Arachidonic acid is involved in the regulation of hCG induced steroidogenesis in rat Leydig cells.

abstract：:Short-chain fatty acids (SCFA) are produced by fermentation of water-soluble fiber by anaerobic bacteria in the large bowel. Fiber-rich diets decrease the risk of developing inflammatory bowel disease (IBD) and butyrate enemas are effective as a therapy in some patients. Crohn's disease, one form of IBD, appears to in...

journal_title：Life sciences

authors： Cavaglieri CR,Nishiyama A,Fernandes LC,Curi R,Miles EA,Calder PC

更新日期：2003-08-15 00:00:00

abstract：AIMS:GnRH-DFF40 (gonadotropin releasing hormone-DNA fragmentation factor 40) humanized recombinant immunotoxin serves as a prospective candidate for targeted therapy of malignancies with over-expressed gonadotropin releasing hormone receptor (GnRHR). In this study, we attempted to generate a GnRH-based chimeric protein...

journal_title：Life sciences

authors： Barazesh M,Mohammadi S,Jalili S,Kavousipour S,Faraji SN,Mokarram P,Pirhadi S

更新日期：2021-01-15 00:00:00

abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...

journal_title：Life sciences

authors： Yasmineh WG,Tsai MY,Theologides A

更新日期：1995-01-01 00:00:00

abstract：:Though chemokines of the CXC family are thought to play key roles in neoplastic transformation and tumor invasion, information about CXC chemokines in prostate cancer is sparse. To evaluate the involvement of CXC chemokines in prostate cancer, we analyzed the CXC coding mRNA of both chemokine ligands (CXCL) and chemok...

journal_title：Life sciences

authors： Engl T,Relja B,Blumenberg C,Müller I,Ringel EM,Beecken WD,Jonas D,Blaheta RA

更新日期：2006-03-13 00:00:00

abstract：:Male Sprague-Dawley rats were given a single electroconvulsive shock (ECS) on alternate days and sacrificed 48 hrs after 1, 3, or 5 seizures. The content of TRH in hippocampus, pyriform cortex and amygdala was increased 2.5-fold, 5.4-fold and 4.3-fold respectively, 48 hrs. after 3 alternate-day electroconvulsive shock...

journal_title：Life sciences

authors： Kubek MJ,Meyerhoff JL,Hill TG,Norton JA,Sattin A

更新日期：1985-01-28 00:00:00

abstract：:Electrically evoked release of dopamine from the caudate nucleus is reduced by the dopamine receptor agonists, apomorphine and bromocriptine, and facilitated by neuroleptic drugs, which act as dopamine autoreceptor antagonists. The potencies of chlorpromazine, fluphenazine, levomepromazine and their hydroxy-metabolite...

journal_title：Life sciences

authors： Nowak JZ,Arbilla S,Dahl SG,Langer SZ

更新日期：1990-01-01 00:00:00

abstract：AIMS:The mechanisms underlying the fetal origin of renal disease remains unknown. This study aimed to investigate the profiles of ion channel and transporter proteins in the fetal kidney in fetal growth restriction (FGR)rats, and to explore their association with the fetal origin of renal disease. MAIN METHODS:An FGR ...

journal_title：Life sciences

authors： Guo Y,Lu Y,Wang J,Zhu L,Liu X

更新日期：2020-10-15 00:00:00

abstract：:The mechanism of the antithrombotic effects of heparin and the synthetic antithrombin agent argatroban was evaluated in a dog model. Thrombus formation following balloon injury was evaluated by angioscopy in the right iliac arteries of 20 dogs to serve as a control. After the evaluation of the growth of thrombus on th...

journal_title：Life sciences

authors： Tomaru T,Kawano HA,Tsujiuchi Y,Suzuki J,Nakajima T,Uchida Y

更新日期：2005-10-07 00:00:00

abstract：:In the normal adult brain, glucose provides 90% of the energy requirement, as well as substrate for nucleic acid and lipid synthesis. We have previously observed that ethanol impairs hexose uptake by rat astrocytes in culture. In the present study, male Sprague-Dawley rats, 200-250 g, were fed liquid diet in which 36%...

journal_title：Life sciences

authors： Singh SP,Srivenugopal KS,Yuan XH,Jiang F,Snyder AK

更新日期：1993-01-01 00:00:00

abstract：:The molecular dynamics (MD) simulations study in the formation of the complex between compound SWR-0342SA and beta-ARs suggested that upon binding SWR-0342SA stimulates receptor activation through residues network (Asp104, Leu335 in beta(1)-AR; Asp117, Ser209, Leu303, Ser191 in beta(3)-AR) in an active conformation st...

