The role of vasopressin, somatostatin and GABA in febrile convulsion in rat pups.

abstract：AIMS:The aim of this study is to determine whether Nkx2.5 transfection of transplanted bone marrow mesenchymal stem cells (MSCs) improves the efficacy of treatment of adriamycin-induced heart failure in a rat model. MAIN METHODS:Nkx2.5 was transfected in MSCs by lentiviral vector transduction. The expressions of Nkx2....

journal_title：Life sciences

authors： Deng B,Wang JX,Hu XX,Duan P,Wang L,Li Y,Zhu QL

更新日期：2017-08-01 00:00:00

abstract：:The systemic administration of neurotensin (NT) dose-dependently increased plasma adrenocorticotropin (ACTH) concentration in rats, and this effect was annulled by (alpha-helical)-CRH9-41, an antagonist of corticotropin-releasing hormone (CRH). The systemic administration of [D-Trp11]-neurotensin (NT-A), a specific NT...

journal_title：Life sciences

authors： Nussdorfer GG,Malendowicz LK,Meneghelli V,Mazzocchi G

更新日期：1992-01-01 00:00:00

abstract：:Decidualization of endometrial tissues, which is essential for implantation and the continuation of pregnancy, is induced by pituitary hormones that are regulated by gonadotropin releasing hormone (GnRH). Our objective was to determine the role of a direct action of GnRH on endometrial tissues by comparing the charact...

journal_title：Life sciences

authors： Takeuchi S,Futamura N,Minoura H,Toyoda N

更新日期：1998-01-01 00:00:00

abstract：:We used in vitro quantitative autoradiography to investigate changes in neurotransmitter receptor binding, including muscarinic cholinergic, PCP, GABAA, benzodiazepine, D1 and 5-HT2A receptor, in the brains of aged rats, compared with such binding in young rats. Scatchard analysis revealed that the maximal number of b...

journal_title：Life sciences

authors： Nabeshima T,Yamada K,Hayashi T,Hasegawa T,Ishihara S,Kameyama T,Morimasa T,Kaneyuki T,Shohmori T

更新日期：1994-01-01 00:00:00

abstract：:To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ...

journal_title：Life sciences

authors： Hou YC,Hsiu SL,Ching H,Lin YT,Tsai SY,Wen KC,Chao PD

更新日期：2005-01-21 00:00:00

abstract：:This study was designed to investigate the effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase N(G), N(G)-asymmetric dimethylarginine (ADMA) in patients and rats with diabetes, and to determine whether elevated endogenous ADMA is implicated in endothelial dysfunction or...

journal_title：Life sciences

authors： Xiong Y,Lei M,Fu S,Fu Y

更新日期：2005-05-27 00:00:00

abstract：:The effects of isolation and water scheduling on mitogen induced lymphocyte proliferation were investigated. Isolated rats were animals which had been raised in group-housed conditions and then transferred to individual cages with ad lib access to water for a 1 or 2 week period. Water scheduled rats were maintained in...

journal_title：Life sciences

authors： Jessop JJ,Gale K,Bayer BM

更新日期：1988-01-01 00:00:00

abstract：:We have proposed that the atypical opioid system in the mouse may be representative of that in the anorexia nervosa patient and may account for a biological predisposition to the disorder. This is in the context of our auto-addiction model of anorexia nervosa in which endogenous opioids play a critical role in its eti...

journal_title：Life sciences

authors： Marrazzi MA,Mullings-Britton J,Stack L,Powers RJ,Lawhorn J,Graham V,Eccles T,Gunter S

更新日期：1990-01-01 00:00:00

abstract：:Resveratrol, a polyphenolic phytoaxelin present in red wine, has been suggested to protect against atherosclerosis and cardiovascular disease because of its antioxidant effects. Intercellular adhesion molecule (ICAM-1), induced by cytokines, has been hypothesized to play a role in the early events during atheroscleros...

journal_title：Life sciences

authors： Wung BS,Hsu MC,Wu CC,Hsieh CW

更新日期：2005-12-12 00:00:00

abstract：AIMS:This study aims to explore factors that influence glucocorticoid (GC)-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction (IUGR) filial rats. MAIN METHODS:An IUGR animal model was established by starvation, and brain tissue was removed after birth. Affymetrix Rat Gene 2.0 S...

