Abstract:
:Behavioral study of pro-opiomelanocortin products indicates that beta-endorphin and corticotrophin-like peptides have antagonistic effects. However, these peptides have similar actions on the rat vas deferens. beta-endorphin, alpha-MSH and ACTH each inhibit electrically evoked contraction of the duct, but the corticotrophin derived peptides are tenfold more potent on a molar basis (ED50 = 9 nM). Pharmacological analysis shows that the action of corticotrophin-derived peptides does not involve an opiate receptor mechanism. The results are discussed in terms of the central action of the peptides.
journal_name
Life Scijournal_title
Life sciencesauthors
Smock Tdoi
10.1016/0024-3205(86)90162-1subject
Has Abstractpub_date
1986-11-03 00:00:00pages
1651-5issue
18eissn
0024-3205issn
1879-0631pii
0024-3205(86)90162-1journal_volume
39pub_type
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