Abstract：
:Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, was administered orally for 12 weeks to male rats with prednisolone-induced osteoporosis. Microdensitometric analysis of a roentgenograph of the femurs revealed that ipriflavone increased the density of the distal metaphysis dose-dependently and tended to increase the density of the diaphysis. It also inhibited dose-dependently the decrease in the mechanical strength of the tibia, breaking strain and breaking energy, and the fractional content of ash in femurs. These results indicate that ipriflavone markedly suppresses bone resorption at the metaphysis where the content of trabecular bone with a rapid turnover rate is high, and possibly inhibits bone reduction at the diaphysis.
journal_name
Life Scijournal_title
Life sciencesauthors
Yamazaki I,Shino A,Shimizu Y,Tsukuda R,Shirakawa Y,Kinoshita Mdoi
10.1016/0024-3205(86)90265-1subject
Has Abstractpub_date
1986-03-10 00:00:00pages
951-8issue
10eissn
0024-3205issn
1879-0631pii
0024-3205(86)90265-1journal_volume
38pub_type
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