journal_title：Life sciences

authors： Ding YX,Shi Y,Han WJ,Cui H

更新日期：2016-04-01 00:00:00

abstract：:We have investigated the possible involvement of arachidonic acid metabolites in dopamine-induced inhibition of adrenocortical steroidogenesis. Administration of dopamine (5 x 10(-5) M) for 20 min to perifused frog adrenal slices caused a marked reduction of the release of both prostaglandin E2 (PGE2) and 6-keto-PGF1 ...

journal_title：Life sciences

authors： Morra M,Leboulenger F,Homo-Delarche F,Netchitalo P,Vaudry H

更新日期：1989-01-01 00:00:00

abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

journal_title：Life sciences

authors： Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

更新日期：2021-02-01 00:00:00

abstract：:Involvement of a central histaminergic mechanism in the stimulating effect of beta-endorphin (beta-End) on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, was investigated in conscious rats. The rise in serum corticosterone levels, induced by beta-End injected intraventricu...

journal_title：Life sciences

authors： Turoń M,Tytoń J,Bugajski J

更新日期：1991-01-01 00:00:00

abstract：AIMS:Diabetes increases oxidant stress and impairs endothelium-dependent relaxation. We investigated whether the antioxidant 3',4'-dihydroxyflavonol (DiOHF) reduces the release of superoxide (O(2)(-)) and preserves endothelial function in aortae from diabetic rats. MAIN METHODS:Type-1 diabetes was induced in Sprague-D...

journal_title：Life sciences

authors： Woodman OL,Malakul W

更新日期：2009-07-03 00:00:00

abstract：:The acute natriuretic response to atrial peptides (AP) is highly variable in anesthetized rats, and some rats are unresponsive. To determine if this response to AP was affected by dehydration, we measured hematocrit, plasma volume, and natriuresis (delta UNaV) after intravenous injection of 3 micrograms/kg of rat atri...

journal_title：Life sciences

authors： Cole FE,Graci KA,Trippodo NC,MacPhee AA,Pegram BL,Frohlich ED

更新日期：1986-06-02 00:00:00

abstract：:We investigated the mechanism by which glucose refeeding can reverse the enhancement of glycolysis caused by glucose starvation. Human fibroblasts were deprived of glucose for 18 hr and then refed for 1 hr with either (a) medium from sister glucose-starved cultures (controls), (b) fresh, glucose-containing medium (fre...

journal_title：Life sciences

authors： Sorger T,Oliveira M,Germinario RJ

更新日期：1989-01-01 00:00:00

abstract：:Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the presen...

journal_title：Life sciences

authors： Jarho P,Urtti A,Järvinen K,Pate DW,Järvinen T

更新日期：1996-01-01 00:00:00

abstract：:Behavioral study of pro-opiomelanocortin products indicates that beta-endorphin and corticotrophin-like peptides have antagonistic effects. However, these peptides have similar actions on the rat vas deferens. beta-endorphin, alpha-MSH and ACTH each inhibit electrically evoked contraction of the duct, but the corticot...

journal_title：Life sciences

authors： Smock T

更新日期：1986-11-03 00:00:00

abstract：:NF-kappaB that plays an important role in iNOS expression is one of the targets of various potential anti-inflammatory agents including resveratrol. Resveratrol contains a structural similarity with estrogen, and there has been speculation about resveratrol as estrogen agonist. In this study, the mechanism and structu...

journal_title：Life sciences

authors： Cho DI,Koo NY,Chung WJ,Kim TS,Ryu SY,Im SY,Kim KM

更新日期：2002-09-13 00:00:00

abstract：:Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats. ...

journal_title：Life sciences

authors： Bolander HG,Kourtopoulos H

更新日期：1985-03-11 00:00:00

abstract：:Kappa (kappa) opioid agonists induce a water diuresis and inhibit vasopressin (AVP) secretion. Hypothalamic and neurohypophysial sites have both been implicated in the response. The present study was designed to ascertain if kappa-agonist inhibition of osmotically-stimulated AVP secretion is associated with parallel c...

