Abstract:
:Trifluoperazine (5-200 microM) stimulated the release of 3H-NE from isolated whole pineal glands in a dose dependent manner. Trifluoperazine-induced release was not dependent on extracellular Ca++, whereas 60 mM K+-evoked release was attenuated in the presence of EGTA and zero Ca++ Krebs. 60 mM K+ and 50 microM trifluoperazine produced an additive effect on 3H-NE release. Clonidine (5 microM) significantly reduced trifluoperazine-induced release by approximately 50% in the presence of Ca++, and in its absence, clonidine significantly attenuated the trifluoperazine response by 42%. Thus trifluoperazine may be acting upon the alpha 2 receptor or intracellular stores of Ca++. These intracellular interactions remain for further study.
journal_name
Life Scijournal_title
Life sciencesauthors
Yurko KA,Quenzer LFdoi
10.1016/0024-3205(86)90472-8subject
Has Abstractpub_date
1986-04-14 00:00:00pages
1393-7issue
15eissn
0024-3205issn
1879-0631pii
0024-3205(86)90472-8journal_volume
38pub_type
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