Growth inhibition of capsaicin on HeLa cells is not mediated by intracellular calcium mobilization.

abstract：:The relative potencies of the in vivo vasodilating effect on the arterioles of the hamster cheek pouch of morphine and beta-endorphin decreased significantly after chronic morphine injection, indicating the existence of tolerance to morphine and cross tolerance between morphine and beta-endorphin. The apparent pA2 val...

journal_title：Life sciences

authors： Koo A,Wong TM

更新日期：1983-01-31 00:00:00

abstract：AIMS:Endothelin A receptor (ET(A)R) and epidermal growth factor receptor (EGFR) cross-talk enhances the metastatic potential of epithelial ovarian cancer (EOC) cells activating different pathways, including β-catenin signalling. Here, we evaluated β-catenin as one of ET(A)R/EGFR downstream pathway in the invasive behav...

journal_title：Life sciences

authors： Cianfrocca R,Tocci P,Spinella F,Di Castro V,Bagnato A,Rosanò L

更新日期：2012-10-15 00:00:00

abstract：:In this study, we determined the expression of protein kinase C (PKC) isoforms during pregnancy. At pregnant duration, PKC alpha was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC...

journal_title：Life sciences

authors： Shyu JC,Hsieh YS,Chang CL,Tsai CC,Liu HC,Chang AC,Yang LC,Lin LY,Liu JY

更新日期：1999-01-01 00:00:00

abstract：:Respiring mitochondria represent the major source of superoxide production in most cells, and superoxide anions function as direct precursors of hydrogen peroxide formation within mitochondria. We use a lucigenen-derived chemiluminescence (LDCL) assay to test the hypothesis that intramitochondrial superoxide productio...

journal_title：Life sciences

authors： Capone G,Kim P,Jovanovich S,Payne L,Freund L,Welch K,Miller E,Trush M

更新日期：2002-05-03 00:00:00

abstract：:The infection epidemic event of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was formally declared a pandemic by World Health Organization on March 11th, 2020. Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a new type of coronavirus, which has high contagion and mainly causes respira...

journal_title：Life sciences

authors： Peng W,Wu H,Tan Y,Li M,Yang D,Li S

更新日期：2020-12-01 00:00:00

abstract：AIMS:Asiaticoside (AS) is a saponin monomer extracted from the medicinal plant Centella asiatica, which has a variety of biological effects. We intended to investigate the effects of asiaticoside on a hypoxia-induced pulmonary hypertension (HPH) rat model and examine the possible effects of asiaticoside on TGF-β1/Smad ...

journal_title：Life sciences

authors： Wang XB,Wang W,Zhu XC,Ye WJ,Cai H,Wu PL,Huang XY,Wang LX

更新日期：2015-09-15 00:00:00

abstract：AIMS:Mancozeb is a dithiocarbamate fungicide known to be genotoxic and induces tumors in rodents at various sites. There is no report in the literature about its genotoxicity in humans. Here, we investigated the association between mancozeb exposure and induction of genotoxic and proapoptotic changes in cultured human ...

journal_title：Life sciences

authors： Srivastava AK,Ali W,Singh R,Bhui K,Tyagi S,Al-Khedhairy AA,Srivastava PK,Musarrat J,Shukla Y

更新日期：2012-06-06 00:00:00

abstract：:The role of K+ channels in the relaxations induced by bradykinin, lemakalim, an activator of ATP-sensitive K+ channels and sodium nitroprusside (SNP), a nitric oxide (NO) donor was examined in the isolated mouse trachea precontracted by methacholine (1 microM). 4-aminopyridine (4-AP, 0.1-2 mM), an inhibitor of 4-AP se...

journal_title：Life sciences

authors： Li L,Vaali K,Paakkari I,Vapaatalo H

更新日期：1997-01-01 00:00:00

abstract：:L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol. ...

journal_title：Life sciences

authors： Malec D,Langwiński R

更新日期：1983-01-01 00:00:00

abstract：:It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway. We found that contrary to the earlier reports, two of the phytopathogen...

journal_title：Life sciences

authors： Khan AJ,Minocha SC

更新日期：1989-01-01 00:00:00

abstract：:To investigate whether endogenous opioid peptides mediate time-dependent changes in ventilatory control during prolonged hypoxia, we studied four adult goats at rest during 14 days at simulated high altitude in a hypobaric chamber (PB approximately 450 Torr). Arterial PCO2 fell during the first several hours of hypoxi...

