993-01-01 00:00:00

abstract：:Normal mammary gland growth and reproduction were examined in C3H/HeMei mice given caffeine as drinking water (500 mg/l tap water) after weaning on day 20 of age. Caffeine ingestion had little effects on any of the day of vaginal opening, body growth, pattern of estrous cycles, mammary gland growth and reproduction ex...

journal_title：Life sciences

authors： Nagasawa H,Sakurai N

更新日期：1986-07-28 00:00:00

abstract：:In this study, we determined the expression of protein kinase C (PKC) isoforms during pregnancy. At pregnant duration, PKC alpha was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC...

journal_title：Life sciences

authors： Shyu JC,Hsieh YS,Chang CL,Tsai CC,Liu HC,Chang AC,Yang LC,Lin LY,Liu JY

更新日期：1999-01-01 00:00:00

abstract：:Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detected by metabolic labeling, Western blot analyses and immunofluorescence...

journal_title：Life sciences

authors： Forsman T,Lautala P,Lundström K,Monastyrskaia K,Ouzzine M,Burchell B,Taskinen J,Ulmanen I

更新日期：2000-10-06 00:00:00

abstract：:This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg0 at 6.6 to 7.5 mg/m3 for 4 hr each day for 3 consecutive days. This dosing protocol was lethal to o...

journal_title：Life sciences

authors： Yoshida M,Satoh M,Shimada A,Yasutake A,Sumi Y,Tohyama C

更新日期：1999-01-01 00:00:00

abstract：:The distribution of immunoreactive-dynorphin (ir-Dyn) in isolated subpopulations of bovine adrenal chromaffin cells was examined and compared with that of adrenaline (A), noradrenaline (NA) and ir-Leucine-Enkephalin (ir-Leu-Enk). Using a stepwise bovine serum albumin (BSA) gradient, various populations of catecholamin...

journal_title：Life sciences

authors： Dumont M,Day R,Lemaire S

更新日期：1983-01-17 00:00:00

abstract：:We investigated the effect of social isolation stress on the formation of experimental liver metastasis resulted from intraportal vein (i.p.v.) injection of colon 26-L5 carcinoma cells in male Balb/c mice, and elucidated some of the underlying mechanism involving the effects of this stress on cellular immunity. Increa...

journal_title：Life sciences

authors： Wu W,Yamaura T,Murakami K,Murata J,Matsumoto K,Watanabe H,Saiki I

更新日期：2000-03-31 00:00:00

abstract：:The sphincter of Oddi (SO) plays an important role in regulating the bile flow into the duodenum. This study was designed to investigate the effect of Chinese Medicinal Herbs Muh-Shiang-Bin-Lang-Wan (MSBLW) and their mechanism of action on regulating the motility of SO in rabbits. The activity of SO in anesthetized ra...

journal_title：Life sciences

authors： Kuo YI,Chiu JH,Lin JG,Hsieh CL,Wu CW

更新日期：2003-12-12 00:00:00

abstract：AIM:Although constitutive autophagy is linked to redox state and participates in cell homeostasis, it is scarcely known if redox state, autophagy, and lysosomal function depend on sex, a factor that largely influences health and diseases. Therefore, we evaluated the existence of sex differences in redox state and const...

journal_title：Life sciences

authors： Campesi I,Straface E,Occhioni S,Montella A,Franconi F

更新日期：2013-08-06 00:00:00

abstract：:Momordin II, a ribosome-inactivating protein from Momordica charantia seeds, was purified by a procedure involving a series of chromatographies on S-Sepharose, Sephadex G-50, CM-Sepharose, and Red Sepharose columns. Highly purified momordin II inhibited cell-free protein synthesis, released adenine from rat liver ribo...

journal_title：Life sciences

authors： Valbonesi P,Barbieri L,Bolognesi A,Bonora E,Polito L,Stirpe F

更新日期：1999-01-01 00:00:00

abstract：:The effects of isolation and water scheduling on mitogen induced lymphocyte proliferation were investigated. Isolated rats were animals which had been raised in group-housed conditions and then transferred to individual cages with ad lib access to water for a 1 or 2 week period. Water scheduled rats were maintained in...

journal_title：Life sciences

authors： Jessop JJ,Gale K,Bayer BM

更新日期：1988-01-01 00:00:00

abstract：:The metabolism of phosphoinositides plays an important role in the signal transduction pathways. We report here that naturally occurring polyamines affect the activities of phosphatidylinositol (PI) 3-kinase and PI 4-phosphate (PIP) 5-kinase differently. While polyamines inhibited the PI 3-kinase activity, they stimul...

journal_title：Life sciences

authors： Singh SS,Chauhan A,Brockerhoff H,Chauhan VP

更新日期：1995-01-01 00:00:00

abstract：AIMS:Benzodiazepines (BZDs) produce various pharmacological actions by binding to and allosterically regulating GABAA receptors. Several in vitro studies have demonstrated diazepam, the prototypic BZD, produces a high-dose action that cannot be countered with the classical BZD-binding site antagonist flumazenil. Here, ...

journal_title：Life sciences

authors： Cao Y,Yan H,Yu G,Su R

更新日期：2019-12-15 00:00:00

abstract：:Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circul...