journal_title：Life sciences

authors： Rossi NF,Kim JK,Summers SN,Schrier RW

更新日期：1997-01-01 00:00:00

abstract：:The objective of this study was to investigate whether age induces changes on vasodilator response induced by cromakalim, an ATP-sensitive K+ (K(ATP)) channel opener, as well as the underlying mechanism involved in this possible alteration. For this purpose, aortic segments from young (3-5 months) and old (3 years) ra...

journal_title：Life sciences

authors： Ferrer M,Tejera N,Marín J,Balfagón G

更新日期：1998-01-01 00:00:00

abstract：AIM:Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidati...

journal_title：Life sciences

authors： Aja PM,Izekwe FI,Famurewa AC,Ekpono EU,Nwite FE,Igwenyi IO,Awoke JN,Ani OG,Aloke C,Obasi NA,Udeh KU,Ale BA

更新日期：2020-10-15 00:00:00

abstract：:This paper describes the use of complex liposomes as real membrane models to evaluate the potential benefits of several antioxidants in relation to lipid peroxidation. The xanthine oxidase/Fe(3+)-ADP-EDTA and the Fe(2+)/H2O2 systems have been used to generate hydroxyl radicals and the water soluble azo-compound 2,2'-a...

journal_title：Life sciences

authors： Gutiérrez ME,García AF,Africa de Madariaga M,Sagrista ML,Casadó FJ,Mora M

更新日期：2003-04-11 00:00:00

abstract：:We developed an experimental model to study the effect of daily cocaine administration on the mucosal immune system during murine acquired immune deficiency syndrome (MAIDS). Mice were infected with LP-BM5 murine leukemia virus, a retrovirus which causes immunosuppression with development of functional murine AIDS. Mi...

journal_title：Life sciences

authors： Lopez MC,Watson RR

更新日期：1994-01-01 00:00:00

abstract：AIMS:Insulin-like growth factor (IGF)-1 is a major mitogenic growth factor for mesangial cells (MCs). Statins slow the progression of chronic kidney disease by affecting inflammatory cell signaling pathways, in addition to improving lipid profile, however, no studies have investigated the effects of fluvastatin on mito...

journal_title：Life sciences

authors： Shibata T,Tamura M,Kabashima N,Serino R,Tokunaga M,Matsumoto M,Miyamoto T,Miyazaki M,Furuno Y,Takeuchi M,Abe H,Okazaki M,Otsuji Y

更新日期：2009-05-22 00:00:00

abstract：:The ATP-binding cassette (ABC) and solute carrier (SLC) transporter families consist of common drug transporters that mediate the efflux and uptake of drugs, respectively, and play an important role in the absorption, distribution, metabolism and excretion of drugs in vivo. Rheumatoid arthritis (RA) is an autoimmune d...

journal_title：Life sciences

authors： Gao J,Wang C,Wei W

更新日期：2021-01-08 00:00:00

abstract：:The fructose analogue 2,5-anhydro-D-mannitol (2,5-AM), that inhibits glucose release and ATP formation in liver cells, seems to stimulate feeding by acting on the liver, because hepatic portal injection was more effective than jugular vein injection and because hepatic branch vagotomy attenuated 2,5-AM's hyperphagic e...

journal_title：Life sciences

authors： Lutz TA,Boutellier S,Scharrer E

更新日期：1998-01-01 00:00:00

abstract：AIMS:We sought to reveal the key molecular signature in subcutaneous adipose tissue (scAT) following Roux-en-Y gastric bypass (RYGB), through bioinformatics analysis and further verification in vivo. MAIN METHODS:We obtained a transcriptome data of scAT from RYGB and sham-operated rats from the Gene Expression Omnibus...

journal_title：Life sciences

authors： Chen X,Gong L,Li Q,Hu J,Liu X,Wang Y,Bai J,Ran X,Wu J,Ge Q,Li R,Xiao X,Li X,Zhang J,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:The antioxidative and superoxide- and hydroxyl radical-scavenging activities and pro-oxidant effect of twelve selected medicinal herbs were studied. The aqueous extracts of Coptis chinensis, Paeonia suffruticosa, Prunella vulgaris and Senecio scandens exhibited the highest potency in inhibiting rat erythrocyte hemolys...

journal_title：Life sciences

authors： Liu F,Ng TB

更新日期：2000-01-14 00:00:00