Theoretical study of the reactivity properties of two forms of stobadine.

abstract：:The heterogeneity of muscarine receptors was examined in two brain regions (cerebral cortex and cerebellum) and in some parasympathetically innervated peripheral tissues (heart, salivary gland and intraorbital lacrimal gland), by in vitro binding techniques. As a tool, we used a new antimuscarinic compound, AF-DX 116 ...

journal_title：Life sciences

authors： Hammer R,Giraldo E,Schiavi GB,Monferini E,Ladinsky H

更新日期：1986-05-05 00:00:00

abstract：:Angiogenesis-targeted therapy of cancer is considered a promising strategy for therapeutic management of cancer progression. Over the last two decades, a few anti-angiogenesis monoclonal antibodies (mAbs) blocking VEGF signaling have been developed and approved by the FDA. The most widely used anti-angiogenesis drug i...

journal_title：Life sciences

authors： Fallah A,Heidari HR,Bradaran B,Sisakht MM,Zeinali S,Molavi O

更新日期：2019-12-15 00:00:00

abstract：:Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4,5-bisphosphate (PIP2) was most strongly affected (50% inhibition at 3 mM phenobarbital); p...

journal_title：Life sciences

authors： Deshmukh DS,Kuizon S,Brockerhoff H

更新日期：1987-11-02 00:00:00

abstract：:Animal studies suggest nicotine and cannabinoids may significantly enhance the therapeutic value of neuroleptics in motor disorders. This was recently demonstrated in humans by the finding that chewing nicotine gum produced striking relief from tics and other symptoms of Tourette syndrome not controlled by neuroleptic...

journal_title：Life sciences

authors： Moss DE,Manderscheid PZ,Montgomery SP,Norman AB,Sanberg PR

更新日期：1989-01-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effects of a mood stabilizer lamotrigine (LMG) on learning and memory processes using Morris water maze (MWM), modified elevated plus maze (mEPM) and passive avoidance (PA) tests. MAIN METHODS:Balb-c mice were used. LMG were injected (20; 40mg/kg, intraperitoneal, i.p....

journal_title：Life sciences

authors： Celikyurt IK,Ulak G,Mutlu O,Akar FY,Erden F,Komsuoglu SS

更新日期：2012-12-17 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS), X-linked severe combined immunodeficiency (SCIDX1), and X-linked agammaglobulinemia (XLA) are severe congenital immunodeficiencies with X-linked inheritance. Although rare, they are all associated with severe infections from early in life, and high morbidity and mortality. Female ca...

journal_title：Life sciences

authors： Wengler GS,Parolini O,Fiorini M,Mella P,Smith H,Ugazio AG,Notarangelo LD

更新日期：1997-01-01 00:00:00

abstract：:Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone re...

journal_title：Life sciences

authors： Porreca F,Dray A

更新日期：1984-06-25 00:00:00

abstract：:Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...

journal_title：Life sciences

authors： Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino F

更新日期：1996-01-01 00:00:00

abstract：AIMS:Smokers have lower plasma concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I) compared with nonsmokers. To determine the molecular basis of this observation, the effect of activation of the aryl hydrocarbon receptor (AhR) on apo A-I gene expression was examined. MAIN METH...

journal_title：Life sciences

authors： Naem E,Alcalde R,Gladysz M,Mesliniene S,Jaimungal S,Sheikh-Ali M,Haas MJ,Wong NC,Mooradian AD

更新日期：2012-07-26 00:00:00

abstract：:Neuropathic pain syndromes respond poorly to opioid treatment. In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino aci...

journal_title：Life sciences

authors： Wu GJ,Wen ZH,Chang YC,Yang SN,Tao PL,Wong CS

更新日期：2006-03-13 00:00:00

abstract：:Preconditioning (PC) is a potential approach to myocardial protection. We hypothesize that brief ischemia or adenosine given prior to an extended period of warm ischemia may prevent myocardial stunning by altering myocardial metabolism. Using a global ischemia model, 19 dogs were subjected to no PC(control), two episo...

journal_title：Life sciences

authors： Phillips AB,Ko W

更新日期：2007-10-13 00:00:00

abstract：:To examine the therapeutic effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on neuronal ischemia-reperfusion injury, we evaluated the neurological score in gerbils subjected to unilateral common carotid occlusion. Using the neurological score method, we selected animals which showed stroke s...

