Abstract：
:Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells from normal rats. An increased production of lactate was also observed. Phosphofructokinase-1 (PFK-1) and phosphofructokinase-2 (PFK-2) activities were enhanced in cells from diabetic rats compared with those from normal rats. [U-14C]glucose incorporation into glycogen was also increased in cells from diabetic rats and the 14CO2 liberation was lesser than in cells from normal animals. From these data it may be concluded that the response of thymocytes to streptozotocin-induced diabetes is similar to that observed in other extrahepatic tissues.
journal_name
Life Scijournal_title
Life sciencesauthors
Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino Fdoi
10.1016/0024-3205(95)02312-7subject
Has Abstractpub_date
1996-01-01 00:00:00pages
477-84issue
6eissn
0024-3205issn
1879-0631pii
0024320595023127journal_volume
58pub_type
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