L-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: in vivo microdialysis study.

abstract：:Anti-cancer and anti-angiogenesis effects of green tea catechins have been demonstrated. It has been found that chemical modification of tea catechins improves their biological activities. We examined the chemical modification of epicatechin enhanced anti-cancer and anti-angiogenic effects. Epicatechin conjugated with...

journal_title：Life sciences

authors： Matsubara K,Saito A,Tanaka A,Nakajima N,Akagi R,Mori M,Mizushina Y

更新日期：2007-04-03 00:00:00

abstract：:Quercetin, a plant flavonoid, blocks signal transduction pathways by inhibiting 1-phosphatidylinositol 4-kinase (EC 2.7.1.67, PI kinase) and 1-phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68, PIP kinase), resulting in a reduction of inositol 1,4,5-trisphosphate (IP3) concentration which decreases the release of...

journal_title：Life sciences

authors： Yeh YA,Herenyiova M,Weber G

更新日期：1995-01-01 00:00:00

abstract：:The bradykinin-induced sensitization of cutaneous nociceptors to heat was previously shown to be abolished by cyclooxygenase blockade suggesting that endogenous prostaglandins exerted a heat-sensitizing action. The present study aimed at investigating the effects of exogenous prostaglandin E(2) (PGE(2)) and I(2) (PGI(...

journal_title：Life sciences

authors： Derow A,Izydorczyk I,Kuhn A,Reeh PW,Petho G

更新日期：2007-12-14 00:00:00

abstract：:Fissistigma oldhamii (Hemsl.) Merr [F. oldhamii], a traditional Chinese herb medicine, is widely used for treating rheumatoid arthritis (RA) in China. Following bioactivity-guided isolation, a representative immunosuppressive compound with low cytotoxicity, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenam...

journal_title：Life sciences

authors： Hu XD,Zhong XG,Zhang XH,Zhang YN,Zheng ZP,Zhou Y,Tang W,Yang Y,Yang YF,Hu LH,Zuo JP

更新日期：2007-12-14 00:00:00

abstract：:In the field of estrogen therapy breast cancer risk is one of the most controversially discussed topic. Actually, the as yet largest placebo-controlled study, the Women's Health Initiative, rather showed a risk reduction, in contrast to observational studies. In the present study we have investigated the effect of est...

journal_title：Life sciences

authors： Seeger H,Wallwiener D,Mueck AO

更新日期：2006-02-23 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00

abstract：AIMS:The purposes of this study were to determine whether Cervi Pantotrichum Cornu (CPC) has osteogenic activities in human osteoblastic MG-63 cells and to investigate the underlying molecular mechanism. MAIN METHODS:The effects of CPC on alkaline phosphatase activity, collagen synthesis, and calcium deposits were mea...

journal_title：Life sciences

authors： Kim JH,Jung TY,Seo J,Lee S,Kim MG,Leem KH,Lim SC

更新日期：2014-01-14 00:00:00

abstract：:Peptides derived from tryptic hydrolysate of jumbo squid (Dosidicus gigas) skin gelatin were assessed for their antioxidant properties in different in vitro assay systems. The hydrolysate itself exhibited a strong lipid peroxidation inhibition and it was much higher than that of natural antioxidant, alpha-tocopherol. ...

journal_title：Life sciences

authors： Mendis E,Rajapakse N,Byun HG,Kim SK

更新日期：2005-09-09 00:00:00

abstract：:We investigated the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in hemodynamic action of leptin. The effect of leptin (1 mg/kg i.p.) on systolic blood pressure (SBP) was examined in lean rats and in rats made obese by feeding highly palatable diet for either 1 or 3 months. Separate ...

journal_title：Life sciences

authors： Bełtowski J,Wójcicka G,Jamroz-Wiśniewska A

更新日期：2006-05-30 00:00:00

abstract：:Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of gr...

journal_title：Life sciences

authors： Fisher CE,Hughes RN

更新日期：1996-01-01 00:00:00

abstract：:The cardio- and neuroprotective effect of the pyridoindole stobadine (S) is conditioned mainly by its good radical scavenging properties. It has been showed by EPR experiment, that the ultimate product of the reaction of stobadine with hydroxyl radical is the nitroxyl radical. However, for the unsaturated dehydrostoba...

