A systematical comparison of anti-angiogenesis and anti-cancer efficacy of ramucirumab, apatinib, regorafenib and cabozantinib in zebrafish model.

abstract：AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...

journal_title：Life sciences

authors： Tsuchiya M,Niijima-Yaoita F,Yoneda H,Chiba K,Tsuchiya S,Hagiwara Y,Sasaki K,Sugawara S,Endo Y,Tan-No K,Watanabe M

更新日期：2014-05-08 00:00:00

abstract：:Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...

journal_title：Life sciences

authors： Riddle MA,Shaywitz BA,Leckman JF,Anderson GM,Shaywitz SE,Hardin MT,Ort SI,Cohen DJ

更新日期：1986-03-17 00:00:00

abstract：:BIM 23014 is a somatostatin analog displaying an increased biological half life due to resistance to enzymatic degradation. This peptide inhibits GH release directly at the level of pituitary somatotrophs. In addition, an action of BIM 23014 at the level of the hypothalamus is possible since somatostatinergic fibers a...

journal_title：Life sciences

authors： Magnan E,Cataldi M,Guillaume V,Conte-Devolx B,Graziani N,Figaroli JC,Thomas F,Chihara K,Oliver C

更新日期：1992-01-01 00:00:00

abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...

journal_title：Life sciences

authors： Matsui M,Yamada S,Oki T,Manabe T,Taketo MM,Ehlert FJ

更新日期：2004-11-05 00:00:00

abstract：:The leukotriene (LT) synthesis inhibitors BAY x1005 and MK-886 were evaluated in human lung parenchyma challenged with an anti-IgE. The anti-IgE-induced LTE4 release was time- and dose-dependent. Treatment of the parenchyma with indomethacin (3 microM) prior to anti-IgE challenge inhibited the 6-keto prostaglandin F1 ...

journal_title：Life sciences

authors： Gorenne I,Alaoui HS,Gascard JP,Labat C,Norel X,De Montpreville V,Brink C

更新日期：1996-01-01 00:00:00

abstract：:Sodium spirulan (Na-SP) is a sulfated polysaccharide with M(r) approximately 220,000 isolated from the blue-green alga Spirulina platensis. The polysaccharide consists of two types of disaccharide repeating units, O-hexuronosyl-rhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate gr...

journal_title：Life sciences

authors： Kaji T,Okabe M,Shimada S,Yamamoto C,Fujiwara Y,Lee JB,Hayashi T

更新日期：2004-03-26 00:00:00

abstract：:Activin A is a member of the transforming growth factor-beta superfamily that exerts its diverse biological effects through bindings to activin specific transmembrane serine/threonine kinase receptors. The fibroblast-mediated contraction of a collagen gel is thought to be a model of part of the wound-repair response a...

journal_title：Life sciences

authors： Ohga E,Matsuse T,Teramoto S,Ouchi Y

更新日期：2000-03-01 00:00:00

abstract：:We measured the concentration of immunoreactive (IR) hEGF in various body fluids by radioimmunoassay (RIA) and evaluated its size heterogeneity by size exclusion high performance liquid chromatography combined with RIA or with time-resolved immunofluorometric assay (TR-IFMA). Mean concentration was 80 ng/ml in urine, ...

journal_title：Life sciences

authors： Pesonen K,Viinikka L,Koskimies A,Banks AR,Nicolson M,Perheentupa J

更新日期：1987-06-29 00:00:00

abstract：AIMS:7-Ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxidized low-density lipoprotein (oxLDL), has been reported to be a crucial ligand of beta2-glycoprotein I (β(2)-GPI), and plays a potential role in the development of atherosclerosis (AS), however, the role of the sole oxLig-1 in the development of...

journal_title：Life sciences

authors： Huang Z,Li W,Wang R,Zhang F,Chi Y,Wang D,Liu Z,Zhang Y,Matsuura E,Liu Q

更新日期：2010-11-20 00:00:00

abstract：:Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T ce...

journal_title：Life sciences

authors： Tsao CW,Lin YS,Cheng JT

更新日期：1998-01-01 00:00:00

abstract：:Substrate stiffness is essential for cell functions, but the mechanisms by which cell sense mechanical cues are still unclear. Here we show that the frequency and the amplitude of spontaneous Ca2+ oscillations were greater in chick cardiomyocytes cultured on the stiff substrates than that on the soft substrates. The s...