journal_title：Life sciences

authors： Hata R,Matsumoto M,Kitagawa K,Tagaya M,Matsuyama T,Sugita M,Kamada T

更新日期：1995-01-01 00:00:00

abstract：AIMS:Multiple sclerosis (MS) is one of the commonest neurologic disorders globally. LncRNA OIP5-AS1 has been found to be implicated in the etiology of MS. This study was to explore the roles and molecular mechanisms of OIP5-AS1 in the development of MS. MATERIALS AND METHODS:RT-qPCR assay was used to measure expressio...

journal_title：Life sciences

authors： Liu R,Li Y,Zhou H,Wang H,Liu D,Wang H,Wang Z

更新日期：2021-01-27 00:00:00

abstract：:The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels...

journal_title：Life sciences

authors： Polizio AH,Gorzalczany S,Taira C,Peña C

更新日期：2006-07-04 00:00:00

abstract：:The acute dose-dependent effects of epinephrine and cocaine on heart rate and coronary flow rate (CFR) were examined in isolated, perfused (Langendorff) rat hearts from animals: i) pretreated with daily cocaine injections (20 mg/kg/day) for 8 weeks; ii) after 2-day withdrawal from 8-week cocaine pretreatment; iii) veh...

journal_title：Life sciences

authors： Avakian EV,LeRoy M,St John-Allan K,Sayre FW,Malone MH

更新日期：1990-01-01 00:00:00

abstract：:The effect of calcium (Ca2+) on the adenylate cyclase activity and calmodulin level of cerebral cortex was determined in pentobarbital dependent rats and age matched controls. Female Sprague-Dawley rats were made dependent and maintained on pentobarbital by eating a mixture of pentobarbital and rat chow (350 mg pentob...

journal_title：Life sciences

authors： Piascik MT,McNicholas LF

更新日期：1985-07-08 00:00:00

abstract：:Chronopharmacokinetics deals with the study of the temporal changes in absorption, distribution, metabolism and elimination and thus takes into account the influence of time of administration on these different steps. In the last decade, numerous studies have been devoted to chronokinetics: recent advances will be rev...

journal_title：Life sciences

authors： Bruguerolle B,Lemmer B

更新日期：1993-01-01 00:00:00

abstract：:A synthetic peptide corresponding to a sequence of 26 amino acids contained in endogenous rat atrial natriuretic factor (ANF), was infused into one renal artery of anesthetized dogs for a comprehensive in vivo evaluation of the renal and systemic effects of pure ANF. The results proved conclusively that ANF acted dire...

journal_title：Life sciences

authors： Seymour AA,Blaine EH,Mazack EK,Smith SG,Stabilito II,Haley AB,Napier MA,Whinnery MA,Nutt RF

更新日期：1985-01-07 00:00:00

abstract：AIMS:We previously reported that cysteinyl leukotriene receptor 2 (CysLT(2)) mediates ischemic astrocyte injury, and leukotriene D(4)-activated CysLT(2) receptor up-regulates the water channel aquaporin 4 (AQP4). Here we investigated the mechanism underlying CysLT(2) receptor-mediated ischemic astrocyte injury induced ...

journal_title：Life sciences

authors： Qi LL,Fang SH,Shi WZ,Huang XQ,Zhang XY,Lu YB,Zhang WP,Wei EQ

更新日期：2011-01-03 00:00:00

abstract：:Nitric oxide (NO) plays an important role in glucose and lipid metabolism. We previously reported that NO synthesis inhibitors, such as NG-nitro-L-arginine methyl ester (L-NAME), deteriorate insulin sensitivity and lipid metabolism, while the addition of L-arginine reverses this deterioration. L-arginine is a precurso...

journal_title：Life sciences

authors： Kawano T,Nomura M,Nisikado A,Nakaya Y,Ito S

更新日期：2003-10-24 00:00:00

abstract：:An increased level of melanin is characteristic of a large number of skin diseases, including acquired hyperpigmentation conditions such as melasma, post inflammatory melanoderma, and solar lentigo. Thus, there is an increasing need for the development of depigmenting agents. In order to evaluate the depigmenting capa...

