5-hydroxytryptamine decreases somatostatin receptors and somatostatin-responsive adenylyl cyclase in rat pancreatic acinar membranes.

abstract：:Chronopharmacokinetics deals with the study of the temporal changes in absorption, distribution, metabolism and elimination and thus takes into account the influence of time of administration on these different steps. In the last decade, numerous studies have been devoted to chronokinetics: recent advances will be rev...

journal_title：Life sciences

authors： Bruguerolle B,Lemmer B

更新日期：1993-01-01 00:00:00

abstract：:Using Sokoloff's 2-deoxyglucose (2-DG) autoradiographic technique, the psychotomimetic drug, phencyclidine (PCP, "angel dust") dramatically increased metabolism in diencephalic and telencephalic brain regions known to be rich in high affinity PCP receptors. These effects were greatest in the limbic circuit described i...

journal_title：Life sciences

authors： Piercey MF,Ray CA

更新日期：1988-01-01 00:00:00

abstract：:The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of flavonols and their glycosides (FOHs), i.e., myricetin (MY), quercetin (Q), morin (MO), kaempferol (K), rutin (R), quercetin galactopyranosi...

journal_title：Life sciences

authors： Dai F,Miao Q,Zhou B,Yang L,Liu ZL

更新日期：2006-04-18 00:00:00

abstract：:U-54494A, a 1,2-diamine anticonvulsant, and U-50488H, a structurally related agonist for opiate kappa receptors, were tested for effects on spontaneous and glutamate-evoked firing rates in cerebral cortex of urethane-anesthetized male Sprague-Dawley rats. Iontophoretic application of 1,2-diamines, glutamate diethyl et...

journal_title：Life sciences

authors： Ochoa MC,Vogelsang GD,Lum JT,VonVoigtlander PF,Piercey MF

更新日期：1992-01-01 00:00:00

abstract：AIMS:Liver fibrosis is a difficult problem in the medical field. We previously reported that curcumol, a bioactive substance, may inhibit the pathological angiogenesis of liver sinusoidal endothelial cells (LSECs) and play a good anti-hepatic fibrosis effect. However, the mechanism of curcumol inhibiting angiogenesis i...

journal_title：Life sciences

authors： Gao L,Yang X,Li Y,Wang Z,Wang S,Tan S,Chen A,Cao P,Shao J,Zhang Z,Zhang F,Zheng S

更新日期：2021-01-01 00:00:00

abstract：AIMS:Extensive evidence supports a role for voltage-gated calcium channels (VGCC) and TRPV1 receptors in pain transmission and modulation. We investigated the profile of analgesic interaction between Phα1β toxin (a VGCC blocker) and SB366791 (selective TRPV1 antagonist) in a model of acute pain induced by capsaicin. Ch...

journal_title：Life sciences

authors： Palhares MR,Silva JF,Rezende MJS,Santos DC,Silva-Junior CA,Borges MH,Ferreira J,Gomez MV,Castro-Junior CJ

更新日期：2017-08-01 00:00:00

abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...

journal_title：Life sciences

authors： Matsui M,Yamada S,Oki T,Manabe T,Taketo MM,Ehlert FJ

更新日期：2004-11-05 00:00:00

abstract：AIMS:Lung cancer represents as the most prevalent tumor globally, among which non-small cell lung cancer (NSCLC) takes up for more than 80%. Lysine demethylase 4A (KDM4A) was dysregulated in NSCLC, but its role on the tumorigenesis in NSCLC cells and the mechanisms of actions are unclear. In this work, we evaluated its...

journal_title：Life sciences

authors： Sun S,Yang F,Zhu Y,Zhang S

更新日期：2020-12-01 00:00:00

abstract：AIMS:Oxidative stress emerges after reperfusion of an organ following an ischemic period and results in tissue damage. In the heart, an amplified generation of reactive oxygen species and a significant Ca(2+) accumulation cause ventricular arrhythmias and mitochondrial dysfunction. This occurs in consequence of increas...

journal_title：Life sciences

authors： Hernández-Esquivel L,Pavón N,Buelna-Chontal M,González-Pacheco H,Belmont J,Chávez E

