Abstract:
:Stem cells have potential to develop into numerous cell types, thus they are good cell source for tissue engineering. As an external physical signal, material stiffness is capable of regulating stem cell fate. Biomaterial stiffness is an important parameter in tissue engineering. We summarize main measurements of material stiffness under different condition, then list and compare three main methods of controlling stiffness (material amount, crosslinking density and photopolymeriztion time) which interplay with one another and correlate with stiffness positively, and current advances in effects of biomaterial stiffness on stem cell fate. We discuss the unsolved problems and future directions of biomaterial stiffness in tissue engineering.
journal_name
Life Scijournal_title
Life sciencesauthors
Lv H,Wang H,Zhang Z,Yang W,Liu W,Li Y,Li Ldoi
10.1016/j.lfs.2017.04.014subject
Has Abstractpub_date
2017-06-01 00:00:00pages
42-48eissn
0024-3205issn
1879-0631pii
S0024-3205(17)30163-7journal_volume
178pub_type
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