Abstract：
:The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growth, and leukocyte activation have become topics of study. Kininogen precursors, synthetic kallikreins, and degradative kininases have been characterized in detail with regard to catalytic mechanisms, physical structure and gene regulation; however, the actual receptors for bradykinin are still only poorly understood. This situation is caused by the lack of availability of potent, specific receptor antagonists. However, specific bradykinin receptor antagonists became available in 1985, and several very potent classes of agents are now available; also, the first bradykinin receptor has been cloned.
journal_name
Life Scijournal_title
Life sciencesauthors
Burch RM,Kyle DJdoi
10.1016/0024-3205(92)90201-ysubject
Has Abstractpub_date
1992-01-01 00:00:00pages
829-38issue
12eissn
0024-3205issn
1879-0631pii
0024-3205(92)90201-Yjournal_volume
50pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：:Thirty-four novel, diaryl ω-(isothiocyanato)alkylphosphonates with chlorine atom and methoxy, dimethoxy, methylsulfanyl, or methoxycarbonyl groups at ortho, meta, or para positions of the phenyl ring, and with an unbranched alkyl chain (n = 2-6) were designed and synthesized in a one-pot reaction in 11-76% yields. All...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.01.020
更新日期：2019-02-15 00:00:00
abstract：AIMS:The purpose of this study was to determine a relatively short-term effect of feeding an α-linolenic acid (ALA, n-3)-restricted, linoleic acid (LA, n-6)-adequate diet on neurotrophin contents and protein kinase activities in brain regions of the mouse. MAIN METHODS:After feeding mice a safflower oil (SAF) diet (AL...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.09.003
更新日期：2010-10-09 00:00:00
abstract：:We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related pept...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90618-8
更新日期：1989-01-01 00:00:00
abstract：:The aim of the present study was to assess the effects of peanut (Arachis hypogaea L.) shell extracts (PSE) on lipases and to evaluate its potential development for the treatment of obesity. The peanut shells were extracted in 95% ethanol, and the extracts were screened for inhibitory effects on pancreatic lipase (PL)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.11.012
更新日期：2006-05-08 00:00:00
abstract：:This study, conducted on isolated guinea pig ileum, was designed to establish the mechanism of presynaptic alpha 2-adrenoreceptor blockade by the tetramine disulfides, benextramine and pyrextramine. At 1 microM these drugs irreversibly blocked norepinephrine (NE)-induced inhibition of the twitch response to electrical...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90407-8
更新日期：1986-05-05 00:00:00
abstract：:The purpose of this investigation was to determine the effects of experimental dicrocoeliosis on bile formation in the hamster. Studies were carried out at 120 days after infection with an oral dose of 40 metacercariae of Dicrocoelium dendriticum. A significant elevation in bile flow (+20%) and in the biliary output o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00474-3
更新日期：1998-01-01 00:00:00
abstract：:Effects of scratching behavior on dermatitis, transepidermal water loss (TEWL) and serum IgE concentrations were examined in NC/Nga (NC) mice with toenails (WIT) and without toenails (WOT). The first study was a preventive treatment done to cut off hind toenails before dermatitis induction and the second study was a t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.07.022
更新日期：2004-12-31 00:00:00
abstract：:Hydrolysis of fragments of the C-terminal and mid-portions of parathyroid hormone (PTH) by a phosphoramidon-insensitive metallo-endopeptidase, previously purified by us from the microvillar membranes of rat kidney, and by the microvillar membranes of rat kidney themselves were investigated using a reverse-phase HPLC, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00795-0
更新日期：1994-01-01 00:00:00
abstract：:Retinoic acids and their cognate nuclear receptors exert a substantial regulatory role in cell growth and development as well as in the neuroendocrine system. These effects are primarily mediated by all-trans retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor superfamily of ligand inducibl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00496-3
更新日期：2000-03-24 00:00:00
abstract：AIMS:Wistar-Kyoto rats (HA-WKY) kept in the author's laboratory showed higher levels of serum adiponectin (approximately 4-fold) compared with Wistar-Kyoto/Izm rats (WKY/Izm), a WKY standard strain, at 6weeks old. In a preliminary study, HA-WKY but not WKY/Izm showed hyperinsulinemia and severe hypercholesterolemia whe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.01.003
更新日期：2010-02-27 00:00:00
abstract：:A number of studies have been made on the role played by endogenous opioid peptides in the secretion of LH in humans. However no previous studies have compared the effects of the most potent pharmacological agonist and antagonist, morphine and naloxone, in the same subjects. The present study examined the acute effect...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90209-2
更新日期：1986-06-09 00:00:00
abstract：:Hexokinase and glucose-6-phosphate dehydrogenase activities were studied in brain regions after intraventricular injection of kainic acid. Hexokinase activity was decreased by 10-15% in various regions while glucose-6-phosphate dehydrogenase activity remained unaltered. Soluble hexokinase activity, which remained the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90471-m
更新日期：1991-01-01 00:00:00
abstract：:Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and suli...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.028
更新日期：2006-11-10 00:00:00
abstract：AIMS:Opioid addiction is associated with long-term adaptive changes in the brain that involve protein expression. The carboxyl-terminal of the μ opioid receptor (MOR-C) is important for receptor signal transduction under opioid treatment. However, the proteins that interact with MOR-C after chronic morphine exposure re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.10.032