更新日期：2014-02-06 00:00:00

abstract：:As a decrease in cholinergic neurons has been observed in Alzheimer's Disease (AD), therapeutic approaches to AD include inhibition of acetylcholinesterase to increase acetylcholine levels. Evidence suggests that acetylcholine release in the CNS is modulated by negative feedback via presynaptic M2 receptors, blockade ...

journal_title：Life sciences

authors： Lachowicz JE,Lowe D,Duffy RA,Ruperto V,Taylor LA,Guzik H,Brown J,Berger JG,Tice M,McQuade R,Kozlowski J,Clader J,Strader CD,Murgolo N

更新日期：1999-01-01 00:00:00

abstract：:The neuropeptide substance P (SP) is a mediator of neurogenic inflammation. Also, beta-amyloid protein (beta AP) can directly activate the cell types involved in inflammatory processes. The relationship between SP and beta AP on their biological actions has attracted much interest. SP is trophic in neuronal cells and ...

journal_title：Life sciences

authors： Takenouchi T,Munekata E

更新日期：1995-01-01 00:00:00

abstract：:Involvement of T-type voltage dependent Ca2+ channels (VDCCs) on morphine antinociception, in the development of tolerance and dependence to morphine, and naloxone-precipitated abstinence syndrome in morphine dependent mice was examined by using mibefradil, a T-type VDCCs blocker. Mice were rendered tolerant and depen...

journal_title：Life sciences

authors： Dogrul A,Zagli U,Tulunay FC

更新日期：2002-06-28 00:00:00

abstract：AIMS:Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXRα) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the regulation of lipid metabolism and role of LX...

journal_title：Life sciences

authors： Jin P,Bian Y,Wang K,Cong G,Yan R,Sha Y,Ma X,Zhou J,Yuan Z,Jia S

更新日期：2018-12-01 00:00:00

abstract：:Recent studies suggest that the time of day at which food is consumed dramatically influences clinically-relevant cardiometabolic parameters (e.g., adiposity, insulin sensitivity, and cardiac function). Meal feeding benefits may be the result of daily periods of feeding and/or fasting, highlighting the need for improv...

journal_title：Life sciences

authors： Brewer RA,Collins HE,Berry RD,Brahma MK,Tirado BA,Peliciari-Garcia RA,Stanley HL,Wende AR,Taegtmeyer H,Rajasekaran NS,Darley-Usmar V,Zhang J,Frank SJ,Chatham JC,Young ME

更新日期：2018-03-15 00:00:00

abstract：AIMS:Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity,...

journal_title：Life sciences

authors： El Golli N,Dkhili H,Dallagi Y,Rahali D,Lasram M,Bini-Dhouib I,Lebret M,Rosa JP,El Fazaa S,Allal-El Asmi M

更新日期：2016-02-01 00:00:00

abstract：AIM:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, and thus, the ability of antidiabetic drugs to ameliorate renal microvascular disease may be as important as their ability to control blood glucose. Therefore, we investigated the reno-protective effect of the antidiabetic drugs, Sitagliptin a...

journal_title：Life sciences

authors： Ali SM,Khalifa H,Mostafa DK,El Sharkawy A

更新日期：2016-05-15 00:00:00

abstract：AIMS:To determine whether ginsenoside Rg1 is involved in scratch wound healing through altered expression of related molecules in astrocytes and improved functional recovery after spinal cord injury (SCI). MATERIALS AND METHODS:Astrocytes were isolated from rats, followed by Rg1 treatment. The wound healing test was p...

journal_title：Life sciences

authors： Xu L,Tang YY,Ben XL,Cheng MH,Guo WX,Liu Y,Lu ZF,Deng JL

更新日期：2020-07-01 00:00:00

abstract：:Ro41-0960 is a potent, fluorine containing COMT inhibitor which has be en reported to cross the blood brain barrier and to inhibit COMT in the brain. It is structurally similar to Ro40-7592 which is currently undergoing clinical trials in Parkinson's disease. Positron emission tomographic (PET) studies in baboon using...

journal_title：Life sciences

authors： Ding YS,Gatley SJ,Fowler JS,Chen R,Volkow ND,Logan J,Shea CE,Sugano Y,Koomen J

