Cloricromene antagonizes antidipsogenic effects induced by endotoxin, but not by TNF alpha, in the rat.

abstract：:Intracellular calcium plays an important role on the pathogenesis of hypoxia-induced cellular injury. Calbindin-D(28k), a cytosolic vitamin D-dependent calcium binding protein, can serve as a buffer to limit a surge in intracellular Ca2+ concentration ([Ca2+]i) induced by various stimulations. To evaluate the possible...

journal_title：Life sciences

authors： Wu MJ,Lai LW,Lien YH

更新日期：2002-06-21 00:00:00

abstract：:Diesel particles form a large component of the fine particle fraction (PM10) in urban air in the UK. During pollution episodes small increases in PM10 have been linked to detrimental health effects. The comparative toxicological effects of diesel exhaust and other well-characterised particles (carbon black, amorphous ...

journal_title：Life sciences

authors： Murphy SA,BéruBé KA,Pooley FD,Richards RJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Quercetin is a major flavonoid in various plants. It possesses the multiple pharmacological actions like vascular integrity and regulatory action of the blood-brain barrier. AIMS:The present study is focused on evaluating the role of solid lipid nanoparticle of quercetin in pentylenetetrazole (PTZ) induced ...

journal_title：Life sciences

authors： Rishitha N,Muthuraman A

更新日期：2018-04-15 00:00:00

abstract：:The aim of this study was to examine the morphological and functional changes in rabbit mesenteric arterial tissue cultured with fetal bovine serum. In the endothelium-denuded arteries cultured under a serum-free condition for one week (serum-free arteries), morphology of the smooth muscle layer was intact. In the ser...

journal_title：Life sciences

authors： Yamawaki H,Sato K,Hori M,Ozaki H,Nakamura S,Nakayama H,Doi K,Karaki H

更新日期：2000-07-07 00:00:00

abstract：:In order to determine whether CCl4, CBrCl3, CBr4 or CHCl3 undergo oxidative metabolism to electrophilic halogens by liver microsomes, they were incubated with liver microsomes from phenobarbital pretreated rats in the presence of NADPH and 2,6-dimethylphenol. The analysis of the reaction mixtures by capillary gas chro...

journal_title：Life sciences

authors： Mico BA,Branchflower RV,Pohl LR,Pudzianowski AT,Loew GH

更新日期：1982-01-11 00:00:00

abstract：:Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, which lead to multiple organ dysfunction. The aim of this study was to examine the role of melatonin, a potent antioxidant, in protecting the intestinal and bladder tissues against damage in a rat model of sepsis. Sepsis was induced...

journal_title：Life sciences

authors： Paskaloğlu K,Sener G,Kapucu C,Ayanoğlu-Dülger G

更新日期：2004-01-16 00:00:00

abstract：:Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...

journal_title：Life sciences

authors： Riddle MA,Shaywitz BA,Leckman JF,Anderson GM,Shaywitz SE,Hardin MT,Ort SI,Cohen DJ

更新日期：1986-03-17 00:00:00

abstract：:Interleukin-18 (IL-18) is a novel proinflammatory cytokine that was recently found in synovial fluids and synovial tissues from patients with rheumatoid arthritis (RA). To investigate the role of IL-18 in rheumatoid synovitis, the levels of IL-18 and serum amyloid A (SAA) were measured in synovial fluids from 24 patie...

journal_title：Life sciences

authors： Tanaka F,Migita K,Kawabe Y,Aoyagi T,Ida H,Kawakami A,Eguchi K

更新日期：2004-02-13 00:00:00

abstract：:The purpose of this study was to explore the feasibility of utilizing the granatanol: N-methyl [9-azabicyclo (3.3.1) nonane] 3-alpha-ol as the terminal group in a series of new bisquaternary azabicycyclic diester-type neuromuscular blocking agents. Fifty two bisquaternary ammonium derivatives of several dicarboxylic a...

journal_title：Life sciences

authors： Gyermek L,Lee C,Cho YM,Nguyen N

更新日期：2006-07-04 00:00:00

abstract：:Morphine sulfate and other opiate/narcotic analgesics are the most effective treatments for acute and chronic severe pain. However, their clinical utility is often hampered by the development of analgesic tolerance. This complex pathophysiological cycle contributes significantly to decreased quality of life in the gro...