journal_title：Life sciences

authors： Ahmed M,Ishiguro M,Nagatomo T

更新日期：2006-03-20 00:00:00

abstract：:Stem cells have potential to develop into numerous cell types, thus they are good cell source for tissue engineering. As an external physical signal, material stiffness is capable of regulating stem cell fate. Biomaterial stiffness is an important parameter in tissue engineering. We summarize main measurements of mate...

journal_title：Life sciences

authors： Lv H,Wang H,Zhang Z,Yang W,Liu W,Li Y,Li L

更新日期：2017-06-01 00:00:00

abstract：:23-Hydroxybetulinic acid, a derivative of betulinic acid, was investigated for its apoptotic effect and the associated telomerase activity in human leukemia HL-60 cells. Apoptosis and bcl-2 were determined by flow cytometry analysis. A PCR-based telomeric repeat amplification protocol assay was used to detect telomera...

journal_title：Life sciences

authors： Ji ZN,Ye WC,Liu GG,Hsiao WL

更新日期：2002-11-22 00:00:00

abstract：:This study is aimed to investigate the effect of the prolonged intake of conspicuous amounts of licorice (LE), or its natural constituent glycyrrhizin (G) on murine liver CYP-catalyzed drug metabolism. For this purpose the modulation of the regio- and stereo-selective hydroxylation of testosterone, together with the u...

journal_title：Life sciences

authors： Paolini M,Pozzetti L,Sapone A,Cantelli-Forti G

更新日期：1998-01-01 00:00:00

abstract：UNLABELLED:Isolation of meiotic arrested oocytes from mammalian ovaries involves a resumption of the meiosis. Studying the effect of FSH on this process it was found that doses up to of 0.1 IU/ml did not maintain the meiotic arrest in hamster oocytes in pre-antral follicles during static incubation conditions. However,...

journal_title：Life sciences

authors： Goverde HJ,van de Venne WP

更新日期：1994-01-01 00:00:00

abstract：:The effects of the novel anticonvulsant felbamate, which binds to the 5-7 dichlorokynurenic binding sites, were tested towards the CA1 epileptiform activity induced in rat hippocampal slices by kainic acid. The effects of the kynurenic acid derivatives 7-chlorokynurenic acid and 5-7 dichlorokynurenic acid and of the N...

journal_title：Life sciences

authors： Domenici MR,Marinelli S,Sagratella S

更新日期：1996-05-24 00:00:00

abstract：AIMS:Naturally-derived farnesol has been reported for its chemopreventive and chemotherapeutic efficacy in various cancers. However, the mechanism of action of farnesol is still to be elucidated. The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated ...

journal_title：Life sciences

authors： Chaudhary SC,Alam MS,Siddiqui MS,Athar M

更新日期：2009-07-31 00:00:00

abstract：:Nitric oxide (NO) is a potent regulator in the cardiovascular system; it is generated by the nitric oxide synthase (NOS) family of proteins. NO produced in endothelial cells plays a crucial role in vascular functions. The aim of this study was to clarify the effect of diabetes on aortic NO synthesis in a model of gene...

journal_title：Life sciences

authors： Ibrahim MA,Kanzaki T,Yamagata S,Satoh N,Ueda S

更新日期：2005-07-15 00:00:00

abstract：:Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects ...

journal_title：Life sciences

authors： Rahmani S,Pour Khalili N,Khan F,Hassani S,Ghafour-Boroujerdi E,Abdollahi M

更新日期：2018-12-01 00:00:00

abstract：:We recently labeled with carbon-11, a high affinity, selective, 5-HT3 receptor (5-HT3R) ligand, S21007, for potential positron emission tomography (PET) applications. To evaluate the in vivo binding properties of [11C]S21007, its brain regional distribution, tissue and plasma pharmacokinetics and plasma metabolisation...

journal_title：Life sciences

authors： Besret L,Dauphin F,Guillouet S,Dhilly M,Gourand F,Blaizot X,Young AR,Petit-Taboué MC,Mickala P,Barbelivien A,Rault S,Barré L,Baron JC

更新日期：1998-01-01 00:00:00

abstract：:Leukocyte interactions with endothelial cell monolayers (ECM) and smooth muscle cells (SMC) play an important role during inflammatory processes. Several studies describe an inhibitory effect of dexamethasone on polymorphonuclear leukocytes (PMNL), endothelial cell function, and interleukin-1 (IL-1) release. Aim of th...

journal_title：Life sciences

authors： Hofbauer R,Gmeiner B,Handler S,Speiser W,Kapiotis S,Frass M

更新日期：1999-01-01 00:00:00

abstract：:Myelin basic protein and phosphatidylinositol-4-phosphate are phosphorylated in vitro by ATP and solubilized rat brain myelin. When both substrates are present together, the rate of phosphorylation of each is increased about eight-fold. It appears likely that the phosphate turnover of myelin basic protein and of phosp...