journal_title：Life sciences

authors： Weinberger SE,Steinbrook RA,Carr DB,Fencl V,Gabel RA,Leith DE,Fisher JE,Harris R,Rosenblatt M

更新日期：1987-02-16 00:00:00

abstract：AIMS:The progressive accumulation of beta-amyloid peptide (Abeta), in the form of senile plaques, has been recognized as one of the major causes of Alzheimer's disease (AD) pathology. Increased production of Abeta and the aggregation of Abeta to oligomers have been reported to trigger neurotoxicity, oxidative damage an...

journal_title：Life sciences

authors： Sul D,Kim HS,Lee D,Joo SS,Hwang KW,Park SY

更新日期：2009-02-27 00:00:00

abstract：:The regulation of the production of platelet-derived growth factor (PDGF) and the influence of high glucose concentration, eicosapentaenoic acid (EPA) were studied in cultured human umbilical vein endothelial cells (HUE). The PDGF production of HUE increased markedly depending on glucose concentration. However, EPA (3...

journal_title：Life sciences

authors： Mizutani M,Okuda Y,Suzuki S,Sawada T,Soma M,Yamashita K

更新日期：1995-01-01 00:00:00

abstract：AIM:Investigation whether androgen/androgen receptor (AR) might regulate megalin expression and/or functionality and thus affecting Gentamicin-induced nephrotoxicity (GIN). MAIN METHODS:Male Wistar rats were treated with gentamicin with/out AR ligands (testosterone as agonist and flutamide as antagonist). Megalin expr...

journal_title：Life sciences

authors： Elsakka EGE,Elsisi AM,Mansour OAA,Elsadek BEM,Abd Elaziz AI,Salama SA,Allam S

更新日期：2020-06-15 00:00:00

abstract：UNLABELLED:Isolation of meiotic arrested oocytes from mammalian ovaries involves a resumption of the meiosis. Studying the effect of FSH on this process it was found that doses up to of 0.1 IU/ml did not maintain the meiotic arrest in hamster oocytes in pre-antral follicles during static incubation conditions. However,...

journal_title：Life sciences

authors： Goverde HJ,van de Venne WP

更新日期：1994-01-01 00:00:00

abstract：:Nitric oxide is involved in a countless number of physiological processes and is known to have cytoprotective as well as cytotoxic effects. Increased knowledge about the multifaceted role of nitric oxide in a variety of disease states has led to the design of multiple treatment strategies involving the nitric oxide sy...

journal_title：Life sciences

authors： Grant MK,El-Fakahany EE

更新日期：2004-02-20 00:00:00

abstract：AIMS:β-Adrenoceptors (β-ADRs) mediating the relaxation of rat superior mesenteric arteries (SMAs) were pharmacologically identified, and the effects of chemical sympathetic denervation on β-ADR-mediated relaxation were examined. MAIN METHODS:The tension changes of endothelium-denuded SMAs were isometrically recorded a...

journal_title：Life sciences

authors： Obara K,Shigematsu M,Takahasi H,Iiboshi Y,Yoshioka K,Kasuya Y,Tanaka Y

更新日期：2020-01-15 00:00:00

abstract：:Involvement of cyclic AMP-dependent protein kinase in the desensitization of GABAB receptor expressed in Xenopus oocytes was studied. GABA produced an outward current in the presence of bicuculline, under voltage-clamp conditions. Baclofen mimicked the effect of GABA, thereby indicating that the response to GABA in th...

journal_title：Life sciences

authors： Yoshimura M,Yoshida S,Taniyama K

更新日期：1995-11-17 00:00:00

abstract：:In this study, we evaluated whether butein can inhibit the effects of tumor necrosis factor alpha (TNF-alpha), an inflammatory mediator, in intestinal epithelial HT-29 cells. Butein significantly inhibited TNF-alpha-induced interleukin 8 (IL-8) secretion and mRNA expression. Moreover, butein suppressed the expression ...

journal_title：Life sciences

authors： Lee SH,Seo GS,Jin XY,Ko G,Sohn DH

更新日期：2007-11-10 00:00:00

abstract：:Central administration of neurotensin (NT) results in a variety of neurobehavioral effects which, depending upon the administration site, resemble the effects of antipsychotic drugs (APDs) and psychostimulants. All clinically effective APDs exhibit significant affinities for dopamine D(2) receptors, supporting the hyp...