journal_title：Life sciences

authors： Liu S,Gao X,Wu X,Yu Y,Yu Z,Zhao S,Zhao H

更新日期：2019-10-15 00:00:00

abstract：AIMS:Baicalein is a widely used Chinese herbal medicine extracted from Labiatae plants Scutellaria baicalensis Georgi's dry root, which has multiple pharmacological activities. However, the precise mechanism of baicalein against myocardial remodeling remains poorly understood. The aim of our study was to investigate th...

journal_title：Life sciences

authors： Zhao F,Fu L,Yang W,Dong Y,Yang J,Sun S,Hou Y

更新日期：2016-01-15 00:00:00

abstract：:This study assessed the effects of acute intravenous L-tryptophan (neutral amino acid precursor for serotonin) administration on cocaine-induced dopaminergic responses. Male Sprague-Dawley rats were surgically implanted with guide cannulas in the nucleus accumbens 5 days prior to the study and with vascular catheters ...

journal_title：Life sciences

authors： Molina PE,Ahmed N,Gatley J,Volkow ND,Abumrad NN

更新日期：2001-09-07 00:00:00

abstract：:Data reviewed here indicate that acute and chronic ethanol ingestion induce a decrease in the concentration of GSH and an increase in lipoperoxidation in the liver both in experimental animals and in man, changes that are closely interrelated GSH depletion is suggested to be due to an oxidation in the liver tissue and...

journal_title：Life sciences

authors： Videla LA,Valenzuela A

更新日期：1982-11-29 00:00:00

abstract：:In order to further elucidate a possible role of neuropeptides and GABA in the pathogenesis of febrile convulsions, we studied changes of immunoreactive-arginine vasopressin (IR-AVP), IR-somatostatin (IR-SRIF) and gamma-aminobutyric acid (GABA) in the rat brain after febrile convulsions induced by ultra-red light (UR)...

journal_title：Life sciences

authors： Nagaki S,Nagaki S,Minatogawa Y,Sadamatsu M,Kato N,Osawa M,Fukuyama Y

更新日期：1996-01-01 00:00:00

abstract：:Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detected by metabolic labeling, Western blot analyses and immunofluorescence...

journal_title：Life sciences

authors： Forsman T,Lautala P,Lundström K,Monastyrskaia K,Ouzzine M,Burchell B,Taskinen J,Ulmanen I

更新日期：2000-10-06 00:00:00

abstract：:Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. In a previous report we found that intracerebroventricular administration of nitric oxide (NO) generator sodium nitroprusside (SNP) to conscious male rats inhibited dose-dependently the TH activity of the median eminence (ME)....

journal_title：Life sciences

authors： Abreu P,Llorente E,Sánchez JJ,González MC

更新日期：2000-09-08 00:00:00

abstract：:Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no de...

journal_title：Life sciences

authors： Römer D,Büscher HH,Hill RC,Maurer R,Petcher TJ,Zeugner H,Benson W,Finner E,Milkowski W,Thies PW

更新日期：1982-09-20 00:00:00

abstract：:Protein tyrosine phosphorylation is prevalent throughout the nervous system. It has been implicated to play an important role in the development and maintenance of neuronal functions. In the past few years significant advances have been made in our understanding of the molecular mechanisms of synapse formation and syn...

journal_title：Life sciences

authors： Mei L,Si J

更新日期：1995-01-01 00:00:00

abstract：:This in vitro study was conducted to determine whether tachyphylaxis of guinea pig airway to furosemide occurs under conditions that produce tachyphylaxis to the beta 2-adrenoceptor agonist, salbutamol. Isometric tension was measured in tracheal rings bathed in HEPES buffer from 4-6 d newborn guinea pigs of either sex...

journal_title：Life sciences

authors： Iwamoto LM,Wilson VL,Lavallee SL,Fujiwara N,Ayau EL,Nakamura KT

更新日期：1996-01-01 00:00:00

abstract：:Male, 5 months old, massively obese, spontaneously hypertensive rats (Obese/SHR) were given 10 mg alloxan/100 g b.w., s.c., to induce diabetes. Control Obese and non-obese/SHR were given saline. Insulin therapy was withheld. All of the animals were killed at 6 months of age. Alloxan caused a slight but statistically s...

