Central interaction of dexamethasone and RU-38486 on morphine antinociception in mice.

abstract：:Interleukin (IL)-1 beta is a pro-inflammatory cytokine that has been shown to play a pivotal role in the onset of inflammatory bowel disease (IBD), however, the molecular mechanisms underlying the production of IL-1 beta in IBD are not fully understood. We investigated dextran sulfate sodium (DSS)-induced IL-1 beta pr...

journal_title：Life sciences

authors： Kwon KH,Ohigashi H,Murakami A

更新日期：2007-07-12 00:00:00

abstract：:It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway. We found that contrary to the earlier reports, two of the phytopathogen...

journal_title：Life sciences

authors： Khan AJ,Minocha SC

更新日期：1989-01-01 00:00:00

abstract：:Nociceptin/orphanin FQ (=N/OFQ), the endogenous ligand of ORL1 receptor (=NOP), has been reported to induce, in rodents, after intracerebroventricular (i.c.v.) administration, anti-stress and anxiolytic effects. We have observed that the handling of mice followed by an i.c.v. injection of saline, induced a marked incr...

journal_title：Life sciences

authors： Le Cudennec C,Naudin B,Do Rego JC,Costentin J

更新日期：2002-11-29 00:00:00

abstract：:The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growt...

journal_title：Life sciences

authors： Burch RM,Kyle DJ

更新日期：1992-01-01 00:00:00

abstract：AIMS:Hyperhomocysteinemia (Hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. Epigenetic mechanisms play an important role in the pathogenesis of atherosclerosis induced by Hhcy. However, the exact mechanism is still undefined. Lesional apoptotic cells and necrotic core forma...

journal_title：Life sciences

authors： Cong G,Yan R,Huang H,Wang K,Yan N,Jin P,Zhang N,Hou J,Chen D,Jia S

更新日期：2017-03-15 00:00:00

abstract：:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with ...

journal_title：Life sciences

authors： Fang M,Li J,Rudd JA,Wai SM,Yew JC,Yew DT

更新日期：2006-02-09 00:00:00

abstract：:N-acyl dehydroalanines have been shown to react with and scavenge oxygen derived free radicals. One of those compounds, the AD-5 (N-(paramethoxyphenylacetyl) dehydroalanine) has been examined for its ability to decrease the amount of reactive oxygen species which appeared when liver microsomes (isolated from rats pret...

journal_title：Life sciences

authors： Buc-Calderon P,Roberfroid M

更新日期：1990-01-01 00:00:00

abstract：:In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmente...

journal_title：Life sciences

authors： Yanagida M,Gohda E,Yamamoto I

更新日期：1996-01-01 00:00:00

abstract：:Increased levels of particulate matter (PM) air pollutants in East Asia have resulted in detrimental health impacts increasing morbidity and mortality. Epidemiological studies suggest a possible relation between the cutaneous exposure of PM and increased oxidative stress and inflammation which lead to skin lesions. Th...

journal_title：Life sciences

authors： Fernando IPS,Jayawardena TU,Kim HS,Vaas APJP,De Silva HIC,Nanayakkara CM,Abeytunga DTU,Lee W,Ahn G,Lee DS,Yeo IK,Jeon YJ

更新日期：2019-09-15 00:00:00

abstract：BACKGROUND:Cigarette smoke extract (CSE) affects the expression of non-neuronal components of cholinergic system in bronchial epithelial cells and, as PEBP1/Raf-mediated MAPK1/2 and ERK1/2 pathway, promotes inflammation and oxidative stress. AIMS:We studied whether Acetylcholine (ACh) is involved in the mechanism of c...

journal_title：Life sciences

authors： Albano GD,Bonanno A,Moscato M,Anzalone G,Di Sano C,Riccobono L,Wenzel SE,Profita M

更新日期：2018-01-01 00:00:00

abstract：:Voltage clamp recordings of GH3/B6 pituitary cells reveal the presence of non linear steady state membrane properties at the level of the resting potential (about -41 mV). Clamping the cells to potentials more depolarized than -60 mV is associated with a potential dependent increase in membrane conductance and membran...