journal_title：Life sciences

authors： Lee J,Jung K,Kim YS,Park D

更新日期：2007-06-27 00:00:00

abstract：:Iron imbalance has been implicated in oxidative injury associated with many brain diseases. The present study investigated the importance of iron location in hydroxyl radical (.OH) generation and the link between .OH production evaluated by the salicylate method and lipid peroxidation monitored by thiobarbituric acid-...

journal_title：Life sciences

authors： Demougeot C,Marie C,Beley A

更新日期：2000-06-16 00:00:00

abstract：:Activin A is a member of the transforming growth factor-beta superfamily that exerts its diverse biological effects through bindings to activin specific transmembrane serine/threonine kinase receptors. The fibroblast-mediated contraction of a collagen gel is thought to be a model of part of the wound-repair response a...

journal_title：Life sciences

authors： Ohga E,Matsuse T,Teramoto S,Ouchi Y

更新日期：2000-03-01 00:00:00

abstract：:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...

journal_title：Life sciences

authors： Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

更新日期：2003-10-10 00:00:00

abstract：:The ability of selective mu- ([D-Ala2, NHPhe4, Gly-ol]enkephalin: DAMGO), delta1- ([D-Pen2, Pen5]enkephalin: DPDPE) and delta2- ([D-Ala2]deltorphin II: DELT II) opioid receptor agonists to activate G-proteins in the midbrain and forebrain of mice and rats was examined by monitoring the binding of guanosine-5'-O-(3-[35...

journal_title：Life sciences

authors： Tsuji M,Narita M,Mizoguchi H,Narita M,Ohsawa M,Kamei J,Nagase H,Takeda H,Matsumiya T,Tseng LF

更新日期：1999-01-01 00:00:00

abstract：AIMS:Glycation of proteins leads to the formation of advanced glycation end products (AGEs, which have significant role in the pathophysiology of diabetes complications. d-ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the generation of AGEs. Glycation also r...

journal_title：Life sciences

authors： Akhter F,Khan MS,Alatar AA,Faisal M,Ahmad S

更新日期：2016-04-15 00:00:00

abstract：:The cellular electrophysiology of left ventricular preparations from guinea pig hearts was studied 1 hour, 24 hours, and 4-6 weeks after myocardial infarction produced by 6-8 single ties of the distal left coronary artery system or after sham operation. Microelectrode recordings were used to monitor cells from the end...

journal_title：Life sciences

authors： Gaide MS,Cameron JS,Altman CB,Myerburg RJ,Bassett AL

更新日期：1985-06-24 00:00:00

abstract：:Responses to [Mpr14]-ADM(14-50), a novel analog of adrenomedullin, were investigated in the hindlimb vascular bed of the cat under conditions of controlled blood flow. Intraarterial injections of [Mpr14]-rADM(14-50) in doses of 0.003-1 nmol caused dose-related decreases in hindlimb perfusion pressure. In terms of rela...

journal_title：Life sciences

authors： Champion HC,Duperier CD,Fitzgerald WE,Lambert DG,Murphy WA,Coy DH,Kadowitz PJ

更新日期：1996-01-01 00:00:00

abstract：AIMS:Oxaliplatin (l-OHP) is a key drug in therapeutic regimens for metastatic or advanced-stage colorectal cancer, but causes peripheral neuropathy as a dose-limiting adverse effect. It is reported that this peripheral neuropathy results from l-OHP accumulation in dorsal root ganglion (DRG) neurons, and that one of the...

journal_title：Life sciences

authors： Nishida K,Takeuchi K,Hosoda A,Sugano S,Morisaki E,Ohishi A,Nagasawa K

更新日期：2018-08-15 00:00:00

abstract：:The binding of the D2-like agonists, (+)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin (7-OH-DPAT) and [3H]pramipexole (2-amino-4,5,6-tetrahydro-6-propylaminobenzthiazole; MIRAPEX) were determined in membranes from adult male Sprague-Dawley and Fischer-344 rats. Saturation analysis, which optimized binding to D3 recep...

journal_title：Life sciences

authors： Wallace DR,Owens J,Booze RM

更新日期：1998-01-01 00:00:00