journal_title：Life sciences

authors： Wexler BC,Mc Murtry JP

更新日期：1983-09-12 00:00:00

abstract：:It is known that K(ATP) channel openers inhibit the release and refilling of Ca(2+) from intracellular stores. The present study was designed to test the effects of levcromakalim in human umbilical artery (HUA) rings stimulated by serotonin (5-HT) and KCl in Ca-free medium. Umbilical cords were obtained at vaginal or ...

journal_title：Life sciences

authors： Tufan H,Ayan-Polat B,Tecder-Unal M,Polat G,Kayhan Z,Oğüş E

更新日期：2003-02-07 00:00:00

abstract：:Physalis angulata and P. peruviana are herbs widely used in folk medicine. In this study, the aqueous and ethanol extracts prepared from the whole plant of these species were evaluated for their antihepatoma activity. Using XTT assay, three human hepatoma cells, namely Hep G2, Hep 3B and PLC/PRF/5 were tested. The res...

journal_title：Life sciences

authors： Wu SJ,Ng LT,Chen CH,Lin DL,Wang SS,Lin CC

更新日期：2004-03-05 00:00:00

abstract：AIMS:Antitumour effects of pentapeptide (LH) derived from donkey serum albumin hydrolysates were tested against tumour cells both in vitro and in vivo. The mechanism of LH induced tumour cell apoptosis was investigated. MAIN METHODS:Human promyelocytic leukaemia cells (HL 60) were cultured to observe inhibition in vit...

journal_title：Life sciences

authors： Li H,Zhong J,Huang M,Li Z,Rao P

更新日期：2013-05-20 00:00:00

abstract：AIMS:To characterize the effects of a calorie matched high-fat diet (HFD) on spontaneous physical activity (SPA), body weight, inflammatory status and expression of genes related to energy homeostasis in hypothalamus of mice. MAIN METHODS:C57Bl/6 mice (n=5 per group) were fed a control diet (16.5% calories from fat) -...

journal_title：Life sciences

authors： Moretto TL,Benfato ID,de Carvalho FP,Barthichoto M,Le Sueur-Maluf L,de Oliveira CAM

更新日期：2017-06-15 00:00:00

abstract：:Previous behavioral studies on triazolam (TZ), which are small in number, could only speculate about tolerance to the anxiolytic effect of TZ, as the experiments did not cover sufficient time (of 4 to 7 days) for tolerance to develop. Therefore longer time for chronic TZ administration is used. We investigated the eff...

journal_title：Life sciences

authors： Aburawi SM,Elhwuegi AS,Ahmed SS,Saad SF,Attia AS

更新日期：2003-10-31 00:00:00

abstract：:Heat shock protein 70 (Hsp70) is capable of protecting cells, tissues, organs, and animals from a subsequent, normally lethal heating, as well as from numerous disease states. Therefore, it would be of great therapeutic benefit to discover compounds that are clinically safe yet able to induce Hsp70 in patients. Carben...

journal_title：Life sciences

authors： Nagayama S,Jono H,Suzaki H,Sakai K,Tsuruya E,Yamatsu I,Isohama Y,Miyata T,Kai H

更新日期：2001-11-02 00:00:00

abstract：:Examination was made of the effects of 17 synthetic and naturally occurring flavonoids on human lymphocyte proliferation in the presence of concanavalin A as a mitogen. Twelve of the flavonoids examined were mono-hydroxy or methoxy derivatives. The mitogen-induced response of lymphocytes was evaluated from the extent ...

journal_title：Life sciences

authors： Hirano T,Oka K,Kawashima E,Akiba M

更新日期：1989-01-01 00:00:00

abstract：:Comparison of neuronal and non-neuronal membrane transport of, and neuroexcitation by, the dicarboxylic amino acids bring out provocative similarities in structural selectivity, and hence in the strategies for studying them. Parallel anomalies in stereoselectivity show for both phenomena that the recognition sites are...

journal_title：Life sciences

authors： Christensen HN,Makowske M

更新日期：1983-12-05 00:00:00

abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...

journal_title：Life sciences

authors： Ubeda A,Díaz-Enriquez M,Martínez-Pascual MA,Parreño A

更新日期：1997-01-01 00:00:00