journal_title：Life sciences

authors： Dufy B,Barker JL

更新日期：1982-05-31 00:00:00

abstract：:As a decrease in cholinergic neurons has been observed in Alzheimer's Disease (AD), therapeutic approaches to AD include inhibition of acetylcholinesterase to increase acetylcholine levels. Evidence suggests that acetylcholine release in the CNS is modulated by negative feedback via presynaptic M2 receptors, blockade ...

journal_title：Life sciences

authors： Lachowicz JE,Lowe D,Duffy RA,Ruperto V,Taylor LA,Guzik H,Brown J,Berger JG,Tice M,McQuade R,Kozlowski J,Clader J,Strader CD,Murgolo N

更新日期：1999-01-01 00:00:00

abstract：:Triiodothyronine (T3) increases phosphoglycerate mutase (PGAM) specific activity in rat skeletal and cardiac muscles. This increase is concomitant with an increase in the proportion of phosphoglycerate mutase isozymes which contain type-M subunit. Propylthiouracil (PTU), an anti-hormone, not only decreases phosphoglyc...

journal_title：Life sciences

authors： Esteller M,Ureña J,Carreras J,Martelly I,Climent F

更新日期：1994-01-01 00:00:00

abstract：:6-mercaptopurine (6-MP) has been used clinically for 40 years to maintain remission in patients with acute lymphoblastic leukemia (ALL). However, central nervous system (CNS) relapses frequently occur in patients with ALL who continuously receive anticancer drugs, including 6-MP, during remission maintenance therapy. ...

journal_title：Life sciences

authors： Deguchi Y,Yokoyama Y,Sakamoto T,Hayashi H,Naito T,Yamada S,Kimura R

更新日期：2000-01-01 00:00:00

abstract：:According to recent epidemiological reports, almost 40% of American population use complimentary and alternative medicine (CAM) during their lifetime. Patients detected with HIV or cancer often consume herbal products especially St. John's wort (SJW) for antidepressants in combination with prescription medicines. Such...

journal_title：Life sciences

authors： Pal D,Mitra AK

更新日期：2006-03-27 00:00:00

abstract：:Free radicals induced by cerebral ischemia-reperfusion injury can trigger lipid peroxidation, leading to the production of malondialdehyde (MDA) and 4-hydroxy-2(E)-nonenal (4-HNE). Post-ischemia electroacupuncture (EA) therapy was able to reduce extent of lipid peroxidation. However, the effect of pre-ischemic EA ther...

journal_title：Life sciences

authors： Siu FK,Lo SC,Leung MC

更新日期：2004-07-30 00:00:00

abstract：:Extracts of Hypericum perforatum (St. John's wort) have antidepressant properties in depressed patients and exert antidepressant-like action in laboratory animals. The phloroglucinol derivative hyperforin has become a topic of interest, as this Hypericum component is a potent inhibitor of monoamines reuptake. The mole...

journal_title：Life sciences

authors： Roz N,Rehavi M

更新日期：2003-06-13 00:00:00

abstract：:This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on langua...

journal_title：Life sciences

authors： Normando VMF PhD,Dias ÁRN Me,da Silva ALSE Lic,da Silva Pinto D PhD,de Souza Santos MC PhD,Rodrigues CL Lic,de Oliveira EM PhD,de Souza Filho LEC Me,de Brito Vieira W Esp,Andriolo RB PhD,Sousa RCM PhD,Falcão LFM PhD,Quaresma JAS

更新日期：2020-09-01 00:00:00

abstract：AIMS:Active immunization with human vascular endothelial growth factor (hVEGF) vaccines provides a therapeutic option instead of bevacizumab therapy. However, the immunity to self-molecule is difficult to elicit due to immune tolerance. A bioactive peptide of two tandem repeats of mHSP70407-426 (M2) has exhibited poten...

journal_title：Life sciences

authors： Xu M,Zhang Y,Dong W,Jiang L,Zhang J,Yu P,Xie S,Zhou L

更新日期：2018-05-15 00:00:00

abstract：:Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performanc...

