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Membrane immunoglobulin: anti-immunoglobulin interactions mediate the phosphorylation of actin associated proteins in the B-lymphocyte.

Abstract：

:The binding of membrane immunoglobulin (mIg) by anti-Ig antibodies is known to initiate a mitogenic signal in B lymphocytes. Because in many instances growth control appears to be correlated with phosphokinase activity, as well as with alterations in cytoskeletal architecture, we asked the question whether antibodies binding to mIg would also lead to the specific phosphorylation of lymphocyte actin-associated proteins. Utilizing a myosin affinity technique, we directly examined phosphoproteins that were associated with actin in the chicken B cell. We found that in a few instances the level of phosphorylation was indeed modulated by mIg:anti-Ig interactions. These actin-binding phosphoproteins may be important control elements in the lymphocyte cytoskeleton.

journal_name

Life Sci

journal_title

Life sciences

authors

Rosenspire AJ,Choi YS

doi

10.1016/0024-3205(88)90089-6

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

497-504

issue

5

eissn

0024-3205

issn

1879-0631

pii

0024-3205(88)90089-6

journal_volume

42

pub_type

杂志文章

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