journal_title：Life sciences

authors： Salvemini D,Neumann W

更新日期：2010-04-10 00:00:00

abstract：:Tramadol is a clinically-effective, centrally-acting analgesic. This drug is a racemic mixture of two enantiomers, each one displaying different mechanisms: (+)tramadol displays opioid agonist properties and inhibits serotonin reuptake while (-)tramadol inhibit preferentially noradrenaline reuptake. The action of tram...

journal_title：Life sciences

authors： Rojas-Corrales MO,Gibert-Rahola J,Micó JA

更新日期：1998-01-01 00:00:00

abstract：:Maternal malnutrition is known to impair fetal growth and predispose to the development of hypertension and type 2 diabetes. Recently, studies have demonstrated that intrauterine malnutrition is followed later in male offspring by oxidative stress characterized by increased superoxide generation due to activation of N...

journal_title：Life sciences

authors： Franco MC,Akamine EH,Rebouças N,Carvalho MH,Tostes RC,Nigro D,Fortes ZB

更新日期：2007-01-30 00:00:00

abstract：:Intestinal mucosa, bone marrow hematopoietic cells and brain have limited capacity for the de novo synthesis of nucleosides (NSs) and nucleotides (NTs). Whereas the role of dietary NS and NT in the former two tissues is known, it is not known in the brain. Therefore we studied the effect of dietary NS and NT mixture o...

journal_title：Life sciences

authors： Chen TH,Huang HP,Matsumoto Y,Wu SH,Wang MF,Chung SY,Uezu K,Moriyama T,Uezu E,Korin T,Sato S,Yamamoto S

更新日期：1996-01-01 00:00:00

abstract：AIMS:Oxidative stress and inflammatory response are major factors causing several tissue injuries in intestinal ischemia and reperfusion (I/R). Agmatine has been reported to attenuate I/R injury of various organs. The present study aims to analyze the possible protective effects of agmatine on intestinal I/R injury in ...

journal_title：Life sciences

authors： Turan I,Ozacmak HS,Ozacmak VH,Barut F,Araslı M

更新日期：2017-11-15 00:00:00

abstract：:The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes throughout development and adult life. Growing evidences have suggested that deregulation of the Wnt canonical pathway could be involved in the pathogenesis of neurodegenerative diseases. The Wnt canonical signaling is a pathway tightly ...

journal_title：Life sciences

authors： Libro R,Bramanti P,Mazzon E

更新日期：2016-08-01 00:00:00

abstract：AIMS:Several lines of evidence support the hypothesis that the oxidation of low density lipoprotein (LDL) may play a crucial role in the initiation and progression of atherosclerosis. Various studies have shown a positive effect of antioxidant compounds on oxidative modification of LDL and atherogenesis. In view of thi...

journal_title：Life sciences

authors： de Lima Portella R,Barcelos RP,de Bem AF,Carratu VS,Bresolin L,da Rocha JB,Soares FA

更新日期：2008-12-19 00:00:00

abstract：:Previous research has shown that the CAMK (calcium/calmodulin dependent protein kinase) inhibitor, KN62, can lead to reductions in insulin stimulated glucose transport. Although controversial, an L-type calcium channel mechanism has also been hypothesized to be involved in insulin stimulated glucose transport. The pur...

journal_title：Life sciences

authors： Wright DC,Fick CA,Olesen JB,Lim K,Barnes BR,Craig BW

更新日期：2004-01-02 00:00:00

abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...

journal_title：Life sciences

authors： Naderi N,Hemmatinafar M,Gaeini AA,Bahramian A,Ghardashi-Afousi A,Kordi MR,Darbandi-Azar A,Karimzade F,Mohebbi H,Barati M

更新日期：2019-03-15 00:00:00

abstract：AIMS:Dorsal root ganglia contain heterogeneous populations of primary afferent neurons that transmit various sensory stimuli. This functional diversity may be correlated with differential expression of voltage-gated K(+) (Kv) channels. Here, we examine cellular distributions of Kv4 pore-forming and ancillary subunits t...

journal_title：Life sciences

authors： Matsuyoshi H,Takimoto K,Yunoki T,Erickson VL,Tyagi P,Hirao Y,Wanaka A,Yoshimura N

更新日期：2012-09-17 00:00:00

abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by symptoms that include social communication impairments, interaction deficits, and repetitive and stereotyped behaviors. Recent studies have suggested that imbalanced cytokine levels are associated with impaired behavioral outcomes in ind...