journal_title：Life sciences

authors： Zagon IS,Hurst WJ,McLaughlin PJ

更新日期：1998-01-01 00:00:00

abstract：:The effects of methadone and morphine on fetal behavior were studied following their administration to either the mother (5micrograms/kg/min) or fetus (0.5micrograms/kg maternal wt./min) using the chronically-instrumented pregnant ewe model. Fourteen unanesthetized, unrestrained pregnant ewes between 130-141 days gest...

journal_title：Life sciences

authors： Umans JG,Szeto HH

更新日期：1983-01-01 00:00:00

abstract：:The fructose analogue 2,5-anhydro-D-mannitol (2,5-AM), that inhibits glucose release and ATP formation in liver cells, seems to stimulate feeding by acting on the liver, because hepatic portal injection was more effective than jugular vein injection and because hepatic branch vagotomy attenuated 2,5-AM's hyperphagic e...

journal_title：Life sciences

authors： Lutz TA,Boutellier S,Scharrer E

更新日期：1998-01-01 00:00:00

abstract：AIMS:The effects of chronic administration of Ferutinin (phytoestrogen found in the plants of genus Ferula), compared with those elicited by estradiol benzoate, were evaluated, following ovariectomy, on the uterus of ovariectomized rats as regard weight, size, structure and histomorphometry. MAIN METHODS:The experimen...

journal_title：Life sciences

authors： Ferretti M,Bertoni L,Cavani F,Benincasa M,Sena P,Carnevale G,Zavatti M,Viesti VD,Zanoli P,Palumbo C

更新日期：2012-01-16 00:00:00

abstract：:Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressu...

journal_title：Life sciences

authors： Ames JR,Ryan MD,Kovacic P

更新日期：1987-10-19 00:00:00

abstract：:A natural product betulinic acid (BA) has gained a huge significance in the recent years for its strong cytotoxicity. Surprisingly, in spite of being an interesting cancer protecting agent on a variety of tumor cells, the normal cells and tissues are rarely affected by BA. Betulinic acid and analogues (BAs) generally ...

journal_title：Life sciences

authors： Kumar P,Bhadauria AS,Singh AK,Saha S

更新日期：2018-09-15 00:00:00

abstract：AIMS:The p53 protein, also called guardian of the genome, has a key role in cell cycle regulation. It is activated under stressful circumstances, such as DNA damage which results in permanent arrest or cell death. The protein is disabled in several types of human cancer due to over-expression of the two regulators, Mdm...

journal_title：Life sciences

authors： Golestanian S,Sharifi A,Popowicz GM,Azizian H,Foroumadi A,Szwagierczak A,Holak TA,Amanlou M

更新日期：2016-01-15 00:00:00

abstract：AIMS:This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. MATERIALS AND METHODS:hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no ex...

journal_title：Life sciences

authors： Cho SE,Kim YM,Jeong JS,Seo YK

更新日期：2016-11-15 00:00:00

abstract：AIM:The aim of the present study was to assess and compare the effect of 17β-estradiol and two different selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, as well as a selective estrogen receptor alpha agonist, propyl-pyrazole-triol (PPT) and a selective estrogen receptor beta agonist, diarylpro...

journal_title：Life sciences

authors： Baraka AM,Korish AA,Soliman GA,Kamal H

更新日期：2011-05-09 00:00:00

abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...

journal_title：Life sciences

authors： Zhao Y,Shen F,Gong M,Jin L,Ren X,Liu K,Lu J

更新日期：2020-06-15 00:00:00

abstract：:Stonustoxin (SNTX) is a 148 kDa, dimeric, hypotensive and lethal protein factor isolated from the venom of the stonefish Synanceja horrida. SNTX (10-320 ng/ml) progressively causes relaxation of endothelium-intact, phenylephrine (PE)-precontracted rat thoracic aortic rings. The SNTX-induced vasorelaxation was inhibite...

journal_title：Life sciences

authors： Liew HC,Khoo HE,Moore PK,Bhatia M,Lu J,Moochhala SM

更新日期：2007-04-10 00:00:00