更新日期：2015-12-15 00:00:00
abstract：AIMS:Fenofibrate is a peroxisome proliferator-associated receptor alpha agonist (PPARα) used clinically for the management of dyslipidemia and is a myocardial fatty acid oxidation stimulator. It has also been shown to have cardiac anti-hypertrophic properties but the effects of fenofibrate on the development of eccentr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.10.022
更新日期：2013-01-17 00:00:00
abstract：AIMS:Paraquat (PQ) is known to induce pulmonary injury via a redox cyclic reaction. The present study was aimed to determine the protective effects of quercetin against PQ-induced pulmonary injury in association with its antioxidant activity. MAIN METHODS:Male rats were challenged acutely by PQ (50 mg/kg, i.p.) with o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.06.011
更新日期：2010-07-31 00:00:00
abstract：:The level of hepatic lipidperoxides in chick embryos was determined during cataract formation resulting from glucocorticoid treatment. When 15 day old chick embryos were administered 0.25 mumol of hydrocortisone acetate their hepatic lipidperoxide level, determined by thio-barbituric acid, increased after a lag time o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90664-7
更新日期：1984-08-27 00:00:00
abstract：:Experiments were undertaken to examine the characteristics of the adrenergic receptor-coupled cAMP system in rat brain slices. It was found that the potentiation of isoproterenol-stimulated cAMP accumulation by 6-fluoronorepinephrine, an alpha-adrenergic agonist, is largely dependent upon the degree of beta-receptor o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90129-8
更新日期：1985-09-30 00:00:00
abstract：:Intravenous (640 micrograms/kg) or intracerebroventricular (0.5 and 1 microgram) injection of Escherichia coli endotoxin (LPS) causes inhibition of water intake induced by 24 hour period of water deprivation in the rat. Tumor necrosis factor alpha (TNF-alpha; 20 and 40 ng/rat) given into the lateral cerebral ventricle...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90154-h
更新日期：1992-01-01 00:00:00
abstract：:To determine the mechanism of anoxic vasoconstriction, precontracted rat aortic rings were exposed to 95% N2, which caused additional contraction. Reoxygenation (95% O2) resulted in initial relaxation followed by contraction. Indomethacin did not affect anoxic contraction or reoxygenation-mediated events, but NG-monom...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90316-4
更新日期：1991-01-01 00:00:00
abstract：AIM:Muscle atrophy is a common symptom after nerve denervation. Myostatin propeptide, a precursor of myostatin, has been documented to improve muscle growth. However, the mechanism underlying the muscle atrophy attenuation effects of myostatin propeptide in muscles and the changes in gene expression are not well establ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.12.056
更新日期：2016-02-01 00:00:00
abstract：AIMS:Inducible nitric oxide synthase (iNOS) pathway has been in the limelight since its discovery as a key mediator in the process of liver fibrogenesis. Therefore, the objective of the current study was to elucidate the in vivo molecular mechanism underlying the hepatic preventive relevance of eugenol (EUG) and telmis...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.11.031
更新日期：2019-01-01 00:00:00
abstract：AIMS:Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF. MATERIALS AND METHODS:We analyzed mRNA of human non-failing...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.01.021
更新日期：2018-03-01 00:00:00
abstract：:Our previous research with long term cannabis users established an impaired ability to focus attention and filter out irrelevant information, which was progressive with the cumulative duration of exposure to cannabis. The current study examined these processes in a group of ex-cannabis users. The results suggested a p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00197-e
更新日期：1995-01-01 00:00:00
abstract：:We provide direct evidence that verapamil inhibits active digoxin secretion in renal tubular cells (LLC-PK1), and that verapamil increases cellular accumulation of digoxin. These findings suggest that verapamil inhibits the digoxin active secretory transport at the apical membranes, supporting the theory that P-glycop...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90667-r
更新日期：1993-01-01 00:00:00
abstract：:The effects of aging on contractile response to angiotensin II and tachyphylaxis to it were investigated using aortic strips from rats aged 1.5, 4 and 22 months. Whether the endothelium was present or not, the contractile response to angiotensin II was greater and tachyphylaxis to it was less in 1.5-month-old rats tha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90549-7
更新日期：1990-01-01 00:00:00
abstract：:The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely us...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118493
更新日期：2020-12-01 00:00:00
abstract：AIMS:Although dexamethasone (Dex) is used widely as an anti-inflammatory and immunosuppressive drug, Dex appears to have severe side-effects, including osteoporosis. This study determined the effects of Dex on duodenal and renal expressions of the calcium-processing genes transient receptor potential cation channel, su...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.05.013
更新日期：2009-07-17 00:00:00
abstract：AIMS:The objectives of this study were to determine the cytokine induction by delta tocotrienol (DT3, a promising radiation countermeasure) and to investigate the role of granulocyte colony-stimulating factor (G-CSF) in its radioprotective efficacy against ionizing radiation in mice. MAIN METHODS:Multiplex Luminex was...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.01.065
更新日期：2014-03-11 00:00:00
abstract：AIMS:Cold stress has been shown to produce dramatic increases in 2-fluoro-2-deoxy-D-Glucose ((18)FDG) accumulation by brown adipose tissue (BAT) in rodents. However, neither the effects of other types of stress on (18)FDG accumulation nor the effects of stressors on the accumulation of tracers of other aspects of energ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.04.014
更新日期：2011-07-18 00:00:00
