当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo.

Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo.

Abstract：

:Cilostazol(6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone) selectively inhibits cGMP-inhibited phosphodiesterase (PDE3) and is a potent inhibitor of platelet aggregation induced by various agonists. Effect of cilostazol on shear stress-induced human platelet aggregation (SIPA) was examined in vitro and ex vivo. Cilostazol inhibited SIPA dose-dependently in vitro. The IC50 value of cilostazol for inhibition of SIPA was 15 +/- 2.6 microM (m +/- SE, n=5), which was very similar to that (12.5 +/- 2.1 microM) for inhibition of ADP-induced platelet aggregation. Cilostazol potentiates the inhibition of SIPA by PGE1 and enhances its ability to increase cAMP concentrations. A single oral adminstration of 100 mg cilostazol to healthy volunteers produced a significant inhibition of SIPA. This study demonstrates that cilostazol is an effective inhibitor of SIPA, which may be important for the prevention and the treatment of arterial occlusive diseases.

journal_name

Life Sci

journal_title

Life sciences

authors

Minami N,Suzuki Y,Yamamoto M,Kihira H,Imai E,Wada H,Kimura Y,Ikeda Y,Shiku H,Nishikawa M

doi

10.1016/s0024-3205(97)00986-7

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

PL 383-9

issue

25

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(97)00986-7

journal_volume

61

pub_type

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