journal_title：Life sciences

authors： Nakada T,Kwee IL

更新日期：1989-01-01 00:00:00

abstract：AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

journal_title：Life sciences

authors： Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

更新日期：2011-01-31 00:00:00

abstract：:The central interference induced by dexamethasone and RU-38486, (a glucocorticoid receptor antagonist) on morphine antinociception were studied by using the tail flick test in mice. Dexamethasone, injected intracerebrally (i.c.v.) 10 minutes before morphine, dose-dependently reduced morphine antinociception, whereas R...

journal_title：Life sciences

authors： Capasso A,Di Giannuario A,Loizzo A,Pieretti S,Sorrentino L

更新日期：1992-01-01 00:00:00

abstract：:The multiple functions of the blood-brain barrier (BBB) consist mostly in membrane properties controlling the bidirectional exchange of molecules between the general circulation and the central nervous system. As lipophilic molecules are able to easily penetrate the membrane of brain microvessels endothelial cells, an...

journal_title：Life sciences

authors： Ghersi-Egea JF,Minn A,Siest G

更新日期：1988-01-01 00:00:00

abstract：:A phencyclidine (PCP) receptor binding site has been solubilized in an active ligand-binding state from rat cerebral cortical membranes with sodium deoxycholate. Optimal receptor solubilization occurs at a detergent/protein ratio of 0.5 (w/w); for 5 mg protein/ml solubilized with 0.25% sodium deoxycholate, about 60% o...

journal_title：Life sciences

authors： McVittie LD,Sibley DR

更新日期：1989-01-01 00:00:00

abstract：:Aberrant methylation of promoter CpG islands (CGIs) can inactivate the expression of many tumor suppressor genes and play an important role in the carcinogenesis of gastric cancer. The tumor suppressor gene RB1, which encodes a cell cycle regulator, is hypermethylated and downregulated in multiple kinds of cancer. Act...

journal_title：Life sciences

authors： Cao D,Jia Z,Wu Y,Su T,Zhao D,Wu M,Tsukamoto T,Oshima M,Jiang J,Cao X

更新日期：2020-12-15 00:00:00

abstract：:Although the aging effect of dopamine D2 receptor in the striatum is well-documented, the effect of age on the extrastriatal dopamine D2 receptor has not been fully examined. Since the density of extrastriatal dopamine D2 receptor is very low, suitable ligands are limited. In this study, we used [11C]FLB 457 to quanti...

journal_title：Life sciences

authors： Inoue M,Suhara T,Sudo Y,Okubo Y,Yasuno F,Kishimoto T,Yoshikawa K,Tanada S

更新日期：2001-07-20 00:00:00

abstract：:We previously reported the discovery and partial characterization of bovine atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor, which is associated with atrial granule membranes. We now report the physicochemical properties of electrophoretically homogeneous enzyme purifie...

journal_title：Life sciences

authors： Wypij DM,Harris RB

更新日期：1992-01-01 00:00:00

abstract：:Unconjugated bilirubin (UCB), like trifluoperazine (TFP), dibucaine (DBC) and praziquantel (PZQ), induces erythrocyte morphological changes, lysis and lipid exfoliation. In the present study we determined whether TFP, DBC and PZQ toxicity to erythrocytes was potentiated or reverted by UCB. Human erythrocytes were eith...

journal_title：Life sciences

authors： Brito MA,Malheiros SV,Meirelles NC,Brites D

更新日期：2001-07-13 00:00:00

abstract：:1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site on the NMDA receptor, prevents tolerance to the mu opioid morphine and the delta ligand [D-Pen2,D-Pen5]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence tolerance to the kappa1 op...

journal_title：Life sciences

authors： Kolesnikov YA,Maccechini ML,Pasternak GW

更新日期：1994-01-01 00:00:00

abstract：:We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li(+)), magnesium (Mg(2+)), and potassium (K(+)) were measured in rat plasma and cerebral cortex using an HPLC meth...

journal_title：Life sciences

authors： Sastre E,Nicolay A,Bruguerolle B,Portugal H

更新日期：2005-07-01 00:00:00

abstract：:The aim of the present study was to investigate the existence of aging- and sex-related alterations in the permeability of the blood-brain barrier (BBB) in the rat, by calculating a unidirectional blood-to-brain transfer constant (Ki) for the circulating tracer [14C]-alpha-aminoisobutyric acid. We observed that: a) th...

journal_title：Life sciences

authors： Saija A,Princi P,D'Amico N,De Pasquale R,Costa G

更新日期：1990-01-01 00:00:00

abstract：:Semicarbazones induce an anticonvulsant effect in different experimental models. As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated. BS (10, 25 or 50 mg/kg, i.p.) markedly inhibited the sec...

journal_title：Life sciences

authors： Rocha LT,Costa KA,Oliveira AC,Nascimento EB Jr,Bertollo CM,Araújo F,Teixeira LR,Andrade SP,Beraldo H,Coelho MM

更新日期：2006-06-27 00:00:00

abstract：:Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was a...

journal_title：Life sciences

authors： Carrillo MC,Kanai S,Nokubo M,Kitani K

更新日期：1991-01-01 00:00:00

abstract：:10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...

journal_title：Life sciences

authors： Szalay KS

更新日期：1993-01-01 00:00:00

abstract：:The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltre...

journal_title：Life sciences

authors： Eikelboom R

更新日期：1987-03-16 00:00:00