Abstract：
:The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system. Human neutrophilic polymorphonuclear leukocytes (PMN) were perfused at a shear stress of 1 dyne/cm2 on human umbilical vein endothelial cells (HUVEC) pretreated with IL-1beta (20 U/mL) for 4 hours. Many PMN adhered to IL-1-stimulated HUVEC and then migrated beneath endothelial cell monolayers. Treatment of HUVEC with m-PSL inhibited adherence and migration of PMN in a dose dependent manner. M-PSL also inhibited IL-1beta-induced upregulation of E-selectin and ICAM-1 on HUVEC in a dose dependent manner. These results suggest that m-PSL works as an anti-inflammatory agent through inhibiting PMN-endothelial cell interactions.
journal_name
Life Scijournal_title
Life sciencesauthors
Yoshida N,Yoshikawa T,Nakamura Y,Takenaka S,Sakamoto K,Manabe H,Nakagawa S,Kondo Mdoi
10.1016/s0024-3205(97)00290-7subject
Has Abstractpub_date
1997-01-01 00:00:00pages
2341-7issue
25eissn
0024-3205issn
1879-0631pii
S0024320597002907journal_volume
60pub_type
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