journal_title：Life sciences

authors： Ahmad SF,Nadeem A,Ansari MA,Bakheet SA,Alasmari F,Alasmari AF,Al-Kharashi LA,Al-Qahtani QH,Attia SM

更新日期：2019-11-15 00:00:00

abstract：:A novel beta-carboline with benzodiazepine-like properties has recently been synthesized. We compared the effect of the i.v. administration of this drug, ZK 93423, with diazepam on the activity of nigral pars reticulata neurons which are known to be very sensitive to the inhibitory effect produced by GABA-mimetics and...

journal_title：Life sciences

authors： Mereu G,Corda MG,Carcangiu P,Giorgi O,Biggio G

更新日期：1987-04-06 00:00:00

abstract：AIMS:Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress. In order to find an effective strategy to prevent fatigue or enhance recovery, the effects of a combination of mitochondrial targeting nutrients on physical activity, mitochondrial function and oxidative stress in exercised ra...

journal_title：Life sciences

authors： Sun L,Shen W,Liu Z,Guan S,Liu J,Ding S

更新日期：2010-01-02 00:00:00

abstract：OBJECTIVE:To estimate the alterations of paraoxonase 1 (PON1) and high-density lipoprotein (HDL) in rheumatoid arthritis (RA). DESIGN AND METHODS:We investigated the serum enzyme activity and concentration of PON1 and their relationship with serum lipids, high-density lipoprotein (HDL) parameters, and acute phase reac...

journal_title：Life sciences

authors： Tanimoto N,Kumon Y,Suehiro T,Ohkubo S,Ikeda Y,Nishiya K,Hashimoto K

更新日期：2003-05-09 00:00:00

abstract：:Adult female Sprague-Dawley rats were prepared with permanent cortical EEG and temporalis EMG electrodes and i.v. cannulae. They were made tolerant to and physically dependent on morphine by automatic, hourly injections. These physically dependent rats were then trained to lever press for 10 mg/kg injections of morphi...

journal_title：Life sciences

authors： Khazan N,Young GA,Calligaro D

更新日期：1983-01-01 00:00:00

abstract：:Angiotensin (AII) and atrial natriuretic peptide (ANP) exert opposite effects on phosphorylation of a 17.6 kDa nuclear protein from bovine adrenal glomerulosa cells. The protein was separated by sodium dodecyl sulfate electrophoresis and blotted onto polyvinylidene difluoride, and the N-terminal sequence was obtained....

journal_title：Life sciences

authors： Elliott ME

更新日期：1990-01-01 00:00:00

abstract：:Cerebroventricular perfusate (CVP) from rats subjected to endotoxic shock was infused into the lateral ventricle of the naive rat. This procedure produced a hypotensive response in the recipient rat which could be reversed by the intravenous injection of the opioid antagonist naltrexone. The degree of endotoxemic hypo...

journal_title：Life sciences

authors： Xu T,Wang T,Han JS

更新日期：1992-01-01 00:00:00

abstract：:Trifluoperazine (5-200 microM) stimulated the release of 3H-NE from isolated whole pineal glands in a dose dependent manner. Trifluoperazine-induced release was not dependent on extracellular Ca++, whereas 60 mM K+-evoked release was attenuated in the presence of EGTA and zero Ca++ Krebs. 60 mM K+ and 50 microM triflu...

journal_title：Life sciences

authors： Yurko KA,Quenzer LF

更新日期：1986-04-14 00:00:00

abstract：:Brief electrical pulses applied to the rat tail elicit a complex vocal response which includes audible (peeps, chatters) and ultrasonic (USV) components. Aspirin and amitriptyline had no effect on the vocal responses. Morphine showed a dose-dependent and naloxone reversible antinociceptive effect on the 1st and 2nd au...

journal_title：Life sciences

authors： Jourdan D,Ardid D,Chapuy E,Le Bars D,Eschalier A

更新日期：1998-01-01 00:00:00

abstract：:Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all t...

journal_title：Life sciences

authors： Glennon RA,Young R,Benington F,Morin RD

更新日期：1982-02-01 00:00:00

abstract：:Biological properties of homogeneous solutions of chicken (c) and mammalian (m) LHRH were compared by their ability to release LH, in vitro, from a rooster pituitary cell incubation system. Homogeneity of the two LHRH species was confirmed by High Performance Liquid Chromatography (HPLC) using linear gradients of acet...

journal_title：Life sciences

authors： Johnson AL,Dickerman RW,Advis JP

更新日期：1984-05-07 00:00:00