journal_title：Life sciences

authors： Dobner PR,Deutch AY,Fadel J

更新日期：2003-06-27 00:00:00

abstract：AIM:Pancreatic stellate cells (PSCs) are the main functional cells leading to pancreatic fibrosis. Nicotine is widely considered as an independent risk factor of pancreatic fibrosis, but the mechanism is still unclear. Our study was aimed to explore the effects of nicotine on human pancreatic stellate cells (hPSCs) and...

journal_title：Life sciences

authors： Li Z,Zhang X,Jin T,Hao J

更新日期：2020-02-15 00:00:00

abstract：:The existence of a new factor (AF) in mice acting synergistically with known proaggregatory stimuli has been suggested by the present study in the plasma of mice challenged with intravenous collagen and adrenaline. Indomethacin, nordihydroguaretic acid (NDGA), BW 755C, phentolamine, cimetidine and ketanserin could not...

journal_title：Life sciences

authors： Dikshit M,Srimal RC

更新日期：1990-01-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) is a major pathogen for acute and chronic viral myocarditis. The aim of this study was to investigate the antiviral effects of sophoridine, an alkaloid extracted from Chinese medicinal herb, Sophora flavescens, against CVB3, and the underlying pharmacokinetics. First, we determined the antivir...

journal_title：Life sciences

authors： Zhang Y,Zhu H,Ye G,Huang C,Yang Y,Chen R,Yu Y,Cui X

更新日期：2006-03-20 00:00:00

abstract：:The pressor effect of hemoglobin-based blood substitutes is due partly to their capacity to scavenge nitric oxide (NO), a potent vasodilator. NO also appears to modulate the release of norepinephrine (NE) from sympathetic nerve endings in some blood vessels. Thus studies were designed to determine if contraction occur...

journal_title：Life sciences

authors： Hunter LW,Tyce GM,Rorie DK

更新日期：1996-01-01 00:00:00

abstract：:alpha-Difluoromethylornithine (DFMO) directly infused into a brain-lateral ventricle (12.5, 25 and 50 micrograms/rat) dose- and time-dependently inhibited brain ODC activity. While having no influence per se on pain threshold, DFMO significantly inhibited the analgesic activity of morphine (15 mg/kg i.p.), this effect...

journal_title：Life sciences

authors： Genedani S,Bernardi M,Tagliavini S,Bertolini A

更新日期：1989-01-01 00:00:00

abstract：:Substrate stiffness is essential for cell functions, but the mechanisms by which cell sense mechanical cues are still unclear. Here we show that the frequency and the amplitude of spontaneous Ca2+ oscillations were greater in chick cardiomyocytes cultured on the stiff substrates than that on the soft substrates. The s...

journal_title：Life sciences

authors： Liu S,Gao X,Wu X,Yu Y,Yu Z,Zhao S,Zhao H

更新日期：2019-10-15 00:00:00

abstract：AIMS:Second-generation antipsychotic drugs (SGAs) have a high risk for serious metabolic side-effects including dyslipidemia. This study aimed to investigate the acute effects of oral olanzapine treatment on the expression of genes for fatty acid and cholesterol biosynthesis in rats. MAIN METHODS:Female Sprague-Dawley...

journal_title：Life sciences

authors： Liu X,Deng C,Cao S,Gong J,Wang BC,Hu CH

更新日期：2015-05-01 00:00:00

abstract：:Doxorubicin (DOX) induced cardiotoxicity is a life-threatening side effect of chemotherapy and decreased cardiac function can present years after treatment. Despite the investigation of a broad range of pharmacologic interventions, to date the only drug shown to reduce DOX-related cardiotoxicity in preclinical studies...

journal_title：Life sciences

authors： Zhen J,Yu H,Ji H,Cai L,Leng J,Keller BB

更新日期：2019-12-15 00:00:00

abstract：:The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltre...

journal_title：Life sciences

authors： Eikelboom R

更新日期：1987-03-16 00:00:00

abstract：AIMS:Ideally, mesenchymal stem cells (MSC) home to and/or remain at the site of damaged myocardium when administered after myocardial infarction. However, MSC may not remain in the heart, but instead relocate to other areas. We investigated quantitatively the distribution of labeled rat MSC, given by two routes after c...

journal_title：Life sciences

authors： Hale SL,Dai W,Dow JS,Kloner RA

更新日期：2008-09-26 00:00:00