journal_title：Life sciences

authors： Deshmukh DS,Kuizon S,Brockerhoff H

更新日期：1984-01-16 00:00:00

abstract：:The metabolism and disposition of N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA) was studied by utilizing rat liver slices as well as by intravenous pharmacokinetic studies in rats. In the liver slice experiments, N-OH MDA (16 micrograms/ml) was incubated with rat liver slices and the disappearance of N-OH MDA and...

journal_title：Life sciences

authors： Ravis WR,Valaer AK,Brzozowski D,Clark CR

更新日期：1994-01-01 00:00:00

abstract：:The present study examines the signal transduction mechanism that is involved in the growth of vascular smooth muscle cells exposed to 4-hydroxynonenal (HNE) in vitro. This aldehyde component of oxidized low-density lipoprotein has been identified in atherosclerotic lesion. Exposure to HNE caused ERK, JNK, and p38 MAP...

journal_title：Life sciences

authors： Kakishita H,Hattori Y

更新日期：2001-06-29 00:00:00

abstract：:We contrast the effects of three intermediate electron acceptors (IEAs) on the highly quantitative ESTA bioassay for human growth hormone. This is a microculture tetrazolium assay based upon the in vitro reduction of the tetrazolium salt MTT, by Nb2 cells which have been activated with hGH. Each of the IEAs influenced...

journal_title：Life sciences

authors： Goodwin CJ,Holt SJ,Downes S,Marshall NJ

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Doxorubicin, as an effective chemotherapeutic drug, is commonly used for combating various solid and hematological tumors. However, doxorubicin-induced cardiotoxicity is considered as a serious adverse effect, and it limits the clinical use of this chemotherapeutic drug. The use of melatonin can lead to a decre...

journal_title：Life sciences

authors： Najafi M,Hooshangi Shayesteh MR,Mortezaee K,Farhood B,Haghi-Aminjan H

更新日期：2020-01-15 00:00:00

abstract：:The characteristics and distribution of putative thyrotropin releasing hormone (TRH) receptors were studied in rat central nervous system using the TRH analogue 3H-(3MeHis2)TRH as a radiolabeled ligand. The analogue had a dissociation constant of 2.3 +/- 0.2 nM and a receptor density of 34 +/- 2 fm/mg protein in whole...

journal_title：Life sciences

authors： Simasko SM,Horita A

更新日期：1982-05-24 00:00:00

abstract：:SR 142801 is the first potent and selective non-peptide antagonist of the tachykinin NK3 receptor. It inhibited [MePhe7]NKB binding to its receptor from various species, including humans. SR 142801 was a competitive antagonist of [MePhe7]NKB-mediated contractions of guinea-pig ileum and inhibited the acetylcholine rel...

journal_title：Life sciences

authors： Emonds-Alt X,Bichon D,Ducoux JP,Heaulme M,Miloux B,Poncelet M,Proietto V,Van Broeck D,Vilain P,Neliat G

更新日期：1995-01-01 00:00:00

abstract：:Sleep is crucial to improve athlete performance and their circadian rhythm, but sleep patterns may be disturbed because athletes participate in several competitions. In addition, intensive training programs can cause muscle pain and psychological stress in athletes, resulting in a lack of sleep. Sleep also plays a cri...

journal_title：Life sciences

authors： Yang DF,Shen YL,Wu C,Huang YS,Lee PY,Er NX,Huang WC,Tung YT

更新日期：2019-10-15 00:00:00

abstract：:In the present report, the putative effect of a single electrical stimulation (75, 150 or 300 microA) to the baso-lateral amygdala (BLA) nucleus was assessed in shock probe defensive burying behavior test (DB) and elevated plus maze (EPM). These models have been used for measuring anxiety levels and screening putative...

journal_title：Life sciences

authors： Saldívar-González JA,Posadas-Andrews A,Rodríguez R,Gómez C,Hernández-Manjarrez ME,Ortiz-León S,Martínez-Pineda A,Gómez-Laguna D,Salgado V,Manjarrez J,Alvarado R

更新日期：2003-01-03 00:00:00

abstract：:Specific 125I-CCK receptor binding was significantly increased in brain tissue taken from guinea pig or mouse following chronic (2-3 week) daily administration of haloperidol (2-3 mg/kg/day). Scatchard analysis indicated the increase in CCK binding was due to an increased receptor number (B max) with no change in affi...

journal_title：Life sciences

authors： Chang RS,Lotti VJ,Martin GE,Chen TB

更新日期：1983-02-21 00:00:00