journal_title：Life sciences

authors： Májeková M,Májek P,Mach P

更新日期：1999-01-01 00:00:00

abstract：:We examined the effects of estrogen, 12-O-tetradecanoylphorbol 13 acetate (TPA), and lipopolysaccharide (LPS) on the gene expression of platelet-derived growth factor (PDGF) by the monocyte/macrophage cell line, THP-1. THP-1 cells were exposed to TPA for 48 or 96 hours to induce differentiation. Some were treated with...

journal_title：Life sciences

authors： Shanker G,Sorci-Thomas M,Adams MR

更新日期：1995-01-01 00:00:00

abstract：:Several serotonin (5-HT) receptor antagonists with varying specificities for the 5-HT receptor types, were studied with regard to their effects on blood glucose levels in mice. The non-selective antagonists, metergoline and methysergide, proved to be hyperglycemic at doses commonly used to antagonize 5-HT receptors. I...

journal_title：Life sciences

authors： Wozniak KM,Linnoila M

更新日期：1991-01-01 00:00:00

abstract：:BIM 23014 is a somatostatin analog displaying an increased biological half life due to resistance to enzymatic degradation. This peptide inhibits GH release directly at the level of pituitary somatotrophs. In addition, an action of BIM 23014 at the level of the hypothalamus is possible since somatostatinergic fibers a...

journal_title：Life sciences

authors： Magnan E,Cataldi M,Guillaume V,Conte-Devolx B,Graziani N,Figaroli JC,Thomas F,Chihara K,Oliver C

更新日期：1992-01-01 00:00:00

abstract：:It was demonstrated in the previous study that the microinjection of antisense oligodeoxynucleotide (AS ODN) against mu-opioid receptor (MOR) into periaqueductal gray (PAG) of rat brain selectively decreased the MOR mRNA content in PAG, and the decrease in MOR mRNA content was enhanced by pretreatment of the PAG with ...

journal_title：Life sciences

authors： Oka T,Yoshikawa M,Kobayashi T,Kitamura K,Iwao K,Kobayashi H

更新日期：2001-04-06 00:00:00

abstract：:Leptin regulates glucose, lipid and energy homeostasis as well as feeding behavior, serving as a bridge between peripheral metabolically active tissues and the central nervous system (CNS). Indeed, this adipocyte-derived hormone, whose circulating levels mirror fat mass, not only exerts its anti-obesity effects mainly...

journal_title：Life sciences

authors： Santoro A,Mattace Raso G,Meli R

更新日期：2015-11-01 00:00:00

abstract：:Chronopharmacokinetics deals with the study of the temporal changes in absorption, distribution, metabolism and elimination and thus takes into account the influence of time of administration on these different steps. In the last decade, numerous studies have been devoted to chronokinetics: recent advances will be rev...

journal_title：Life sciences

authors： Bruguerolle B,Lemmer B

更新日期：1993-01-01 00:00:00

abstract：:Studies were performed in the opossum to define the role of the L-arginine-nitric oxide (NO) pathway in lower esophageal sphincter (LES) relaxation to swallowing and vagal stimulation in viv and intramural nerve stimulation in vitro. In vivo, L-NAME, a water soluble NO synthase (NOS) inhibitor, caused antagonism of LE...

journal_title：Life sciences

authors： Yamato S,Saha JK,Goyal RK

更新日期：1992-01-01 00:00:00

abstract：:The recently discovered highly specific delta opioid antagonist H-Tyr-Tic-Phe-Phe-OH (TIPP) was radiolabelled by catalytic tritiation of its precursor [Tyr (3', 5'-I2)1]TIPP. The tritiated ligand labelled rat brain membrane binding sites with a Kd value of 0.64 nM and a Bmax of 82 fmol/mg protein. Binding competition ...

journal_title：Life sciences

authors： Nevin ST,Toth G,Nguyen TM,Schiller PW,Borsodi A

更新日期：1993-01-01 00:00:00

abstract：:Cumulative damage in cells from aged people could lead to a greater fragility against acute oxidative stress. The effects of acute oxidative stress on cell viability, cAMP and cGMP concentrations, and protein synthesis rates were studied in lymphocytes from 25 young and 26 elderly subjects. Lymphocytes were exposed to...

journal_title：Life sciences

authors： Lopez-Hellin J,Garcia-Arumi E,Schwartz S

更新日期：1998-01-01 00:00:00

abstract：:The central interference induced by dexamethasone and RU-38486, (a glucocorticoid receptor antagonist) on morphine antinociception were studied by using the tail flick test in mice. Dexamethasone, injected intracerebrally (i.c.v.) 10 minutes before morphine, dose-dependently reduced morphine antinociception, whereas R...