更新日期：1996-01-01 00:00:00

abstract：:We hypothesized that the atheroinhibitory and cardioprotective effects of estrogen may be mediated in part through increased prostacyclin formation by the artery wall. Atherosclerotic abdominal aorta was collected at necropsy from ovariectomized female monkeys fed an atherogenic diet alone or with added Premarin. Basa...

journal_title：Life sciences

authors： O'Sullivan MG,Goodrich JA,Adams MR

更新日期：2001-06-15 00:00:00

abstract：:Cordyceps sinensis (C. sinensis) is one of the well known fungi used in traditional Chinese medicine for treatment asthma and bronchial and lung inflammation. In this study, effects of C. sinensis methanolic extracts on bronchoalveolar lavage fluids (BALF) cells proliferation, inflammatory cytokines production, and ge...

journal_title：Life sciences

authors： Kuo YC,Tsai WJ,Wang JY,Chang SC,Lin CY,Shiao MS

更新日期：2001-01-19 00:00:00

abstract：AIM:Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildaglip...

journal_title：Life sciences

authors： Nath M,Bhattacharjee K,Choudhury Y

更新日期：2021-02-01 00:00:00

abstract：:Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level depe...

journal_title：Life sciences

authors： Lee JH,Telang FW,Springer CS Jr,Volkow ND

更新日期：2003-08-29 00:00:00

abstract：AIMS:To investigate how Placental Mesenchymal Stem Cells (P-MSCs) would adapt themselves and survive under hypoxic conditions which are prevalent in most injury sites. MAIN METHODS:P-MSCs were isolated from term placenta and characterised under normoxia and hypoxia (2-2.5% O2). Cells were examined for morphology and s...

journal_title：Life sciences

authors： Mathew SA,Chandravanshi B,Bhonde R

更新日期：2017-08-01 00:00:00

abstract：AIMS:C-reactive protein (CRP) is an inflammatory cytokine that has been shown to be an independent predictor of future atherothrombotic events. Hyperactivity of endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by the endothelium, is linked with cardiovascular disease development and progression. ET-1 is s...

journal_title：Life sciences

authors： Dow CA,Templeton DL,Lincenberg GM,Greiner JJ,Stauffer BL,DeSouza CA

更新日期：2016-08-15 00:00:00

abstract：:LH stimulation is mediated by its own receptor at the first step of the cascade, after which intracellular cAMP increases to stimulate the transcription of steroidogenic acute regulatory protein (StAR) in mouse MA-10 Leydig tumor cells. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of ...

journal_title：Life sciences

authors： Tsuchiya M,Inoue K,Matsuda H,Nakamura K,Mizutani T,Miyamoto K,Minegishi T

更新日期：2003-10-17 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (4...

journal_title：Life sciences

authors： Recabarren-Leiva D,Alarcón M

更新日期：2018-01-15 00:00:00

abstract：:This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...

journal_title：Life sciences

authors： Dass PD

更新日期：1983-10-31 00:00:00

abstract：:DHEA improves insulin sensitivity and has anti-obesity effect in animal models and men. However, the molecular mechanisms by which DHEA improves insulin action have not been clearly understood. In the present study, we examined the protein levels and phosphorylation state of insulin receptor (IR), IRS-1 and IRS-2, the...

journal_title：Life sciences

authors： Campbell CS,Caperuto LC,Hirata AE,Araujo EP,Velloso LA,Saad MJ,Carvalho CR

更新日期：2004-11-19 00:00:00

abstract：:Positive inotropic and chronotropic responses of guinea-pig isolated left and right atria to sympathomimetic amines were examined at bath temperatures of 38, 30 or 25 degrees C. The concentration-response curves to isoproterenol and orciprenaline were displaced to the left by cooling, indicating hypothermia-induced su...

journal_title：Life sciences

authors： Chess-Williams RG,Broadley KJ,Duncan C

更新日期：1984-09-03 00:00:00

abstract：:Ischemia-reperfusion of organs such as the kidney produces reactive oxygen and free radical species in tissues and leads to injury of intracellular molecules critical to cell homeostasis. Ischemia-reperfusion affects the NADPH-dependent monooxygenase system including P450 system, which is also a source of reactive oxy...

journal_title：Life sciences

authors： Tamura Y,Imaoka S,Gemba M,Funae Y

更新日期：1997-01-01 00:00:00