journal_title：Life sciences

authors： Capasso A,Di Giannuario A,Loizzo A,Pieretti S,Sorrentino L

更新日期：1992-01-01 00:00:00

abstract：:In view of the toxicity of cocaine and recent reports on the antimuscarinic properties of cocaine, the present study evaluated the effects of manipulations in cholinergic neurotransmission on the lethal effects of cocaine. Physostigmine pretreatment significantly altered the lethality of cocaine, increasing the LD 50 ...

journal_title：Life sciences

authors： Witkin JM,Goldberg SR,Katz JL,Kuhar MJ

更新日期：1989-01-01 00:00:00

abstract：:The biochemical changes of the elements of cholinergic neurotransmission (choline acetyltransferase, ChAT; acetylcholinesterase, AChE; butyrylcholinesterase, BuChE; and muscarinic cholinergic receptors, mAChR) as well as the electrolyte content were studied in ischemic lumbar spinal cord segments of newborn pigs. Isch...

journal_title：Life sciences

authors： Tekulics P,Rakonczay Z,Szerdahelyi P,Kása P,Gulya K

更新日期：1990-01-01 00:00:00

abstract：AIMS:In myocardial ischemia-reperfusion (MI/R) injury, impaired autophagy function worsens cardiomyocyte death. AMP-activated protein kinase (AMPK) is a heterotrimeric protein that plays an important role in cardioprotection and myocardial autophagic function. AMPKα1 and α2 are localized primarily in the cytoplasm and ...

journal_title：Life sciences

authors： Wang Y,Yang Z,Zheng G,Yu L,Yin Y,Mu N,Ma H

更新日期：2019-05-15 00:00:00

abstract：:Nitric oxide (NO) is generated from L-arginine by different isoforms of the enzyme nitric oxide synthase (NOS) and is known to be involved in mediating several biological functions, some of which are associated with reproduction. In this study, we examined the ability of the prepubertal ovary to express the inducible ...

journal_title：Life sciences

authors： Srivastava V,Jones BJ,Dookwah H,Hiney JK,Dees WL

更新日期：1997-01-01 00:00:00

abstract：:A simple and sensitive method using high performance liquid chromatography with fluorometric detection has been developed for the identification and quantitation of the endogeneous tryptamine metabolites, indoleacetic acid (IAA) and tryptophol (TOL) in the normal mouse brain. The limits of sensitivity are 5pg for both...

journal_title：Life sciences

authors： Yamada J,Sugimoto Y,Horisaka K

更新日期：1983-11-14 00:00:00

abstract：:Glycated human serum albumin (glc HSA) and glc proteins in back hairs from diabetic rats were deglycated by incubation with hydrazine or aminoguanidine (guanylhydrazine) at physiological temperature (37 degrees C). Glc HSA decreased by 35% with 0.2 M hydrazine at day 20 and by 56% with 0.1 M aminoguanidine at day 10. ...

journal_title：Life sciences

authors： Kobayashi K,Yoshimoto K,Hirauchi K,Uchida K

更新日期：1993-01-01 00:00:00

abstract：:Tissue-type plasminogen activator (tPA) is a key enzyme in the fibrinolysis system and the regulation of its expression has been extensively studied in cultured vascular endothelial cells. Many kinds of supplements including growth factors are needed, however, to keep endothelial cells viable, which leads the culture ...

journal_title：Life sciences

authors： Yoshino A,Suzuki K,Urano T,Aoki K,Takada Y,Kazui T,Takada A

更新日期：2002-02-08 00:00:00

abstract：AIMS:Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown. The aim of this study is to determine whether FF treatment reduces insulin resistance (IR) by alleviating ER stress...

journal_title：Life sciences

authors： Dai F,Jiang T,Bao YY,Chen GJ,Chen L,Zhang Q,Lu YX

更新日期：2016-07-15 00:00:00

abstract：:It has been reported that nitric oxide (NO) is involved in the relaxation mechanism of ginsenoside saponin in various smooth muscle in experimental animals. Although ginsenoside Rg(3) showed both endothelium-dependent and -independent component relaxation in vascular smooth muscle, the action mechanism of the relaxati...

journal_title：Life sciences

authors： Kang YJ,Sohn JT,Chang KC

更新日期：2005-05-20 00:00:00